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Jihong Wu

Publications and source records attributed to Jihong Wu.

2 recordsLinked to original sources

Geometric quantum drives and topological dynamical responses: hyperbolically-driven quantum systems and beyond

We introduce a geometrical framework to construct a large class of time-dependent quantum systems, in which the position of a classical particle moving autonomously on a smooth connected manifold is used to steer a quantum Hamiltonian over time. This results in quantum drives with structured temporal profiles and properties dependent on the local and global nature of the underlying choice of manifold. We show that our construction recovers the well-known classes of periodically-driven and quasiperiodically-driven quantum systems, but also unveils fundamentally new classes of quantum dynamics: by utilizing a compact 2d hyperbolic Bolza surface and a nonorientable Klein-bottle surface, we demonstrate examples of a hyperbolically-driven quantum system and a nonorientably-driven quantum system respectively. Furthermore, we demonstrate that these driven systems exhibit unusual quantized dynamical responses reflecting their different underlying topologies, under the condition of being fully gapped and in the adiabatic limit, and which have interpretations as quantized crystalline electromagnetic responses in certain exotic effective tight-binding lattice models. We envision geometric quantum driving as a general framework to chart the landscape of time-dependent quantum systems and investigate the universal phase structures they exhibit, as well as a useful tool to enhance the capabilities of modern day quantum simulators.

quant-ph

Numerical evaluation of spray position for improved nasal drug delivery

Topical intra-nasal sprays are amongst the most commonly prescribed therapeutic options for sinonasal diseases in humans. However, inconsistency and ambiguity in instructions show a lack of definitive knowledge on best spray use techniques. In this study, we have identified a new usage strategy for nasal sprays available over-the-counter, that registers an average 8-fold improvement in topical delivery of drugs at diseased sites, when compared to prevalent spray techniques. The protocol involves re-orienting the spray axis to harness inertial motion of particulates and has been developed using computational fluid dynamics simulations of respiratory airflow and droplet transport in medical imaging-based digital models. Simulated dose in representative models is validated through in vitro spray measurements in 3D-printed anatomic replicas using the gamma scintigraphy technique. This work breaks new ground in proposing an alternative user-friendly strategy that can significantly enhance topical delivery inside human nose. While these findings can eventually translate into personalized spray usage instructions and hence merit a change in nasal standard-of-care, this study also demonstrates how relatively simple engineering analysis tools can revolutionize everyday healthcare.

physics.med-ph