arXiv subjects

Jinglai Duan

Publications and source records attributed to Jinglai Duan.

3 recordsLinked to original sources

arXiv2026

SERS study of single-live-cell electrical permeabilization dynamics via plasmonic nanotubes

There is a growing demand for minimally invasive methods to analyze intracellular processes and signaling activities in individual living cells, including the identification of tumorigenic cell subpopulations. However, most conventional analytical methods require cell lysis, precluding repeated measurements in the same cell over time, or rely on exogenous labels and reporters that may perturb cellular function. Various applications based on vertical nanotubes have been developed that enable live cell monitoring and analysis by electroporation with low voltages. However, the extent and duration of membrane permeability and kinetics of membrane repair remain elusive. Here, we built a plasmonic platform with the capacity of surface enhanced Raman spectroscopy (SERS) to monitor the electroporation-induced membrane permeability dynamics in individual live cells attached onto 100-nm diameter nanotubes of 2 um height. Fibronectin was employed as extracellular matrix (ECM)-coating to facilitate cell attachment onto nanotubes. Using fluorescent-dye delivery as an independent validation method, we show that the fabricated nanostructures induce localized electrical permeabilization of the plasma membrane and enable monitoring of its subsequent recovery. We further use SERS to track molecular changes at the membrane during permeabilization and resealing. The SERS spectra provide molecular-level insight into changes in membrane-associated components and the ECM during electroporation and subsequent membrane recovery. Real time monitoring of pulse induced molecular changes holds great promise for characterizing intracellular signaling, cellular states, and cellular heterogeneity at the single cell level, including the identification of tumorigenic subpopulations. This capacity could facilitate the development of novel biosensing assay.

physics.app-ph↗

arXiv2026

A Neuroevolution Potential for Gallium Oxide: Accurate and Efficient Modeling of Polymorphism and Swift Heavy-Ion Irradiation

Gallium oxide (Ga2O3) is a wide-bandgap semiconductor with promising applications in high-power and high-frequency electronics. However, its complex polymorphic nature poses substantial challenges for fundamental studies, particularly in understanding phase-transformation behaviors under nonequilibrium conditions. Here, we develop a robust, accurate, and computationally efficient machine-learning interatomic potential (MLIP) for Ga2O3 based on the neuroevolution potential (NEP) framework combined with an energy-dependent weighting strategy. The resulting NEP potential demonstrates clear advantages over the state-of-the-art tabGAP potential with respect to both accuracy and computational efficiency. Furthermore, we introduce a physically process-oriented sampling strategy to systematically augment the training dataset, thereby enhancing the MLIP performance for targeted physical phenomena. As a representative application, a dedicated NEP potential is constructed for swift heavy-ion (SHI) irradiation simulations of \b{eta}-Ga2O3. The simulated results are in quantitative agreement with experimental observations and provide a consistent physical explanation for the reported experimental discrepancies regarding phase transformations in the ion track of \b{eta}-Ga2O3.

cond-mat.mtrl-sci↗

arXiv2017

The Plastic Scintillator Detector at DAMPE

he DArk Matter Particle Explorer (DAMPE) is a general purposed satellite-borne high energy $γ-$ray and cosmic ray detector, and among the scientific objectives of DAMPE are the searches for the origin of cosmic rays and an understanding of Dark Matter particles. As one of the four detectors in DAMPE, the Plastic Scintillator Detector (PSD) plays an important role in the particle charge measurement and the photons/electrons separation. The PSD has 82 modules, each consists of a long organic plastic scintillator bar and two PMTs at both ends for readout, in two layers and covers an overall active area larger than 82 cm $\times$ 82 cm. It can identify the charge states for relativistic ions from H to Fe, and the detector efficiency for Z=1 particles can reach 0.9999. The PSD has been successfully launched with DAMPE on Dec. 17, 2015. In this paper, the design, the assembly, the qualification tests of the PSD and some of the performance measured on the ground have been described in detail.

astro-ph.IM↗