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Jocelyn Xu

Publications and source records attributed to Jocelyn Xu.

3 recordsLinked to original sources

Singer-Informed Vocal Source Separation for Multi-Singer Music Mixtures

Music source separation systems typically extract a single vocal track and do not distinguish between multiple singers. We study singer-informed vocal source separation for multi-singer mixtures. Our framework introduces a short enrollment recording of a target singer to guide separation through a learned embedding. The singer embedding is incorporated using feature concatenation or feature-wise linear modulation (FiLM), enabling the model to focus on the target singer while suppressing interference. We construct a duet dataset based on DAMP-VSEP with quality filtering and non-overlapping enrollment segments. Experiments on solo and duet settings show that while baseline models perform well for single-singer mixtures, the proposed method improves target-singer extraction in multi-singer cases, increasing target-singer SI-SDR from 0.33 dB to 5.58 dB. Fréchet Audio Distance (FAD) further shows improved perceptual quality and better alignment with target audio distributions. Code and checkpoints are available at https://github.com/jocelynxu01/singer-separation-paper.

eess.AS

That's Deprecated! Understanding, Detecting, and Steering Knowledge Conflicts in Language Models for Code Generation

This paper investigates how large language models (LLMs) behave when faced with discrepancies between their parametric knowledge and conflicting information contained in a prompt. Building on prior question-answering (QA) research, we extend the investigation of knowledge conflicts to the realm of code generation. We propose a domain-agnostic framework for constructing and interpreting such conflicts, along with a novel evaluation method and dataset tailored to code conflict scenarios. Our experiments indicate that sufficiently large LLMs encode the notion of a knowledge conflict in their parameters, enabling us to detect knowledge conflicts with up to \textbf{80.65\%} accuracy. Building on these insights, we show that activation-level steering can achieve up to a \textbf{12.6\%} improvement in steering success over a random baseline. However, effectiveness depends critically on balancing model size, task domain, and steering direction. The experiment code and data will be made publicly available after acceptance.

cs.CL

D-CryptO: Deep learning-based analysis of colon organoid morphology from brightfield images

Stem cell-derived organoids are a promising tool to model native human tissues as they resemble human organs functionally and structurally compared to traditional monolayer cell-based assays. For instance, colon organoids can spontaneously develop crypt-like structures similar to those found in the native colon. While analyzing the structural development of organoids can be a valuable readout, using traditional image analysis tools makes it challenging because of the heterogeneities and the abstract nature of organoid morphologies. To address this limitation, we developed and validated a deep learning-based image analysis tool, named D-CryptO, for the classification of organoid morphology. D-CryptO can automatically assess the crypt formation and opacity of colorectal organoids from brightfield images to determine the extent of organoid structural maturity. To validate this tool, changes in organoid morphology were analyzed during organoid passaging and short-term forskolin stimulation. To further demonstrate the potential of D-CryptO for drug testing, organoid structures were analyzed following treatments with a panel of chemotherapeutic drugs. With D-CryptO, subtle variations in how colon organoids responded to the different chemotherapeutic drugs were detected, which suggest potentially distinct mechanisms of action. This tool could be expanded to other organoid types, like intestinal organoids, to facilitate 3D tissue morphological analysis.

q-bio.QM