arXiv subjects

Johan T. Padding

Publications and source records attributed to Johan T. Padding.

6 recordsLinked to original sources

arXiv2026

Trans-stenotic pressure drop estimation from PC-MRI and ultrasound imaging velocimetry using a modified Bernoulli equation

Accurate non-invasive estimation of trans-stenotic pressure gradients remains a challenge. In clinical practice, pressure gradients are often estimated from velocity measurements using Bernoulli-based formulas, but these simplified relations do not explicitly account for how pressure losses change with the flow regime. Here, we introduce a modified Bernoulli (MB) formulation that incorporates regime-dependent pressure losses through a Reynolds-number-dependent loss coefficient. Steady in-vitro experiments were performed in an idealized stenosis model over physiologically relevant flow rates (0.65-3.9 L/min), combining direct pressure measurements with ultrasound imaging velocimetry and phase-contrast magnetic resonance imaging (PC-MRI) to measure velocities. The MB model was calibrated from the measured pressure drops and then evaluated against the simplified Bernoulli (SB) and extended Bernoulli (EB) formulations. Over the tested flow regime, MB agreed best with the measurements. SB and EB showed larger biases, with errors of roughly 10-55% (SB) and -15 to 25% (EB), and overestimated the pressure drop in the clinically relevant range. We additionally quantified the effect of PC-MRI in-plane pixel size on MRI-based pressure estimates. Coarse sampling of the stenosis throat led to systematic underestimation of flow rate and bulk velocity and, consequently, of the MB-predicted pressure drop. In contrast, the peak throat velocity was substantially less sensitive to pixel size, resulting in smaller estimation errors when used as input for the MB. Overall, the results demonstrate that accounting for flow-regime-dependent loss mechanisms enhances pressure drop estimation, and that sufficient sampling of the stenotic throat is crucial for MRI-based flow rate and pressure drop estimation. In addition, peak-velocity-based MB pressure drop estimations are less sensitive to pixel size.

physics.flu-dyn↗

arXiv2024

Unified Framework for Laser-induced Transient Bubble Dynamics within Microchannels

Oscillatory flow in confined spaces is central to understanding physiological flows and rational design of synthetic periodic-actuation based micromachines. Using theory and experiments on oscillating flows generated through a laser-induced cavitation bubble, we associate the dynamic bubble size (fluid velocity) and bubble lifetime to the laser energy supplied - a control parameter in experiments. Employing different channel cross-section shapes, sizes and lengths, we demonstrate the characteristic scales for velocity, time and energy to depend solely on the channel geometry. Contrary to the generally assumed absence of instability in low Reynolds number flows (<1000), we report a momentary flow distortion that originates due to the boundary layer separation near channel walls during flow deceleration. The emergence of distorted laminar states is characterized using two stages. First the conditions for the onset of instabilities is analyzed using the Reynolds number and Womersley number for oscillating flows. Second the growth and the ability of an instability to prevail is analyzed using the convective time scale of the flow. Our findings inform rational design of microsystems leveraging pulsatile flows via cavitation-powered microactuation.

physics.flu-dyn↗

arXiv2023

Laser-Induced Cavitation for Controlling Crystallization from Solution

We demonstrate that a cavitation bubble initiated by a Nd:YAG laser pulse below breakdown threshold induces crystallization from supersaturated aqueous solutions with supersaturation and laser-energy dependent nucleation kinetics. Combining high-speed video microscopy and simulations, we argue that a competition between the dissipation of absorbed laser energy as latent and sensible heat dictates the solvent evaporation rate and creates a momentary supersaturation peak at the vapor-liquid interface. The number and morphology of crystals correlate to the characteristics of the simulated supersaturation peak.

physics.chem-ph↗

arXiv2023

Low-cost fluorescence microscope with microfluidic device fabrication for optofluidic applications

Optofluidic devices have revolutionized the manipulation and transportation of fluid at smaller length scales ranging from micrometers to millimeters. We describe a dedicated optical setup for studying laser-induced cavitation inside a microchannel. In a typical experiment, we use a tightly focused laser beam to locally evaporate the solution laced with a dye resulting in the formation of a microbubble. The evolving bubble interface is tracked using high-speed microscopy and digital image analysis. Furthermore, we extend this system to analyze fluid flow through fluorescence$-$Particle Image Velocimetry (PIV) technique with minimal adaptations. In addition, we demonstrate the protocols for the in-house fabrication of a microchannel tailored to function as a sample holder in this optical setup. In essence, we present a complete guide for constructing a fluorescence microscope from scratch using standard optical components with flexibility in the design and at a lower cost compared to its commercial analogues.

physics.ins-det↗

arXiv2023

A review on laser-induced crystallization from solution

Crystallization is abound in nature and industrial practice. A plethora of indispensable products ranging from agrochemicals and pharmaceuticals to battery materials, are produced in crystalline form in industrial practice. Yet, our control over the crystallization process across scales, from molecular to macroscopic, is far from complete. This bottleneck not only hinders our ability to engineer the properties of crystalline products essential for maintaining our quality of life but also hampers progress toward a sustainable circular economy in resource recovery. In recent years, approaches leveraging light fields have emerged as promising alternatives to manipulate crystallization. In this review article, we classify laser-induced crystallization approaches where light-material interactions are utilized to influence crystallization phenomena according to proposed underlying mechanisms and experimental setups. We discuss non-photochemical laser-induced nucleation, high-intensity laser-induced nucleation, laser trapping-induced crystallization, and indirect methods in detail. Throughout the review, we highlight connections amongst these separately evolving sub-fields to encourage interdisciplinary exchange of ideas.

physics.chem-ph↗

arXiv2019

Hydrodynamic forces on assemblies of non-spherical particles: orientation and voidage effects

This work provides a recipe for creating drag, lift and torque closures for static assemblies of axisymmetric, non-spherical particles. Apart from Reynolds number $Re$ and solids volume fraction $\epsilon_s$, we propose four additional parameters to characterize the flow through non-spherical particle assemblies. Two parameters consider the mutual orientations of particles (the orientation tensor eigenvalues $S_1$ and $S_2$) and two angles represent the flow direction (polar and azimuthal angles $\alpha$ and $\beta$). Interestingly, we observe that the hydrodynamic forces on the particles are independent of the mutual particle orientations. Rather, the most important parameter representing the particle configuration itself is the incident angle $\phi$ of the individual particles with respect to the incoming flow. Moreover, we observe that our earlier finding of sine-squared scaling of drag for isolated particles (Sanjeevi & Padding 2017) holds on average even for a multiparticle system in both the viscous and inertial regimes. Similarly, we observe that the average lift for a multiparticle system follows sine-cosine scaling, as is observed for isolated particles. Such findings are very helpful since the pressure drop of a packed bed or porous media can be computed just with the knowledge of orientation distribution of particles and their drag at $\phi=0^\circ$ and $\phi=90^\circ$ for a given $Re$ and $\epsilon_s$. With the identified dependent parameters, we propose drag, lift and torque closures for multiparticle systems.

physics.flu-dyn↗