arXiv subjects

John A. White

Publications and source records attributed to John A. White.

3 recordsLinked to original sources

arXiv2020

Non-genetic acoustic stimulation of single neurons by a tapered fiber optoacoustic emitter

As an emerging technology, transcranial focused ultrasound has been demonstrated to successfully evoke motor responses in mice, rabbits, and sensory/motor responses in humans. Yet, the spatial resolution of ultrasound does not allow for high-precision stimulation. Here, we developed a tapered fiber optoacoustic emitter (TFOE) for optoacoustic stimulation of neurons with an unprecedented spatial resolution of 20 microns, enabling selective activation of single neurons or subcellular structures, such as axons and dendrites. A single acoustic pulse of 1 microsecond converted by the TFOE from a single laser pulse of 3 nanoseconds is shown as the shortest acoustic stimuli so far for successful neuron activation. The highly localized ultrasound generated by the TFOE made it possible to integrate the optoacoustic stimulation and highly stable patch clamp recording on single neurons. Direct measurements of electrical response of single neurons to acoustic stimulation, which is difficult for conventional ultrasound stimulation, have been demonstrated for the first time. By coupling TFOE with ex vivo brain slice electrophysiology, we unveil cell-type-specific response of excitatory and inhibitory neurons to acoustic stimulation. These results demonstrate that TFOE is a non-genetic single-cell and sub-cellular modulation technology, which could shed new insights into the mechanism of neurostimulation.

q-bio.NC↗

arXiv2013

Corporate Evidential Decision Making in Performance Prediction Domains

Performance prediction or forecasting sporting outcomes involves a great deal of insight into the particular area one is dealing with, and a considerable amount of intuition about the factors that bear on such outcomes and performances. The mathematical Theory of Evidence offers representation formalisms which grant experts a high degree of freedom when expressing their subjective beliefs in the context of decision-making situations like performance prediction. Furthermore, this reasoning framework incorporates a powerful mechanism to systematically pool the decisions made by individual subject matter experts. The idea behind such a combination of knowledge is to improve the competence (quality) of the overall decision-making process. This paper reports on a performance prediction experiment carried out during the European Football Championship in 1996. Relying on the knowledge of four predictors, Evidence Theory was used to forecast the final scores of all 31 matches. The results of this empirical study are very encouraging.

cs.AI↗

arXiv1998

Frequency control in synchronized networks of inhibitory neurons

We analyze the control of frequency for a synchronized inhibitory neuronal network. The analysis is done for a reduced membrane model with a biophysically-based synaptic influence. We argue that such a reduced model can quantitatively capture the frequency behavior of a larger class of neuronal models. We show that in different parameter regimes, the network frequency depends in different ways on the intrinsic and synaptic time constants. Only in one portion of the parameter space, called `phasic', is the network period proportional to the synaptic decay time. These results are discussed in connection with previous work of the authors, which showed that for mildly heterogeneous networks, the synchrony breaks down, but coherence is preserved much more for systems in the phasic regime than in the other regimes. These results imply that for mildly heterogeneous networks, the existence of a coherent rhythm implies a linear dependence of the network period on synaptic decay time, and a much weaker dependence on the drive to the cells. We give experimental evidence for this conclusion.

q-bio.NC↗