arXiv subjects

John Kildea

Publications and source records attributed to John Kildea.

3 recordsLinked to original sources

arXiv2025

Development of a defacing algorithm to protect the privacy of head and neck cancer patients in publicly-accessible radiotherapy datasets

Introduction: The rise in public medical imaging datasets has raised concerns about patient reidentification from head CT scans. However, existing defacing algorithms often remove or distort Organs at Risk (OARs) and Planning Target Volumes (PTVs) in head and neck cancer (HNC) patients, and ignore DICOM-RT Structure Set and Dose data. Therefore, we developed and validated a novel automated defacing algorithm that preserves these critical structures while removing identifiable features from HNC CTs and DICOM-RT data. Methods: Eye contours were used as landmarks to automate the removal of CT pixels above the inferior-most eye slice and anterior to the eye midpoint. Pixels within PTVs were retained if they intersected with the removed region. The body contour and dose map were reshaped to reflect the defaced image. We validated our approach on 829 HNC CTs from 622 patients. Privacy protection was evaluated by applying the FaceNet512 facial recognition algorithm before and after defacing on 3D-rendered CT pairs from 70 patients. Research utility was assessed by examining the impact of defacing on autocontouring performance using LimbusAI and analyzing PTV locations relative to the defaced regions. Results: Before defacing, FaceNet512 matched 97% of patients' CTs. After defacing, this rate dropped to 4%. LimbusAI effectively autocontoured organs in the defaced CTs, with perfect Dice scores of 1 for OARs below the defaced region, and excellent scores exceeding 0.95 for OARs on the same slices as the crop. We found that 86% of PTVs were entirely below the cropped region, 9.1% were on the same slice as the crop without overlap, and only 4.9% extended into the cropped area. Conclusions: We developed a novel defacing algorithm that anonymizes HNC CT scans and related DICOM-RT data while preserving essential structures, enabling the sharing of HNC imaging datasets for Big Data and AI.

physics.med-ph↗

arXiv2025

Quantification of head and neck cancer patients' anatomical changes during radiotherapy: prediction of replanning need

Head and neck cancer (HNC) patients who undergo radiotherapy (RT) may experience anatomical changes during treatment, compromising the validity of the initial treatment plan, necessitating replanning. However, replanning disrupts clinical workflows, creating a stressful environment. Currently, no standardized method exists to determine the total amount of anatomical change that necessitates replanning. This project aimed to create metrics to describe anatomical changes HNC patients may experience during RT and develop machine learning (ML) models to predict RT replanning. We included a cohort of 150 HNC patients treated at the McGill University Health Centre. Based on the shape of the RT structures, we created metrics and developed an extraction pipeline, called HNGeoNatomyX, to automatically calculate them. A univariate metric analysis using linear regression was conducted to obtain the rate of change of each metric. We also obtained the relative variation of each metric between the pre-treatment scan and the fraction at which replanning was requested. Fraction-specific ML models (models that incorporated information available up to and including the specific fraction) for fractions 5, 10, and 15 were built using the metrics, clinical data, and feature selection techniques. To estimate models' performance, we used a repeated stratified 5-fold cross-validation resampling technique and the Area Under the Curve (AUC) of the Receiver Operating Characteristic (ROC) curve. The best specific multivariate models for fractions 5, 10, and 15 yielded testing scores of 0.82, 0.70, and 0.79, respectively. Our models early predicted replanning for 76% of the true positives. The created metrics have the potential to characterize and distinguish which patients will necessitate RT replanning. They show promise in guiding clinicians to evaluate RT replanning for HNC patients and streamline workflows.

physics.med-ph↗

arXiv2025

MedHal: An Evaluation Dataset for Medical Hallucination Detection

We present MedHal, a novel large-scale dataset specifically designed to evaluate if models can detect hallucinations in medical texts. Current hallucination detection methods face significant limitations when applied to specialized domains like medicine, where they can have disastrous consequences. Existing medical datasets are either too small, containing only a few hundred samples, or focus on a single task like Question Answering or Natural Language Inference. MedHal addresses these gaps by: (1) incorporating diverse medical text sources and tasks; (2) providing a substantial volume of annotated samples suitable for training medical hallucination detection models; and (3) including explanations for factual inconsistencies to guide model learning. We demonstrate MedHal's utility by training and evaluating a baseline medical hallucination detection model, showing improvements over general-purpose hallucination detection approaches. This resource enables more efficient evaluation of medical text generation systems while reducing reliance on costly expert review, potentially accelerating the development of medical AI research.

cs.CL↗