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John W. Cain

Publications and source records attributed to John W. Cain.

4 recordsLinked to original sources

Cubic tic-tac-toe: A matching-based approach

In the natural generalization of tic-tac-toe to an $n \times n \times n$ board where $n \in \mathbb{N}$, it is known that the first player has a winning strategy if $n \leq 4$ and that either player can force a draw if $n \geq 8$. The question of whether the first player has a winning strategy if $n = 5, 6$ or $7$ has remained open. Here, we prove that the first player does not have a winning strategy if $n = 7$. The proof, which is computer-assisted, exploits the fact that the second player's first four moves can always be chosen such that their remaining moves can be automated via a simple pairing strategy. The process of finding the pairing strategy involves reframing the problem in such a way that the goal is to seek a maximal matching in a bipartite graph that represents the tic-tac-toe board after each player has made four moves. We use the Hopcroft-Karp matching algorithm to find such maximal matchings.

math.CO

Improved Lower Bounds on the Classical Ramsey Numbers R(4,22) and R(4,25)

Circulant graphs have been used to effectively establish lower bounds on many classical Ramsey numbers. Here, we construct circulant graphs of prime order that sharpen the best published lower bounds on two Ramsey numbers. Generalizing previous work in which quadratic and cubic residues were used to construct circulant graphs for the same purpose, we report on the use of quartic and higher-order residues.

math.CO

Rate-dependent propagation of cardiac action potentials in a one-dimensional fiber

Action potential duration (APD) restitution, which relates APD to the preceding diastolic interval (DI), is a useful tool for predicting the onset of abnormal cardiac rhythms. However, it is known that different pacing protocols lead to different APD restitution curves (RCs). This phenomenon, known as APD rate-dependence, is a consequence of memory in the tissue. In addition to APD restitution, conduction velocity restitution also plays an important role in the spatiotemporal dynamics of cardiac tissue. We present new results concerning rate-dependent restitution in the velocity of propagating action potentials in a one-dimensional fiber. Our numerical simulations show that, independent of the amount of memory in the tissue, waveback velocity exhibits pronounced rate-dependence and the wavefront velocity does not. Moreover, the discrepancy between waveback velocity RCs is most significant for small DI. We provide an analytical explanation of these results, using a system of coupled maps to relate the wavefront and waveback velocities. Our calculations show that waveback velocity rate-dependence is due to APD restitution, not memory.

q-bio.QM

An ionically based mapping model with memory for cardiac restitution

Many features of the sequence of action potentials produced by repeated stimulation of a cardiac patch can be modeled by a 1D mapping, but not the full behavior observed in the restitution portrait: in particular, not (i) distinct slopes for dynamic and S1-S2 restitution (rate dependence) and not (ii) long transients in the approach to steady state (accomodation). To address these shortcomings, \emph{ad hoc} 2D mappings, where the second variable is a ``memory'' variable, have been proposed; it seems that these models exhibit some, but not all, of the relevant behavior. In this paper we introduce a new 2D mapping and determine a set of parameters for it that gives a rather accurate description of the full restitution portrait found for one animal. The changes in the mapping, compared to previous models, result from requiring that the mapping can be derived as an asymptotic limit of a simple ionic model. Among other benefits, one can interpret the parameters in the mapping in terms of the ionic model. The ionic model is an extension of a two-current model that adds a third dependent variable, a generalized concentration. The simplicity of the ionic model and the physiological basis for the mapping contribute to the usefulness of these ideas for describing restitution data in a variety of contexts. The fitting procedure is straightforward and can easily be applied to obtain a mathematical model for data from other experiments, including experiments on different species. Uniqueness of the parameter choice is also discussed.

q-bio.QM