Jolanda J. Wentzel | Searcharxiv

arXiv2026

TG-OT: Topology-guided CCTA-IVUS registration via optimal transport matching

Registering coronary CT angiography (CCTA) and intravascular ultrasound (IVUS) enables comprehensive coronary analysis that neither modality can provide alone, yet their fusion remains challenging due to differences in imaging geometry, resolution, and artifact profiles. Existing methods depend on pre-computed lumen or vessel wall segmentations that are unreliable under IVUS acoustic shadowing from calcifications, limiting their clinical applicability. We propose TG-OT, a fully automatic CCTA-IVUS registration framework that eliminates this dependency by integrating trained feature detectors directly into the registration pipeline. Lightweight CNNs are trained to predict calcifications, bifurcations, and lumen radii on the topological $(θ, z)$ cylinder, encouraging topologically coherent detections without requiring explicit segmentation. Registration is formulated as an optimization over centerline warping parameters, driven by an unbalanced Sinkhorn optimal transport loss on the cylindrical geometry that provides spatially informative gradients even for spatially disjoint predictions, complemented by a lumen matching term. Evaluated on $N{=}47$ paired CCTA-IVUS cases in a 5-fold cross-validation setup, TG-OT achieves strong longitudinal ($\overline{\text{Dice}}_\text{ctl}{=}0.99$), rotational ($\overline{S}_c{=}0.96$), and lumen alignment ($\overline{\text{Dice}}_\text{L}{=}0.69$) without manual interaction or prior segmentation, marking a meaningful step toward clinical integration of automatic CCTA-IVUS fusion.

eess.IV↗

arXiv2025

GReAT: leveraging geometric artery data to improve wall shear stress assessment

Leveraging big data for patient care is promising in many medical fields such as cardiovascular health. For example, hemodynamic biomarkers like wall shear stress could be assessed from patient-specific medical images via machine learning algorithms, bypassing the need for time-intensive computational fluid simulation. However, it is extremely challenging to amass large-enough datasets to effectively train such models. We could address this data scarcity by means of self-supervised pre-training and foundations models given large datasets of geometric artery models. In the context of coronary arteries, leveraging learned representations to improve hemodynamic biomarker assessment has not yet been well studied. In this work, we address this gap by investigating whether a large dataset (8449 shapes) consisting of geometric models of 3D blood vessels can benefit wall shear stress assessment in coronary artery models from a small-scale clinical trial (49 patients). We create a self-supervised target for the 3D blood vessels by computing the heat kernel signature, a quantity obtained via Laplacian eigenvectors, which captures the very essence of the shapes. We show how geometric representations learned from this datasets can boost segmentation of coronary arteries into regions of low, mid and high (time-averaged) wall shear stress even when trained on limited data.

cs.CV↗