SearcharxivSearch

arXiv subjects

Jonathan Hartman

Publications and source records attributed to Jonathan Hartman.

2 recordsLinked to original sources

From Theory to Practice: Demonstrators of FAIR Data Spaces Across Different Sectors

The principles of data spaces for sovereign data exchange across trusted organizations have so far mainly been adopted in business-to-business settings, and recently scaled to cloud environments. Meanwhile, research organizations have established distributed research data infrastructures, respecting the principle that data must be FAIR, i.e., findable, accessible, interoperable and reusable. For mutual benefit of these two communities, the FAIR Data Spaces project aims to connect them towards the vision of a common, cloud-based data space for industry and research. Thus, the project establishes a common legal and ethical framework, common technical building blocks, and it demonstrates the orchestration of multiple building blocks in self-contained settings addressing a diverse range of use cases in domains including health, biodiversity, and engineering. This paper gives a summary of all demonstrators, ranging from research data infrastructures scaled to industry-ready cloud environments to work in progress on building bridges between operational business-to-business data spaces and research data infrastructures.

cs.DC

In Search of Newer Targets for IBD: A Systems and a Network Medicine Approach

Introduction: Crohn's disease and ulcerative colitis, both under the umbrella of inflammatory bowel diseases (IBD), involve many distinct molecular processes. The difference in their molecular processes is studied by using the different genes involved in each disease, and it is explored further for drug targeting and drug repurposing. Methods: The initial set of genes was obtained by mining published literature and several curated databases. The identified genes were then subject to Systems and Network analysis to reveal their molecular processes and shed some light on their pathogenesis. Such methodologies have identified newer targets and drugs that can be repurposed. Results: We use a Systems and Network Medicine approach to understand the mechanism of actions of genes involved in IBD. From an initial set of genes mined from literature and curated databases, we used the Multi-Steiner Tree algorithm implemented within the CoVex systems medicine platform to expand each disease module by incorporating candidate genes with significant connections to the disease-related seed genes. Such expanded disease modules will identify a larger set of potential targets and drugs. We used the Closeness Centrality algorithm implemented within CoVex to search for newer targets and repurposable drugs. Through a network medicine approach, we provide a mechanistic view of the diseases and point to newer drugs and targets. Conclusion: We demonstrate that the Systems and Network Medicine approach is a powerful way to understand diseases and understand their mechanisms of action.

q-bio.MN