Jose Ricardo Arteaga Bejarano

arXiv2024

Time Scale Calculus: A New Approach to Multi-Dose Pharmacokinetic Modeling

In this paper, we use Time Scale Calculus (TSC) to formulate and solve pharmacokinetic models exploring multiple dose dynamics. TSC is a mathematical framework that allows the modeling of dynamical systems comprising continuous and discrete processes. This characteristic makes TSC particularly suited for multi-dose pharmacokinetic problems, which inherently feature a blend of continuous processes (such as absorption, metabolization, and elimination) and discrete events (drug intake). We use this toolkit to derive analytical expressions for blood concentration trajectories under various multi-dose regimens across several flagship pharmacokinetic models. We demonstrate that this mathematical framework furnishes an alternative and simplified way to model and retrieve analytical solutions for multi-dose dynamics. For instance, it enables the study of blood concentration responses to arbitrary dose regimens and facilitates the characterization of the long-term behavior of the solutions, such as their steady state.

math.DS↗

arXiv2011

A Relationship between Geometry and Algebra

The three key documents for study geometry are: 1) "The Elements" of Euclid, 2) the lecture by B. Riemann at Göttingen in 1854 entitled "Über die Hypothesen welche der Geometrie zu Grunde liegen" (On the hypotheses which underlie geometry) and 3) the "Erlangen Program", a document written by F. Klein (1872) on his income as professor at the Faculty of Philosophy and the Senate of the Erlangen University. The latter document F. Klein introduces the concept of group as a tool to study geometry. The concept of a group of transformations of space was known at the time. The purpose of this informative paper is to show a relationship between geometry and algebra through an example, the projective plane. Erlangen program until today continues being a guideline of how to study geometry.

math.HO↗