arXiv subjects

Joseph Brunet

Publications and source records attributed to Joseph Brunet.

5 recordsLinked to original sources

arXiv2026

LoRCA: LoRA Cycle Adaptation for Histology to HiP-CT Translation with DINOv3

Hierarchical Phase-Contrast Tomography (HiP-CT) is a synchrotron based X-ray imaging technique that enables non-destructive, volumetric imaging of intact organs with multi-resolutions bridging 20 $\mu m$/voxel for whole organs to near-cellular resolution ($\sim$0.8 $\mu m$/voxel) in local regions. This offers the opportunity to bring volumetric whole-organ context to histology. However, nonlinear registration between H\&E histology and HiP-CT volumes is challenging due to the differences in feature representations of different colour spaces. Synthesis-before-registration methods have shown strong results in histology-to-MRI and histology-to-CT alignment. However, existing approaches either rely on manual anatomical contours or are trained from scratch without semantic constraints, limiting their generalisability to soft tissue organs and novel modalities. We propose LoRCA (LoRA Cycle Adaptation), a cycle consistent style translation framework built on a shared frozen DINOv3 with modality-specific LoRA adapters, learning modality-specific representations that are decoded and adversarially trained. LoRCA enables structure-preserving translation without requiring paired training data. The frozen backbone is intended to be a structural anchor that prevents content drift by preserving pretrained semantic-extraction capability. We evaluate translation quality using Fr\'echet Inception Distance (FID) and structural fidelity via mutual information and Canny edge preservation. LoRCA outperforms CycleGAN in both translation quality and structural consistency. As a preliminary indicator of downstream registration utility, we find that style-translated images yield increased feature correspondences under MatchAnything on manually aligned HiP-CT and histology test pairs, suggesting that LoRCA-style translation is a promising step towards 2D histological sections to 3D HiP-CT volumes registration.

eess.IV↗

arXiv2026

Fast Eikonal Phase Retrieval for High-Throughput Beamlines

We introduce a fast Eikonal Phase Retrieval (EPR) formulation that accelerates eikonal phase retrieval by more than two orders of magnitude while retaining controlled accuracy. The method is derived from a second-order asymptotic expansion in the propagation distance $L$ and complemented by the leading Wentzel--Kramers--Brillouin (WKB) wave-optics correction, yielding an efficient iterative correction scheme preconditioned by FFT-diagonal, energy-dependent inverse operators (Paganin-type filters). To ensure robustness across practical experimental regimes, we combine two complementary solvers: (i) a local $O(L^2)$ closure that is accurate when eikonal shifts remain sub-pixel, and (ii) a non-local formulation for multi-pixel shifts, in which intensity is propagated through an explicit eikonal ray mapping using a mass-conserving bilinear redisribution on the detector grid, and detector residuals are transferred back to the object grid by the corresponding adjoint (transpose), implemented as bilinear interpolation, before applying an approximate FFT-diagonal preconditioner to accelerate convergence. The same framework supports polychromatic data through a compact spectral discretisation, allowing energy-dependent transport and inversion while keeping the iteration GPU/FFT efficient. Overall, this unified approach enables accurate and computationally efficient phase retrieval across propagation conditions relevant to high-throughput PPC-$\mu$CT experiments.

physics.optics↗

arXiv2025

Cardiotensor: A Python Library for Orientation Analysis and Tractography in 3D Cardiac Imaging

Understanding the architecture of the human heart requires analysis of its microstructural organization across scales. With the advent of high-resolution imaging techniques such as synchrotron-based tomography, it has become possible to visualize entire hearts at micron-scale resolution. However, translating these large, complex volumetric datasets into interpretable, quantitative descriptors of cardiac organization remains a major challenge. Here we present cardiotensor, an open-source Python package designed to quantify 3D cardiomyocyte orientation in whole- or partial-heart imaging datasets. It provides efficient, scalable implementations of structure tensor analysis, enabling extraction of directional metrics such as helical angle (HA), intrusion angle (IA), and fractional anisotropy (FA). The package supports datasets reaching teravoxel-scale and is optimized for high-performance computing environments, including parallel and chunk-based processing pipelines. In addition, cardiotensor includes tractography functionality to reconstruct continuous cardiomyocyte trajectories. This enables multi-scale myoaggregate visualization down to the myocyte level, depending on resolution. These capabilities enable detailed structural mapping of cardiac tissue, supporting the assessment of anatomical continuity and regional organization.

cs.CE↗

arXiv2023

Eikonal phase retrieval: Unleashing the fourth generation sources potential for enhanced propagation based tomography on biological samples

The evolution of synchrotrons towards higher brilliance beams has increased the possible sample-to-detector propagation distances for which the source confusion circle does not lead to geometrical blurring. This makes it possible to push near-field propagation driven phase contrast enhancement to the limit, revealing low contrast features which would otherwise remain hidden under an excessive noise. Until today this possibility was hindered, in many objects of scientific interest, by the simultaneous presence of strong phase gradient regions and low contrast features. The strong gradients, when enhanced with the now possible long propagation distances, induce such strong phase effects that the linearisation assumptions of current state-of-the-art single-distance phase retrieval filters are broken, and the resulting image quality is jeopardized. Here, we introduce a new iterative phase-retrieval algorithm and compare it with the Paganin phase-retrieval algorithm, in both the monochromatic and polychromatic cases, obtaining superior image quality. In the polychromatic case the comparison was done with an extrapolated Paganin algorithm obtained by reintroducing, into our phase retrieval algorithm, the linearization approximations underlying the Paganin forward model. Our work provides an innovative algorithm which efficiently performs the phase retrieval task over the entire near-field range, producing images of exceptional quality for mixed attenuation objects.

physics.med-ph↗

arXiv2023

Deep Learning for Vascular Segmentation and Applications in Phase Contrast Tomography Imaging

Automated blood vessel segmentation is vital for biomedical imaging, as vessel changes indicate many pathologies. Still, precise segmentation is difficult due to the complexity of vascular structures, anatomical variations across patients, the scarcity of annotated public datasets, and the quality of images. We present a thorough literature review, highlighting the state of machine learning techniques across diverse organs. Our goal is to provide a foundation on the topic and identify a robust baseline model for application to vascular segmentation in a new imaging modality, Hierarchical Phase Contrast Tomography (HiP CT). Introduced in 2020 at the European Synchrotron Radiation Facility, HiP CT enables 3D imaging of complete organs at an unprecedented resolution of ca. 20mm per voxel, with the capability for localized zooms in selected regions down to 1mm per voxel without sectioning. We have created a training dataset with double annotator validated vascular data from three kidneys imaged with HiP CT in the context of the Human Organ Atlas Project. Finally, utilising the nnU Net model, we conduct experiments to assess the models performance on both familiar and unseen samples, employing vessel specific metrics. Our results show that while segmentations yielded reasonably high scores such as clDice values ranging from 0.82 to 0.88, certain errors persisted. Large vessels that collapsed due to the lack of hydrostatic pressure (HiP CT is an ex vivo technique) were segmented poorly. Moreover, decreased connectivity in finer vessels and higher segmentation errors at vessel boundaries were observed. Such errors obstruct the understanding of the structures by interrupting vascular tree connectivity. Through our review and outputs, we aim to set a benchmark for subsequent model evaluations using various modalities, especially with the HiP CT imaging database.

eess.IV↗