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Joseph Sartini

Publications and source records attributed to Joseph Sartini.

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Bayesian Multivariate Sparse Functional Principal Components Analysis

Functional Principal Components Analysis (FPCA) provides a parsimonious, semi-parametric model for multivariate, sparsely-observed functional data. Frequentist FPCA approaches estimate principal components (PCs) from the data, then condition on these estimates in subsequent analyses. As an alternative, we propose a fully-Bayesian inferential framework for multivariate, sparse functional data (MSFAST) which explicitly models the PCs and incorporates their uncertainty. MSFAST builds upon the FAST approach to FPCA for univariate, densely-observed functional data. Like FAST, MSFAST represents PCs using orthonormal splines and samples the orthonormal spline coefficients using parameter expansion. MSFAST extends FAST to multivariate, sparsely-observed data by (1) standardizing each functional covariate to mitigate poor posterior conditioning due to disparate scales; (2) using a better-suited orthogonal spline basis; (3) updating parameterizations for computational stability; (4) introducing routines that leverage multiple cores and threads to accelerate compute; (5) using a Procrustes-based posterior PC alignment procedure; and (6) providing efficient prediction routines. We evaluate MSFAST alongside existing implementations using simulations. MSFAST produces uniquely valid inferences and accurate estimates, particularly in smaller signal-to-noise regimes. MSFAST is motivated by and applied to a study of child growth, with an accompanying vignette illustrating the implementation step-by-step.

stat.ME

Sufficient conditions for proper posteriors in fully-Bayesian Functional PCA

In a fully-Bayesian Functional Principal Components Analysis (FPCA) the principal components are treated as unknown infinite-dimensional parameters. By projecting the functional principal components on a rich orthonormal spline basis, we show that orthonormality of the principal components is equivalent to orthonormality of the spline coefficients. A penalty on the integral of the second derivative of the functional principal components can be induced on the spline coefficients, where each function has its own smoothing parameter. Finally, each smoothing parameter is treated as an inverse variance component in the associated mixed effects model. In this work, we demonstrate that no additional conditions are required to ensure that the corresponding smoothing prior, and thus the posterior distribution, is proper. This allows the choice of less informative priors, such that smoothing is driven by the data.

stat.ME

Fast Bayesian Functional Principal Components Analysis

Functional Principal Components Analysis (FPCA) is a widely used analytic tool for dimension reduction of functional data. Traditional implementations of FPCA estimate the principal components from the data, then treat these estimates as fixed in subsequent analyses. To account for the uncertainty of PC estimates, we propose FAST, a fully-Bayesian FPCA with three core components: (1) projection of eigenfunctions onto an orthonormal spline basis; (2) efficient sampling of the orthonormal spline coefficient matrix using a parameter expansion scheme based on polar decomposition; and (3) ordering eigenvalues during sampling. Extensive simulation studies show that FAST is very stable and performs better compared to existing methods. FAST is motivated by and applied to a study of the variability in mealtime glucose from the Dietary Approaches to Stop Hypertension for Diabetes Continuous Glucose Monitoring (DASH4D CGM) study. All relevant STAN code and simulation routines are available as supplementary material.

stat.ME

Prediction Inference Using Generalized Functional Mixed Effects Models

We introduce inferential methods for prediction based on functional random effects in generalized functional mixed effects models. This is similar to the inference for random effects in generalized linear mixed effects models (GLMMs), but for functional instead of scalar outcomes. The method combines: (1) local GLMMs to extract initial estimators of the functional random components on the linear predictor scale; (2) structural functional principal components analysis (SFPCA) for dimension reduction; and (3) global Bayesian multilevel model conditional on the eigenfunctions for inference on the functional random effects. Extensive simulations demonstrate excellent coverage properties of credible intervals for the functional random effects in a variety of scenarios and for different data sizes. To our knowledge, this is the first time such simulations are conducted and reported, likely because prediction inference was not viewed as a priority and existing methods are too slow to calculate coverage. Methods are implemented in a reproducible R package and demonstrated using the NHANES 2011-2014 accelerometry data.

stat.ME