arXiv subjects

Joyce Chen

Publications and source records attributed to Joyce Chen.

4 recordsLinked to original sources

arXiv2026

Implementing the principal stratum strategy for intercurrent events with survival outcomes: a tutorial

The International Council for Harmonization (ICH) E9 (R1) addendum provides the estimand framework to formulate treatment effects in a clinical trial. One of the attributes of an estimand the framework describes is intercurrent events. Among the five strategies to intercurrent events the guidance lists, the principal stratum strategy is the most conceptually and technically challenging because it defines treatment effects on unobserved strata. Its application to survival outcomes is particularly inaccessible to practitioners. This tutorial reviews the methodology and implementation of the estimand framework with the principal stratum strategy to address intercurrent events with survival outcomes. We illustrate using a clinical trial in oncology and focus on a simple case with binary treatment and a single binary intercurrent event of discontinuation of the assigned treatment. We define the causal effects and review two main methods for estimating the effects: the mixture model method and the weighting method. For each method, we elaborate the associated assumptions, models, sensitivity analysis, software and provide example R code. We conduct simulation studies that mimic the real study to study the operation characteristics of these methods.

stat.ME↗

arXiv2026

BanditLP: Large-Scale Stochastic Optimization for Personalized Recommendations

We present BanditLP, a scalable multi-stakeholder contextual bandit framework that unifies neural Thompson Sampling for learning objective-specific outcomes with a large-scale linear program for constrained action selection at serving time. The methodology is application-agnostic, compatible with arbitrary neural architectures, and deployable at web scale, with an LP solver capable of handling billions of variables. Experiments on public benchmarks and synthetic data show consistent gains over strong baselines. We apply this approach in LinkedIn's email marketing system and demonstrate business win, illustrating the value of integrated exploration and constrained optimization in production.

cs.LG↗

arXiv2025

Beyond Basic A/B testing: Improving Statistical Efficiency for Business Growth

The standard A/B testing approaches are mostly based on t-test in large scale industry applications. These standard approaches however suffers from low statistical power in business settings, due to nature of small sample-size or non-Gaussian distribution or return-on-investment (ROI) consideration. In this paper, we (i) show the statistical efficiency of using estimating equation and U statistics, which can address these issues separately; and (ii) propose a novel doubly robust generalized U that allows flexible definition of treatment effect, and can handles small samples, distribution robustness, ROI and confounding consideration in one framework. We provide theoretical results on asymptotics and efficiency bounds, together with insights on the efficiency gain from theoretical analysis. We further conduct comprehensive simulation studies, apply the methods to multiple real A/B tests at LinkedIn, and share results and learnings that are broadly useful.

stat.ME↗

arXiv2024

Neural Optimization with Adaptive Heuristics for Intelligent Marketing System

Computational marketing has become increasingly important in today's digital world, facing challenges such as massive heterogeneous data, multi-channel customer journeys, and limited marketing budgets. In this paper, we propose a general framework for marketing AI systems, the Neural Optimization with Adaptive Heuristics (NOAH) framework. NOAH is the first general framework for marketing optimization that considers both to-business (2B) and to-consumer (2C) products, as well as both owned and paid channels. We describe key modules of the NOAH framework, including prediction, optimization, and adaptive heuristics, providing examples for bidding and content optimization. We then detail the successful application of NOAH to LinkedIn's email marketing system, showcasing significant wins over the legacy ranking system. Additionally, we share details and insights that are broadly useful, particularly on: (i) addressing delayed feedback with lifetime value, (ii) performing large-scale linear programming with randomization, (iii) improving retrieval with audience expansion, (iv) reducing signal dilution in targeting tests, and (v) handling zero-inflated heavy-tail metrics in statistical testing.

stat.ME↗