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Juan Gómez-Luna

Publications and source records attributed to Juan Gómez-Luna.

At least 37 records · Page 2Linked to original sources
arXiv2023

SimplePIM: A Software Framework for Productive and Efficient Processing-in-Memory

Data movement between memory and processors is a major bottleneck in modern computing systems. The processing-in-memory (PIM) paradigm aims to alleviate this bottleneck by performing computation inside memory chips. Real PIM hardware (e.g., the UPMEM system) is now available and has demonstrated potential in many applications. However, programming such real PIM hardware remains a challenge for many programmers. This paper presents a new software framework, SimplePIM, to aid programming real PIM systems. The framework processes arrays of arbitrary elements on a PIM device by calling iterator functions from the host and provides primitives for communication among PIM cores and between PIM and the host system. We implement SimplePIM for the UPMEM PIM system and evaluate it on six major applications. Our results show that SimplePIM enables 66.5% to 83.1% reduction in lines of code in PIM programs. The resulting code leads to higher performance (between 10% and 37% speedup) than hand-optimized code in three applications and provides comparable performance in three others. SimplePIM is fully and freely available at https://github.com/CMU-SAFARI/SimplePIM.

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arXiv2023

Extending Memory Capacity in Consumer Devices with Emerging Non-Volatile Memory: An Experimental Study

The number and diversity of consumer devices are growing rapidly, alongside their target applications' memory consumption. Unfortunately, DRAM scalability is becoming a limiting factor to the available memory capacity in consumer devices. As a potential solution, manufacturers have introduced emerging non-volatile memories (NVMs) into the market, which can be used to increase the memory capacity of consumer devices by augmenting or replacing DRAM. Since entirely replacing DRAM with NVM in consumer devices imposes large system integration and design challenges, recent works propose extending the total main memory space available to applications by using NVM as swap space for DRAM. However, no prior work analyzes the implications of enabling a real NVM-based swap space in real consumer devices. In this work, we provide the first analysis of the impact of extending the main memory space of consumer devices using off-the-shelf NVMs. We extensively examine system performance and energy consumption when the NVM device is used as swap space for DRAM main memory to effectively extend the main memory capacity. For our analyses, we equip real web-based Chromebook computers with the Intel Optane SSD, which is a state-of-the-art low-latency NVM-based SSD device. We compare the performance and energy consumption of interactive workloads running on our Chromebook with NVM-based swap space, where the Intel Optane SSD capacity is used as swap space to extend main memory capacity, against two state-of-the-art systems: (i) a baseline system with double the amount of DRAM than the system with the NVM-based swap space; and (ii) a system where the Intel Optane SSD is naively replaced with a state-of-the-art (yet slower) off-the-shelf NAND-flash-based SSD, which we use as a swap space of equivalent size as the NVM-based swap space.

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arXiv2023

Casper: Accelerating Stencil Computation using Near-cache Processing

Stencil computation is one of the most used kernels in a wide variety of scientific applications, ranging from large-scale weather prediction to solving partial differential equations. Stencil computations are characterized by three unique properties: (1) low arithmetic intensity, (2) limited temporal data reuse, and (3) regular and predictable data access pattern. As a result, stencil computations are typically bandwidth-bound workloads, which only experience limited benefits from the deep cache hierarchy of modern CPUs. In this work, we propose Casper, a near-cache accelerator consisting of specialized stencil compute units connected to the last-level cache (LLC) of a traditional CPU. Casper is based on two key ideas: (1) avoiding the cost of moving rarely reused data through the cache hierarchy, and (2) exploiting the regularity of the data accesses and the inherent parallelism of the stencil computation to increase the overall performance. With minimal changes in LLC address decoding logic and data placement, Casper performs stencil computations at the peak bandwidth of the LLC. We show that, by tightly coupling lightweight stencil compute units near to LLC, Casper improves the performance of stencil kernels by 1.65x on average, while reducing the energy consumption by 35% compared to a commercial high-performance multi-core processor. Moreover, Casper provides a 37x improvement in performance-per-area compared to a state-of-the-art GPU.

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arXiv2023

An Experimental Evaluation of Machine Learning Training on a Real Processing-in-Memory System

Training machine learning (ML) algorithms is a computationally intensive process, which is frequently memory-bound due to repeatedly accessing large training datasets. As a result, processor-centric systems (e.g., CPU, GPU) suffer from costly data movement between memory units and processing units, which consumes large amounts of energy and execution cycles. Memory-centric computing systems, i.e., with processing-in-memory (PIM) capabilities, can alleviate this data movement bottleneck. Our goal is to understand the potential of modern general-purpose PIM architectures to accelerate ML training. To do so, we (1) implement several representative classic ML algorithms (namely, linear regression, logistic regression, decision tree, K-Means clustering) on a real-world general-purpose PIM architecture, (2) rigorously evaluate and characterize them in terms of accuracy, performance and scaling, and (3) compare to their counterpart implementations on CPU and GPU. Our evaluation on a real memory-centric computing system with more than 2500 PIM cores shows that general-purpose PIM architectures can greatly accelerate memory-bound ML workloads, when the necessary operations and datatypes are natively supported by PIM hardware. For example, our PIM implementation of decision tree is $27\times$ faster than a state-of-the-art CPU version on an 8-core Intel Xeon, and $1.34\times$ faster than a state-of-the-art GPU version on an NVIDIA A100. Our K-Means clustering on PIM is $2.8\times$ and $3.2\times$ than state-of-the-art CPU and GPU versions, respectively. To our knowledge, our work is the first one to evaluate ML training on a real-world PIM architecture. We conclude with key observations, takeaways, and recommendations that can inspire users of ML workloads, programmers of PIM architectures, and hardware designers & architects of future memory-centric computing systems.

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arXiv2023

TransPimLib: A Library for Efficient Transcendental Functions on Processing-in-Memory Systems

Processing-in-memory (PIM) promises to alleviate the data movement bottleneck in modern computing systems. However, current real-world PIM systems have the inherent disadvantage that their hardware is more constrained than in conventional processors (CPU, GPU), due to the difficulty and cost of building processing elements near or inside the memory. As a result, general-purpose PIM architectures support fairly limited instruction sets and struggle to execute complex operations such as transcendental functions and other hard-to-calculate operations (e.g., square root). These operations are particularly important for some modern workloads, e.g., activation functions in machine learning applications. In order to provide support for transcendental (and other hard-to-calculate) functions in general-purpose PIM systems, we present \emph{TransPimLib}, a library that provides CORDIC-based and LUT-based methods for trigonometric functions, hyperbolic functions, exponentiation, logarithm, square root, etc. We develop an implementation of TransPimLib for the UPMEM PIM architecture and perform a thorough evaluation of TransPimLib's methods in terms of performance and accuracy, using microbenchmarks and three full workloads (Blackscholes, Sigmoid, Softmax). We open-source all our code and datasets at~\url{https://github.com/CMU-SAFARI/transpimlib}.

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arXiv2023

SPARTA: Spatial Acceleration for Efficient and Scalable Horizontal Diffusion Weather Stencil Computation

Fast and accurate climate simulations and weather predictions are critical for understanding and preparing for the impact of climate change. Real-world weather and climate modeling consist of complex compound stencil kernels that do not perform well on conventional architectures. Horizontal diffusion is one such important compound stencil found in many climate and weather prediction models. Recent works propose using FPGAs as an alternative to traditional CPU and GPU-based systems to accelerate compound stencil kernels. However, we observe that compound stencil computations cannot leverage the bit-level flexibility available on an FPGA because of its complex memory access patterns, leading to high hardware resource utilization and low peak performance. We introduce SPARTA, a novel spatial accelerator for horizontal diffusion weather stencil computation. We exploit the two-dimensional spatial architecture to efficiently accelerate horizontal diffusion stencil by designing the first scaled-out spatial accelerator using MLIR (Multi-Level Intermediate Representation) compiler framework. We evaluate its performance on a real cutting-edge AMD-Xilinx Versal AI Engine spatial architecture. Our real-system evaluation results demonstrate that SPARTA outperforms the state-of-the-art CPU, GPU, and FPGA implementations by 17.1x, 1.2x, and 2.1x, respectively. Our results reveal that balancing workload across the available processing resources is crucial in achieving high performance on spatial architectures. We also implement and evaluate five elementary stencils that are commonly used as benchmarks for stencil computation research. We freely open-source all our implementations to aid future research in stencil computation and spatial computing systems at https://github.com/CMU-SAFARI/SPARTA.

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arXiv2023

Scrooge: A Fast and Memory-Frugal Genomic Sequence Aligner for CPUs, GPUs, and ASICs

Pairwise sequence alignment is a very time-consuming step in common bioinformatics pipelines. Speeding up this step requires heuristics, efficient implementations, and/or hardware acceleration. A promising candidate for all of the above is the recently proposed GenASM algorithm. We identify and address three inefficiencies in the GenASM algorithm: it has a high amount of data movement, a large memory footprint, and does some unnecessary work. We propose Scrooge, a fast and memory-frugal genomic sequence aligner. Scrooge includes three novel algorithmic improvements which reduce the data movement, memory footprint, and the number of operations in the GenASM algorithm. We provide efficient open-source implementations of the Scrooge algorithm for CPUs and GPUs, which demonstrate the significant benefits of our algorithmic improvements. For long reads, the CPU version of Scrooge achieves a 20.1x, 1.7x, and 2.1x speedup over KSW2, Edlib, and a CPU implementation of GenASM, respectively. The GPU version of Scrooge achieves a 4.0x 80.4x, 6.8x, 12.6x and 5.9x speedup over the CPU version of Scrooge, KSW2, Edlib, Darwin-GPU, and a GPU implementation of GenASM, respectively. We estimate an ASIC implementation of Scrooge to use 3.6x less chip area and 2.1x less power than a GenASM ASIC while maintaining the same throughput. Further, we systematically analyze the throughput and accuracy behavior of GenASM and Scrooge under various configurations. As the best configuration of Scrooge depends on the computing platform, we make several observations that can help guide future implementations of Scrooge. Availability: https://github.com/CMU-SAFARI/Scrooge

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arXiv2023

DAMOV: A New Methodology and Benchmark Suite for Evaluating Data Movement Bottlenecks

Data movement between the CPU and main memory is a first-order obstacle against improving performance, scalability, and energy efficiency in modern systems. Computer systems employ a range of techniques to reduce overheads tied to data movement, spanning from traditional mechanisms (e.g., deep multi-level cache hierarchies, aggressive hardware prefetchers) to emerging techniques such as Near-Data Processing (NDP), where some computation is moved close to memory. Our goal is to methodically identify potential sources of data movement over a broad set of applications and to comprehensively compare traditional compute-centric data movement mitigation techniques to more memory-centric techniques, thereby developing a rigorous understanding of the best techniques to mitigate each source of data movement. With this goal in mind, we perform the first large-scale characterization of a wide variety of applications, across a wide range of application domains, to identify fundamental program properties that lead to data movement to/from main memory. We develop the first systematic methodology to classify applications based on the sources contributing to data movement bottlenecks. From our large-scale characterization of 77K functions across 345 applications, we select 144 functions to form the first open-source benchmark suite (DAMOV) for main memory data movement studies. We select a diverse range of functions that (1) represent different types of data movement bottlenecks, and (2) come from a wide range of application domains. Using NDP as a case study, we identify new insights about the different data movement bottlenecks and use these insights to determine the most suitable data movement mitigation mechanism for a particular application. We open-source DAMOV and the complete source code for our new characterization methodology at https://github.com/CMU-SAFARI/DAMOV.

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arXiv2023

Morpheus: Extending the Last Level Cache Capacity in GPU Systems Using Idle GPU Core Resources

Graphics Processing Units (GPUs) are widely-used accelerators for data-parallel applications. In many GPU applications, GPU memory bandwidth bottlenecks performance, causing underutilization of GPU cores. Hence, disabling many cores does not affect the performance of memory-bound workloads. While simply power-gating unused GPU cores would save energy, prior works attempt to better utilize GPU cores for other applications (ideally compute-bound), which increases the GPU's total throughput. In this paper, we introduce Morpheus, a new hardware/software co-designed technique to boost the performance of memory-bound applications. The key idea of Morpheus is to exploit unused core resources to extend the GPU last level cache (LLC) capacity. In Morpheus, each GPU core has two execution modes: compute mode and cache mode. Cores in compute mode operate conventionally and run application threads. However, for the cores in cache mode, Morpheus invokes a software helper kernel that uses the cores' on-chip memories (i.e., register file, shared memory, and L1) in a way that extends the LLC capacity for a running memory-bound workload. Morpheus adds a controller to the GPU hardware to forward LLC requests to either the conventional LLC (managed by hardware) or the extended LLC (managed by the helper kernel). Our experimental results show that Morpheus improves the performance and energy efficiency of a baseline GPU architecture by an average of 39% and 58%, respectively, across several memory-bound workloads. Morpheus' performance is within 3% of a GPU design that has a quadruple-sized conventional LLC. Morpheus can thus contribute to reducing the hardware dedicated to a conventional LLC by exploiting idle cores' on-chip memory resources as additional cache capacity.

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arXiv2023

Benchmarking Memory-Centric Computing Systems: Analysis of Real Processing-in-Memory Hardware

Many modern workloads such as neural network inference and graph processing are fundamentally memory-bound. For such workloads, data movement between memory and CPU cores imposes a significant overhead in terms of both latency and energy. A major reason is that this communication happens through a narrow bus with high latency and limited bandwidth, and the low data reuse in memory-bound workloads is insufficient to amortize the cost of memory access. Fundamentally addressing this data movement bottleneck requires a paradigm where the memory system assumes an active role in computing by integrating processing capabilities. This paradigm is known as processing-in-memory (PIM). Recent research explores different forms of PIM architectures, motivated by the emergence of new technologies that integrate memory with a logic layer, where processing elements can be easily placed. Past works evaluate these architectures in simulation or, at best, with simplified hardware prototypes. In contrast, the UPMEM company has designed and manufactured the first publicly-available real-world PIM architecture. The UPMEM PIM architecture combines traditional DRAM memory arrays with general-purpose in-order cores, called DRAM Processing Units (DPUs), integrated in the same chip. This paper presents key takeaways from the first comprehensive analysis of the first publicly-available real-world PIM architecture. We provide four key takeaways about the UPMEM PIM architecture, which stem from our study. More insights about suitability of different workloads to the PIM system, programming recommendations for software designers, and suggestions and hints for hardware and architecture designers of future PIM systems are available in arXiv:2105.03814

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arXiv2023

A Framework for High-throughput Sequence Alignment using Real Processing-in-Memory Systems

Sequence alignment is a memory bound computation whose performance in modern systems is limited by the memory bandwidth bottleneck. Processing-in-memory architectures alleviate this bottleneck by providing the memory with computing competencies. We propose Alignment-in-Memory (AIM), a framework for high-throughput sequence alignment using processing-in-memory, and evaluate it on UPMEM, the first publicly-available general-purpose programmable processing-in-memory system. Our evaluation shows that a real processing-in-memory system can substantially outperform server-grade multi-threaded CPU systems running at full-scale when performing sequence alignment for a variety of algorithms, read lengths, and edit distance thresholds. We hope that our findings inspire more work on creating and accelerating bioinformatics algorithms for such real processing-in-memory systems. Our code is available at https://github.com/safaad/aim.

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arXiv2023

Accelerating Neural Network Inference with Processing-in-DRAM: From the Edge to the Cloud

Neural networks (NNs) are growing in importance and complexity. A neural network's performance (and energy efficiency) can be bound either by computation or memory resources. The processing-in-memory (PIM) paradigm, where computation is placed near or within memory arrays, is a viable solution to accelerate memory-bound NNs. However, PIM architectures vary in form, where different PIM approaches lead to different trade-offs. Our goal is to analyze, discuss, and contrast DRAM-based PIM architectures for NN performance and energy efficiency. To do so, we analyze three state-of-the-art PIM architectures: (1) UPMEM, which integrates processors and DRAM arrays into a single 2D chip; (2) Mensa, a 3D-stack-based PIM architecture tailored for edge devices; and (3) SIMDRAM, which uses the analog principles of DRAM to execute bit-serial operations. Our analysis reveals that PIM greatly benefits memory-bound NNs: (1) UPMEM provides 23x the performance of a high-end GPU when the GPU requires memory oversubscription for a general matrix-vector multiplication kernel; (2) Mensa improves energy efficiency and throughput by 3.0x and 3.1x over the Google Edge TPU for 24 Google edge NN models; and (3) SIMDRAM outperforms a CPU/GPU by 16.7x/1.4x for three binary NNs. We conclude that the ideal PIM architecture for NN models depends on a model's distinct attributes, due to the inherent architectural design choices.

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arXiv2022

LEAPER: Fast and Accurate FPGA-based System Performance Prediction via Transfer Learning

Machine learning has recently gained traction as a way to overcome the slow accelerator generation and implementation process on an FPGA. It can be used to build performance and resource usage models that enable fast early-stage design space exploration. First, training requires large amounts of data (features extracted from design synthesis and implementation tools), which is cost-inefficient because of the time-consuming accelerator design and implementation process. Second, a model trained for a specific environment cannot predict performance or resource usage for a new, unknown environment. In a cloud system, renting a platform for data collection to build an ML model can significantly increase the total-cost-ownership (TCO) of a system. Third, ML-based models trained using a limited number of samples are prone to overfitting. To overcome these limitations, we propose LEAPER, a transfer learning-based approach for prediction of performance and resource usage in FPGA-based systems. The key idea of LEAPER is to transfer an ML-based performance and resource usage model trained for a low-end edge environment to a new, high-end cloud environment to provide fast and accurate predictions for accelerator implementation. Experimental results show that LEAPER (1) provides, on average across six workloads and five FPGAs, 85% accuracy when we use our transferred model for prediction in a cloud environment with 5-shot learning and (2) reduces design-space exploration time for accelerator implementation on an FPGA by 10x, from days to only a few hours.

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arXiv2022

Flash-Cosmos: In-Flash Bulk Bitwise Operations Using Inherent Computation Capability of NAND Flash Memory

Bulk bitwise operations, i.e., bitwise operations on large bit vectors, are prevalent in a wide range of important application domains, including databases, graph processing, genome analysis, cryptography, and hyper-dimensional computing. In conventional systems, the performance and energy efficiency of bulk bitwise operations are bottlenecked by data movement between the compute units and the memory hierarchy. In-flash processing (i.e., processing data inside NAND flash chips) has a high potential to accelerate bulk bitwise operations by fundamentally reducing data movement through the entire memory hierarchy. We identify two key limitations of the state-of-the-art in-flash processing technique for bulk bitwise operations; (i) it falls short of maximally exploiting the bit-level parallelism of bulk bitwise operations; (ii) it is unreliable because it does not consider the highly error-prone nature of NAND flash memory. We propose Flash-Cosmos (Flash Computation with One-Shot Multi-Operand Sensing), a new in-flash processing technique that significantly increases the performance and energy efficiency of bulk bitwise operations while providing high reliability. Flash-Cosmos introduces two key mechanisms that can be easily supported in modern NAND flash chips: (i) Multi-Wordline Sensing (MWS), which enables bulk bitwise operations on a large number of operands with a single sensing operation, and (ii) Enhanced SLC-mode Programming (ESP), which enables reliable computation inside NAND flash memory. We demonstrate the feasibility of performing bulk bitwise operations with high reliability in Flash-Cosmos by testing 160 real 3D NAND flash chips. Our evaluation shows that Flash-Cosmos improves average performance and energy efficiency by 3.5x/32x and 3.3x/95x, respectively, over the state-of-the-art in-flash/outside-storage processing techniques across three real-world applications.

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arXiv2022

Machine Learning Training on a Real Processing-in-Memory System

Training machine learning algorithms is a computationally intensive process, which is frequently memory-bound due to repeatedly accessing large training datasets. As a result, processor-centric systems (e.g., CPU, GPU) suffer from costly data movement between memory units and processing units, which consumes large amounts of energy and execution cycles. Memory-centric computing systems, i.e., computing systems with processing-in-memory (PIM) capabilities, can alleviate this data movement bottleneck. Our goal is to understand the potential of modern general-purpose PIM architectures to accelerate machine learning training. To do so, we (1) implement several representative classic machine learning algorithms (namely, linear regression, logistic regression, decision tree, K-means clustering) on a real-world general-purpose PIM architecture, (2) characterize them in terms of accuracy, performance and scaling, and (3) compare to their counterpart implementations on CPU and GPU. Our experimental evaluation on a memory-centric computing system with more than 2500 PIM cores shows that general-purpose PIM architectures can greatly accelerate memory-bound machine learning workloads, when the necessary operations and datatypes are natively supported by PIM hardware. To our knowledge, our work is the first one to evaluate training of machine learning algorithms on a real-world general-purpose PIM architecture.

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arXiv2022

Exploiting Near-Data Processing to Accelerate Time Series Analysis

Time series analysis is a key technique for extracting and predicting events in domains as diverse as epidemiology, genomics, neuroscience, environmental sciences, economics, and more. Matrix profile, the state-of-the-art algorithm to perform time series analysis, computes the most similar subsequence for a given query subsequence within a sliced time series. Matrix profile has low arithmetic intensity, but it typically operates on large amounts of time series data. In current computing systems, this data needs to be moved between the off-chip memory units and the on-chip computation units for performing matrix profile. This causes a major performance bottleneck as data movement is extremely costly in terms of both execution time and energy. In this work, we present NATSA, the first Near-Data Processing accelerator for time series analysis. The key idea is to exploit modern 3D-stacked High Bandwidth Memory (HBM) to enable efficient and fast specialized matrix profile computation near memory, where time series data resides. NATSA provides three key benefits: 1) quickly computing the matrix profile for a wide range of applications by building specialized energy-efficient floating-point arithmetic processing units close to HBM, 2) improving the energy efficiency and execution time by reducing the need for data movement over slow and energy-hungry buses between the computation units and the memory units, and 3) analyzing time series data at scale by exploiting low-latency, high-bandwidth, and energy-efficient memory access provided by HBM. Our experimental evaluation shows that NATSA improves performance by up to 14.2x (9.9x on average) and reduces energy by up to 27.2x (19.4x on average), over the state-of-the-art multi-core implementation. NATSA also improves performance by 6.3x and reduces energy by 10.2x over a general-purpose NDP platform with 64 in-order cores.

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arXiv2022

Methodologies, Workloads, and Tools for Processing-in-Memory: Enabling the Adoption of Data-Centric Architectures

The increasing prevalence and growing size of data in modern applications have led to high costs for computation in traditional processor-centric computing systems. Moving large volumes of data between memory devices (e.g., DRAM) and computing elements (e.g., CPUs, GPUs) across bandwidth-limited memory channels can consume more than 60% of the total energy in modern systems. To mitigate these costs, the processing-in-memory (PIM) paradigm moves computation closer to where the data resides, reducing (and in some cases eliminating) the need to move data between memory and the processor. There are two main approaches to PIM: (1) processing-near-memory (PnM), where PIM logic is added to the same die as memory or to the logic layer of 3D-stacked memory; and (2) processing-using-memory (PuM), which uses the operational principles of memory cells to perform computation. Many works from academia and industry have shown the benefits of PnM and PuM for a wide range of workloads from different domains. However, fully adopting PIM in commercial systems is still very challenging due to the lack of tools and system support for PIM architectures across the computer architecture stack, which includes: (i) workload characterization methodologies and benchmark suites targeting PIM architectures; (ii) frameworks that can facilitate the implementation of complex operations and algorithms using the underlying PIM primitives; (iii) compiler support and compiler optimizations targeting PIM architectures; (iv) operating system support for PIM-aware virtual memory, memory management, data allocation, and data mapping; and (v) efficient data coherence and consistency mechanisms. Our goal in this work is to provide tools and system support for PnM and PuM architectures, aiming to ease the adoption of PIM in current and future systems.

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arXiv2022

SeGraM: A Universal Hardware Accelerator for Genomic Sequence-to-Graph and Sequence-to-Sequence Mapping

A critical step of genome sequence analysis is the mapping of sequenced DNA fragments (i.e., reads) collected from an individual to a known linear reference genome sequence (i.e., sequence-to-sequence mapping). Recent works replace the linear reference sequence with a graph-based representation of the reference genome, which captures the genetic variations and diversity across many individuals in a population. Mapping reads to the graph-based reference genome (i.e., sequence-to-graph mapping) results in notable quality improvements in genome analysis. Unfortunately, while sequence-to-sequence mapping is well studied with many available tools and accelerators, sequence-to-graph mapping is a more difficult computational problem, with a much smaller number of practical software tools currently available. We analyze two state-of-the-art sequence-to-graph mapping tools and reveal four key issues. We find that there is a pressing need to have a specialized, high-performance, scalable, and low-cost algorithm/hardware co-design that alleviates bottlenecks in both the seeding and alignment steps of sequence-to-graph mapping. To this end, we propose SeGraM, a universal algorithm/hardware co-designed genomic mapping accelerator that can effectively and efficiently support both sequence-to-graph mapping and sequence-to-sequence mapping, for both short and long reads. To our knowledge, SeGraM is the first algorithm/hardware co-design for accelerating sequence-to-graph mapping. SeGraM consists of two main components: (1) MinSeed, the first minimizer-based seeding accelerator; and (2) BitAlign, the first bitvector-based sequence-to-graph alignment accelerator. We demonstrate that SeGraM provides significant improvements for multiple steps of the sequence-to-graph and sequence-to-sequence mapping pipelines.

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