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Juan Jiménez

Publications and source records attributed to Juan Jiménez.

2 recordsLinked to original sources

Singularity-Free Guiding Vector Field over Bézier's Curves Applied to Rovers Path Planning and Path Following

This paper presents a guidance algorithm for solving the problem of following parametric paths, as well as a curvature-varying speed setpoint for land-based car-type wheeled mobile robots (WMRs). The guidance algorithm relies on Singularity-Free Guiding Vector Fields SF-GVF. This novel GVF approach expands the desired robot path and the Guiding vector field to a higher dimensional space, in which an angular control function can be found to ensure global asymptotic convergence to the desired parametric path while avoiding field singularities. In SF-GVF, paths should follow a parametric definition. This feature makes using Bezier's curves attractive to define the robot's desired patch. The curvature-varying speed setpoint, combined with the guidance algorithm, eases the convergence to the path when physical restrictions exist, such as minimal turning radius or maximal lateral acceleration. We provide theoretical results, simulations, and outdoor experiments using a WMR platform assembled with off-the-shelf components.

cs.RO↗

Universal scaling laws rule explosive growth inhuman cancers

Most physical and other natural systems are complex entities composed of a large number of interacting individual elements. It is a surprising fact that they often obey the so-called scaling laws relating an observable quantity with a measure of the size of the system. Here we describe the discovery of universal superlinear metabolic scaling laws in human cancers. This dependence underpins increasing tumour aggressiveness, due to evolutionary dynamics, which leads to an explosive growth as the disease progresses. We validated this dynamic using longitudinal volumetric data of different histologies from large cohorts of cancer patients. To explain our observations we put forward increasingly complex biologically-inspired mathematical models that captured the key processes governing tumor growth. Our models predicted that the emergence of superlinear allometric scaling laws is an inherently three-dimensional phenomenon. Moreover, the scaling laws thereby identified allowed us to define a set of metabolic metrics with prognostic value, thus providing added clinical utility to the base findings.

q-bio.TO↗