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Jue Hou

Publications and source records attributed to Jue Hou.

47 records · Page 3Linked to original sources

Implicit Profiling Estimation for Semiparametric Models with Bundled Parameters

Solving semiparametric models can be computationally challenging because the dimension of parameter space may grow large with increasing sample size. Classical Newton's method becomes quite slow and unstable with intensive calculation of the large Hessian matrix and its inverse. Iterative methods separately update parameters for finite dimensional component and infinite dimensional component have been developed to speed up single iteration, but they often take more steps until convergence or even sometimes sacrifice estimation precision due to sub-optimal update direction. We propose a computationally efficient implicit profiling algorithm that achieves simultaneously the fast iteration step in iterative methods and the optimal update direction in the Newton's method by profiling out the infinite dimensional component as the function of the finite dimensional component. We devise a first order approximation when the profiling function has no explicit analytical form. We show that our implicit profiling method always solve any local quadratic programming problem in two steps. In two numerical experiments under semiparametric transformation models and GARCH-M models, we demonstrated the computational efficiency and statistical precision of our implicit profiling method.

stat.CO↗

Note on the nonrelativistic $T\bar{T}$ deformation

In this paper, we present our study on the $T\bar{T}$-deformation of non-relativistic complex scalar field theory. We find the closed form of the deformed Lagrangian by using the perturbation and the method of characteristics. Furthermore we compute the exact energy spectrum of the deformed free theory by using the Brillouin-Wigner perturbation theory in an appropriate regularization scheme.

hep-th↗

Surrogate Assisted Semi-supervised Inference for High Dimensional Risk Prediction

Risk modeling with EHR data is challenging due to a lack of direct observations on the disease outcome, and the high dimensionality of the candidate predictors. In this paper, we develop a surrogate assisted semi-supervised-learning (SAS) approach to risk modeling with high dimensional predictors, leveraging a large unlabeled data on candidate predictors and surrogates of outcome, as well as a small labeled data with annotated outcomes. The SAS procedure borrows information from surrogates along with candidate predictors to impute the unobserved outcomes via a sparse working imputation model with moment conditions to achieve robustness against mis-specification in the imputation model and a one-step bias correction to enable interval estimation for the predicted risk. We demonstrate that the SAS procedure provides valid inference for the predicted risk derived from a high dimensional working model, even when the underlying risk prediction model is dense and the risk model is mis-specified. We present an extensive simulation study to demonstrate the superiority of our SSL approach compared to existing supervised methods. We apply the method to derive genetic risk prediction of type-2 diabetes mellitus using a EHR biobank cohort.

math.ST↗

Risk Prediction with Imperfect Survival Outcome Information from Electronic Health Records

Readily available proxies for time of disease onset such as time of the first diagnostic code can lead to substantial risk prediction error if performing analyses based on poor proxies. Due to the lack of detailed documentation and labor intensiveness of manual annotation, it is often only feasible to ascertain for a small subset the current status of the disease by a follow up time rather than the exact time. In this paper, we aim to develop risk prediction models for the onset time efficiently leveraging both a small number of labels on current status and a large number of unlabeled observations on imperfect proxies. Under a semiparametric transformation model for onset and a highly flexible measurement error models for proxy onset time, we propose the semisupervised risk prediction method by combining information from proxies and limited labels efficiently. From an initial estimator solely based on the labelled subset, we perform a one-step correction with the full data augmenting against a mean zero rank correlation score derived from the proxies. We establish the consistency and asymptotic normality of the proposed semi-supervised estimator and provide a resampling procedure for interval estimation. Simulation studies demonstrate that the proposed estimator performs well in finite sample. We illustrate the proposed estimator by developing a genetic risk prediction model for obesity using data from Partners Biobank Electronic Health Records (EHR).

stat.ME↗

Lax Connections in $T\bar{T}$-deformed Integrable Field Theories

In this work, we try to construct the Lax connections of $T\bar{T}$-deformed integrable field theories in two different ways. With reasonable assumptions, we make ansatz and find the Lax pairs in the $T\bar{T}$-deformed affine Toda theories and the principal chiral model by solving the Lax equations directly. This way is straightforward but maybe hard to apply for general models. We then make use of the dynamical coordinate transformation to read the Lax connection in the deformed theory from the undeformed one. We find that once the inverse of the transformation is available, the Lax connection can be read easily. We show the construction explicitly for a few classes of scalar models, and find consistency with the ones in the first way.

hep-th↗

Notes on index of quantum integrability

A quantum integrability index was proposed in \cite{KMS}. It systematizes the Goldschmidt and Witten's operator counting argument \cite{GW} by using the conformal symmetry. In this work we compute the quantum integrability indexes for the symmetric coset models ${SU(N)}/{SO(N)}$ and $SO(2N)/{SO(N)\times SO(N)}$. The indexes of these theories are all non-positive except for the case of ${SO(4)}/{SO(2)\times SO(2)}$. Moreover we extend the analysis to the theories with fermions and consider a concrete theory: the $\mathbb{CP}^N$ model coupled with a massless Dirac fermion. We find that the indexes for this class of models are non-positive as well.

hep-th↗

Asymmetric $λ$-deformed cosets

We study the integrable asymmetric $λ$-deformations of the $SO(n+1)/SO(n)$ coset models, following the prescription proposed in \cite{AsyLambda}. We construct all corresponding deformed geometries in an inductive way. Remarkably we find a $Z_2$ transformation which maps the asymmetric $λ$--deformed models to the symmetric $λ$--deformed models.

hep-th↗

Holographic Correlators on Integrable Superstrata

In this work, we study the $\frac{1}{8}$-BPS heavy-heavy-light-light correlators in the D1D5 CFT and its holographic dual. On the field theory side, we compute the fermionic four-point correlators at the free orbifold point. On the dual gravity side, we compute the correlators of the scalar operators in the supergravity limit of the D1D5 CFT. Following the strategy of \cite{Galliani:2017jlg}, the four-point function is converted into a two-point function in non-trivial geometries known as superstrata which are supergravity solutions preserving $1/8$ supersymmetries. We focus on a family of integrable superstrata, which allows us to compute the correlators perturbatively.

hep-th↗

Fine-Gray competing risks model with high-dimensional covariates: estimation and Inference

The purpose of this paper is to construct confidence intervals for the regression coefficients in the Fine-Gray model for competing risks data with random censoring, where the number of covariates can be larger than the sample size. Despite strong motivation from biomedical applications, a high-dimensional Fine-Gray model has attracted relatively little attention among the methodological or theoretical literature. We fill in this gap by developing confidence intervals based on a one-step bias-correction for a regularized estimation. We develop a theoretical framework for the partial likelihood, which does not have independent and identically distributed entries and therefore presents many technical challenges. We also study the approximation error from the weighting scheme under random censoring for competing risks and establish new concentration results for time-dependent processes. In addition to the theoretical results and algorithms, we present extensive numerical experiments and an application to a study of non-cancer mortality among prostate cancer patients using the linked Medicare-SEER data.

stat.ME↗

The Impact of Confounder Selection in Propensity Scores for Rare Events Data - with Applications to Birth Defects

Our work was motivated by a recent study on birth defects of infants born to pregnant women exposed to a certain medication for treating chronic diseases. Outcomes such as birth defects are rare events in the general population, which often translate to very small numbers of events in the unexposed group. As drug safety studies in pregnancy are typically observational in nature, we control for confounding in this rare events setting using propensity scores (PS). Using our empirical data, we noticed that the estimated odds ratio for birth defects due to exposure varied drastically depending on the specific approach used. The commonly used approaches with PS are matching, stratification, inverse probability weighting (IPW) and regression adjustment. The extremely rare events setting renders the matching or stratification infeasible. In addition, the PS itself may be formed via different approaches to select confounders from a relatively long list of potential confounders. We carried out simulation experiments to compare different combinations of approaches: IPW or regression adjustment, with 1) including all potential confounders without selection, 2) selection based on univariate association between the candidate variable and the outcome, 3) selection based on change in effects (CIE). The simulation showed that IPW without selection leads to extremely large variances in the estimated odds ratio, which help to explain the empirical data analysis results that we had observed. The simulation also showed that IPW with selection based on univariate association with the outcome is preferred over IPW with CIE. Regression adjustment has small variances of the estimated odds ratio regardless of the selection methods used.

stat.AP↗

A Nonparametric Maximum Likelihood Approach for Partially Observed Cured Data with Left Truncation and Right-Censoring

Partially observed cured data occur in the analysis of spontaneous abortion (SAB) in observational studies in pregnancy. In contrast to the traditional cured data, such data has an observable `cured' portion as women who do not abort spontaneously. The data is also subject to left truncate in addition to right-censoring because women may enter or withdraw from a study any time during their pregnancy. Left truncation in particular causes unique bias in the presence of a cured portion. In this paper, we study a cure rate model and develop a conditional nonparametric maximum likelihood approach. To tackle the computational challenge we adopt an EM algorithm making use of "ghost copies" of the data, and a closed form variance estimator is derived. Under suitable assumptions, we prove the consistency of the resulting estimator involving an unbounded cumulative baseline hazard function, as well as the asymptotic normality. Simulation results are carried out to evaluate the finite sample performance. We present the analysis of the motivating SAB study to illustrate the power of our model addressing both occurrence and timing of SAB, as compared to existing approaches in practice.

stat.ME↗