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Julia C. Walk

Publications and source records attributed to Julia C. Walk.

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Strategy-indifferent games of best choice

The game of best choice (or "secretary problem") is a model for making an irrevocable decision among a fixed number of candidate choices that are presented sequentially in random order, one at a time. Because the classically optimal solution is known to reject an initial sequence of candidates, a paradox emerges from the fact that candidates have an incentive to position themselves immediately after this cutoff which challenges the assumption that candidates arrive in uniformly random order. One way to resolve this is to consider games for which every (reasonable) strategy results in the same probability of success. In this work, we classify these "strategy-indifferent" games of best choice. It turns out that the probability of winning such a game is essentially the reciprocal of the expected number of left-to-right maxima in the full collection of candidate rank orderings. We present some examples of these games based on avoiding permutation patterns of size 3, which involves computing the distribution of left-to-right maxima in each of these pattern classes.

math.CO

Modeling the Effects of Multiple Myeloma on Kidney Function

Multiple myeloma (MM), a plasma cell cancer, is associated with many health challenges, including damage to the kidney by tubulointerstitial fibrosis. We develop a mathematical model which captures the qualitative behavior of the cell and protein populations involved. Specifically, we model the interaction between cells in the proximal tubule of the kidney, free light chains, renal fibroblasts, and myeloma cells. We analyze the model for steady-state solutions to find a mathematically and biologically relevant stable steady-state solution. This foundational model provides a representation of dynamics between key populations in tubulointerstitial fibrosis that demonstrates how these populations interact to affect patient prognosis in patients with MM and renal impairment.

q-bio.TO