arXiv subjects

Junfang Chen

Publications and source records attributed to Junfang Chen.

2 recordsLinked to original sources

arXiv2019

Brain state stability during working memory is explained by network control theory, modulated by dopamine D1/D2 receptor function, and diminished in schizophrenia

Dynamical brain state transitions are critical for flexible working memory but the network mechanisms are incompletely understood. Here, we show that working memory entails brainwide switching between activity states. The stability of states relates to dopamine D1 receptor gene expression while state transitions are influenced by D2 receptor expression and pharmacological modulation. Schizophrenia patients show altered network control properties, including a more diverse energy landscape and decreased stability of working memory representations.

q-bio.NC↗

arXiv2017

BioMM: Biologically-informed Multi-stage Machine learning for identification of epigenetic fingerprints

The identification of reproducible biological patterns from high-dimensional data is a bottleneck for understanding the biology of complex illnesses such as schizophrenia. To address this, we developed a biologically informed, multi-stage machine learning (BioMM) framework. BioMM incorporates biological pathway information to stratify and aggregate high-dimensional biological data. We demonstrate the utility of this method using genome-wide DNA methylation data and show that it substantially outperforms conventional machine learning approaches. Therefore, the BioMM framework may be a fruitful machine learning strategy in high-dimensional data and be the basis for future, integrative analysis approaches.

q-bio.QM↗