SearcharxivSearch

arXiv subjects

Junjun Mao

Publications and source records attributed to Junjun Mao.

2 recordsLinked to original sources

Task-disentangled Low-Rank Adaptation for Versatile Audio-visual Multi-modal Learning Tasks within a Unified Framework

Inspired by human multi-modal perception, Audio-Visual Multi-Modal Learning (AVMML) integrates auditory and visual information to leverage complementary cross-modal cues, enabling more robust and comprehensive scene perception. Existing studies predominantly tackle each AVMML task in isolation, which stands in stark contrast to humans' unified cognitive capacity for handling versatile perception. However, naive joint training across multiple AVMML tasks often suffers from mutual interference, arising from the intricate inter-task relationships. To address this, we propose a unified framework that simultaneously accommodates versatile AVMML tasks. Specifically, benefiting from powerful representation and generalization capabilities of large language models, we design a task-disentangled Low-Rank Adaptation (LoRA) mechanism that enables dynamic integration of both task-specific and task-shared knowledge, thereby facilitating effective multi-task collaboration. The proposed task-disentangled LoRA comprises three components: a task-general low-rank matrix, task-specific modulation matrices, and cross-task collaboration experts, which respectively capture universal audio-visual knowledge, decouple task-specific pattern, and exploit inherent inter-task correlations. By unifying explicit collaboration from both model and task perspectives, our approach not only surpasses existing unified audio-visual models across multiple AVMML tasks, but also outperforms most task-specific models on certain AVMML tasks.

cs.MM

Time-dependent Clearance of Cyclosporine in Adult Renal Transplant Recipients: A Population Pharmacokinetic Perspective

Aim The pharmacokinetic (PK) properties of cyclosporine (CsA) in renal transplant recipients are patient- and time-dependent. Knowledge of this time-related variability is necessary to maintain or achieve CsA target exposure. Here, we aimed to identify factors explaining variabilities in CsA PK properties and characterise time-dependent clearance (CL/F) by performing a comprehensive analysis of CsA PK factors using population PK (popPK) modelling of long-term follow-up data from our institution. Methods In total, 3,674 whole-blood CsA concentrations from 183 patients who underwent initial renal transplantation were analysed using nonlinear mixed-effects modelling. The effects of potential covariates were selected according to a previous report and well-accepted theoretical mechanisms. Model-informed individualised therapeutic regimens were also conducted. Results A two-compartment model adequately described the data and the estimated mean CsA CL/F was 32.6 L h-1 (5%). Allometrically scaled body size, haematocrit (HCT) level, CGC haplotype carrier status, and postoperative time may contribute to CsA PK variability. The CsA bioavailability in patients receiving a prednisolone dose (PD) of 80 mg was 20.6% lower than that in patients receiving 20 mg. A significant decrease (52.6%) in CL/F was observed as the HCT increased from 10.5% to 60.5%. The CL/F of the non-CGC haplotype carrier was 14.4% lower than that of the CGC haplotype carrier at 3 months post operation. CsA dose adjustments should be considered in different postoperative periods. Conclusions By monitoring body size, HCT, PD, and CGC haplotype, changes in CsA CL/F over time could be predicted. Such information could be used to optimise CsA therapy.

q-bio.TO