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Junwen Xia

Publications and source records attributed to Junwen Xia.

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Statistical Inference for Smoothed Support Vector Machines in High Dimensions: From Offline to Online Data

High-dimensional classification problems often rely on the Lasso-penalized linear Support Vector Machines (SVMs). However, the double non-smoothness induced by the hinge loss and Lasso penalty in this model makes statistical inference challenging and impedes computational efficiency. In this paper, we propose a unified inference framework in both offline and online settings. In the offline case, by applying a convolution smoothing technique to the hinge loss, we construct a debiased estimator that eliminates the shrinkage bias, thereby building a valid confidence interval. For online streaming data, we develop a real-time estimator and inference procedure that relies only on summary statistics of historical data. Theoretically, we provide rigorous proofs for the asymptotic normality of our offline and online debiased estimators. Simulation studies and real data applications demonstrate that our methods achieve valid statistical inference and improved computational efficiency.

stat.ME

Successive classification learning for estimating quantile optimal treatment regimes

Quantile optimal treatment regimes (OTRs) aim to assign treatments that maximize a specified quantile of patients' outcomes. Compared to treatment regimes that target the mean outcomes, quantile OTRs offer fairer regimes when a lower quantile is selected, as it improves outcomes for vulnerable patients. In this paper, we propose a novel method for estimating quantile OTRs by reformulating the problem as a successive classification task, solvable via training a sequence of classifiers, each successive classifier built on the output of its predecessors. This reformulation enables us to leverage the powerful machine learning technique to enhance computational efficiency and handle complex decision boundaries. We also investigate the estimation of quantile OTRs when outcomes are discrete, a setting that has received limited attention in the literature. A key challenge is that direct extensions of existing methods to discrete outcomes often lead to inconsistency and ineffectiveness issues. To overcome this, we introduce a smoothing technique that maps discrete outcomes to continuous surrogates, enabling consistent and effective estimation. We provide theoretical guarantees to support our methodology, and demonstrate its superior performance through comprehensive simulation studies and real-data analysis.

stat.ME

Doubly robust estimation of optimal treatment regimes for survival data using an instrumental variable

In survival contexts, substantial literature exists on estimating optimal treatment regimes, where treatments are assigned based on personal characteristics to maximize the survival probability. These methods assume that a set of covariates is sufficient to deconfound the treatment-outcome relationship. However, this assumption can be limited in observational studies or randomized trials in which non-adherence occurs. Therefore, we propose a novel approach to estimating optimal treatment regimes when certain confounders are unobservable and a binary instrumental variable is available. Specifically, via a binary instrumental variable, we propose a semiparametric estimator for optimal treatment regimes by maximizing a Kaplan-Meier-like estimator of the survival function. Furthermore, to increase resistance to model misspecification, we construct novel doubly robust estimators. Since the estimators of the survival function are jagged, we incorporate kernel smoothing methods to improve performance. Under appropriate regularity conditions, the asymptotic properties are rigorously established. Moreover, the finite sample performance is evaluated through simulation studies. Finally, we illustrate our method using data from the National Cancer Institute's prostate, lung, colorectal, and ovarian cancer screening trial.

stat.ME