arXiv subjects

K. Garikipati

Publications and source records attributed to K. Garikipati.

21 records · Page 2Linked to original sources

arXiv2003

A continuum treatment of growth in biological tissue: The coupling of mass transport and mechanics

Growth (and resorption) of biological tissue is formulated in the continuum setting. The treatment is macroscopic, rather than cellular or sub-cellular. Certain assumptions that are central to classical continuum mechanics are revisited, the theory is reformulated, and consequences for balance laws and constitutive relations are deduced. The treatment incorporates multiple species. Sources and fluxes of mass, and terms for momentum and energy transfer between species are introduced to enhance the classical balance laws. The transported species include: (\romannumeral 1) a fluid phase, and (\romannumeral 2) the precursors and byproducts of the reactions that create and break down tissue. A notable feature is that the full extent of coupling between mass transport and mechanics emerges from the thermodynamics. Contributions to fluxes from the concentration gradient, chemical potential gradient, stress gradient, body force and inertia have not emerged in a unified fashion from previous formulations of the problem. The present work demonstrates these effects via a physically-consistent treatment. The presence of multiple, interacting species requires that the formulation be consistent with mixture theory. This requirement has far-reaching consequences. A preliminary numerical example is included to demonstrate some aspects of the coupled formulation.

q-bio.QM↗

arXiv2003

A discontinuous Galerkin formulation for a strain gradient-dependent damage model

The numerical solution of strain gradient-dependent continuum problems has been dogged by continuity demands on the basis functions. For most commonly accepted models, solutions using the finite element method demand $C^{1}$ continuity of the shape functions. Here, recent development in discontinuous Galerkin methods are explored and exploited for the solution of a prototype nonlinear strain gradient dependent continuum model. A formulation is developed that allows the rigorous solution of a strain gradient damage model using standard $C^{0}$ shape functions. The formulation is tested in one-dimension for the simplest possible finite element formulation: piecewise linear displacement and constant (on elements) internal variable. Numerical results are shown to compare excellently with a benchmark solution. The results are remarkable given the simplicity of the proposed formulation.

math.NA↗

arXiv2003

Material forces in the context of biotissue remodelling

Remodelling of biological tissue, due to changes in microstructure, is treated in the continuum mechanical setting. Microstructural change is expressed as an evolution of the reference configuration. This evolution is expressed as a point-to-point map from the reference configuration to a remodelled configuration. A ``preferred'' change in configuration is considered in the form of a globally incompatible tangent map. This field could be experimentally determined, or specified from other insight. Issues of global compatibility and evolution equations for the resulting configurations are addressed. It is hypothesized that the tissue reaches local equilibrium with respect to changes in microstructure. A governing differential equation and boundary conditions are obtained for the microstructural changes by posing the problem in a variational setting. The Eshelby stress tensor, a separate configurational stress, and thermodynamic driving (material) forces arise in this formulation, which is recognized as describing a process of self-assembly. An example is presented to illustrate the theoretical framework.

q-bio.QM↗