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Kai-Chun Lin

Publications and source records attributed to Kai-Chun Lin.

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Probabilistic approximate optimization using single-photon avalanche diode arrays

Combinatorial optimization problems are central to science and engineering and specialized hardware from quantum annealers to classical Ising machines are being actively developed to address them. These systems typically sample from a fixed energy landscape defined by the problem Hamiltonian encoding the discrete optimization problem. The recently introduced Probabilistic Approximate Optimization Algorithm (PAOA) takes a different approach: it treats the optimization landscape itself as variational, iteratively learning circuit parameters from samples. Here, we demonstrate PAOA on a 64$\times$64 perimeter-gated single-photon avalanche diode (pgSPAD) array fabricated in 0.35 $\mu$m CMOS, the first realization of the algorithm using intrinsically stochastic nanodevices. Each p-bit exhibits a device-specific, asymmetric (Gompertz-type) activation function due to dark-count variability. Rather than calibrating devices to enforce a uniform symmetric (logistic/tanh) activation, PAOA learns around device variations, absorbing residual activation and other mismatches into the variational parameters. On canonical 26-spin Sherrington-Kirkpatrick instances, PAOA achieves high approximation ratios with $2p$ parameters ($p$ up to 17 layers), and pgSPAD-based inference closely tracks CPU simulations. These results show that variational learning can accommodate the non-idealities inherent to nanoscale devices, suggesting a practical path toward larger-scale, CMOS-compatible probabilistic computers.

cs.ET

Analysis of bio-electro-chemical signals from passive sweat-based wearable electro-impedance spectroscopy (EIS) towards assessing blood glucose modulations

There has been a recent tremendous interest in label-free detection of biomarkers which is a critical enabler of point-of-need diagnostics. A low-power, small form factor, multiplexed wearable system is proposed for continuous detection of glucose in passively expressed sweat using electrochemical impedance spectroscopy (EIS) measurement. The wearable EIS system consists of a sensing analog front end integrated with low-volume (1-5 $μ$L) ultra-sensitive flexible biosensors. A passive sweat sensor was designed to integrate a glucose oxidase electrochemical system on active semiconducting material. The non-faradaic EIS response of the biosensor was used to calibrate the analog front end response using ratiometric Discrete Fourier Transform (DFT) for a shorter measurement time. In this work, a stringent assessment of a continuous glucose sensing platform is performed in a bottom-up approach, going from the biosensor to the system to the interaction with a human subject. The active semiconductor-based biosensors are dosed with glucose concentrations ranging from 5-200 mg/dL and detection is performed using the analog front end. In addition, a detailed analysis of battery life and performance of a wearable EIS system is discussed to define a figure of merit for an optimally integrated design. Moreover, a continuous glucose detection test is performed on a healthy human subject cohort to investigate the stability of the sensor-system mechanism for an 8-hour period, and a time-series-based, auto-regressive (AR) model was created for the system.

eess.SP