arXiv subjects

Kaicheng Li

Publications and source records attributed to Kaicheng Li.

3 recordsLinked to original sources

arXiv2025

Generative design and validation of therapeutic peptides for glioblastoma based on a potential target ATP5A

Glioblastoma (GBM) remains the most aggressive tumor, urgently requiring novel therapeutic strategies. Here, we present a dry-to-wet framework combining generative modeling and experimental validation to optimize peptides targeting ATP5A, a potential peptide-binding protein for GBM. Our framework introduces the first lead-conditioned generative model, which focuses exploration on geometrically relevant regions around lead peptides and mitigates the combinatorial complexity of de novo methods. Specifically, we propose POTFlow, a \underline{P}rior and \underline{O}ptimal \underline{T}ransport-based \underline{Flow}-matching model for peptide optimization. POTFlow employs secondary structure information (e.g., helix, sheet, loop) as geometric constraints, which are further refined by optimal transport to produce shorter flow paths. With this design, our method achieves state-of-the-art performance compared with five popular approaches. When applied to GBM, our method generates peptides that selectively inhibit cell viability and significantly prolong survival in a patient-derived xenograft (PDX) model. As the first lead peptide-conditioned flow matching model, POTFlow holds strong potential as a generalizable framework for therapeutic peptide design.

q-bio.BM↗

arXiv2022

Learning Polysemantic Spoof Trace: A Multi-Modal Disentanglement Network for Face Anti-spoofing

Along with the widespread use of face recognition systems, their vulnerability has become highlighted. While existing face anti-spoofing methods can be generalized between attack types, generic solutions are still challenging due to the diversity of spoof characteristics. Recently, the spoof trace disentanglement framework has shown great potential for coping with both seen and unseen spoof scenarios, but the performance is largely restricted by the single-modal input. This paper focuses on this issue and presents a multi-modal disentanglement model which targetedly learns polysemantic spoof traces for more accurate and robust generic attack detection. In particular, based on the adversarial learning mechanism, a two-stream disentangling network is designed to estimate spoof patterns from the RGB and depth inputs, respectively. In this case, it captures complementary spoofing clues inhering in different attacks. Furthermore, a fusion module is exploited, which recalibrates both representations at multiple stages to promote the disentanglement in each individual modality. It then performs cross-modality aggregation to deliver a more comprehensive spoof trace representation for prediction. Extensive evaluations are conducted on multiple benchmarks, demonstrating that learning polysemantic spoof traces favorably contributes to anti-spoofing with more perceptible and interpretable results.

cs.CV↗

arXiv2019

CN-CELEB: a challenging Chinese speaker recognition dataset

Recently, researchers set an ambitious goal of conducting speaker recognition in unconstrained conditions where the variations on ambient, channel and emotion could be arbitrary. However, most publicly available datasets are collected under constrained environments, i.e., with little noise and limited channel variation. These datasets tend to deliver over optimistic performance and do not meet the request of research on speaker recognition in unconstrained conditions. In this paper, we present CN-Celeb, a large-scale speaker recognition dataset collected `in the wild'. This dataset contains more than 130,000 utterances from 1,000 Chinese celebrities, and covers 11 different genres in real world. Experiments conducted with two state-of-the-art speaker recognition approaches (i-vector and x-vector) show that the performance on CN-Celeb is far inferior to the one obtained on VoxCeleb, a widely used speaker recognition dataset. This result demonstrates that in real-life conditions, the performance of existing techniques might be much worse than it was thought. Our database is free for researchers and can be downloaded from http://project.cslt.org.

eess.AS↗