arXiv subjects

Kaiyuan Gao

Publications and source records attributed to Kaiyuan Gao.

At least 19 recordsLinked to original sources

arXiv2026

Separators in Enhancing Autoregressive Pretraining for Vision Mamba

The state space model Mamba has recently emerged as a promising paradigm in computer vision, attracting considerable attention for its efficient handling of long-sequence tasks. Its inherent causal structure makes it particularly well suited for autoregressive pretraining. However, existing autoregressive pretraining methods in vision are largely limited to short-sequence settings and may not fully use Mamba's capacity to model longer contexts. To investigate this setting, we introduce SeparaTors for AutoRegressive pretraining (STAR), a new autoregressive pretraining method for Vision Mamba that explicitly marks the boundaries between different images. STAR increases the patch-token sequence length from 144 to 640 by packing four images and four separator clusters. This is approximately $4.4\times$ the ARM patch-token sequence length. The increase is achieved without changing the resolution of any individual image: we use $192\times192$ inputs for autoregressive pretraining and $224\times224$ inputs for downstream classification fine-tuning. With this long-sequence pretraining scheme, STAR-B achieves 83.5\% EMA top-1 accuracy on ImageNet-1K after 1,600 epochs of pretraining. The learned representation also transfers beyond in-distribution classification: compared with ARM, STAR-B improves COCO box AP from 46.11 to 46.84 and mask AP from 40.74 to 41.45, while raising the mean top-1 accuracy across five ImageNet robustness benchmarks from 55.1\% to 56.8\%. Under the evaluated four-image setting, these results indicate that separator-based long-sequence pretraining improves recognition robustness and dense visual prediction relative to ARM.

cs.CV↗

arXiv2026

Qwen-Image-Flash: Rethinking the Training Recipe for Few-Step Distillation

Few-step distillation has emerged as a critical component in the development of advanced visual generative foundation models, substantially reducing inference overhead while enabling real-time generation and cost-efficient deployment across a broad range of practical scenarios. However, prior work has predominantly focused on advancing training objectives, while comparatively overlooking the training recipe, which has become increasingly critical in the era of large-scale foundation models. In this work, we systematically revisit the training recipe under the well-established distribution matching distillation (DMD) framework for both text-to-image generation and image editing, focusing on three key dimensions: training data composition, teacher guidance within DMD, and task mixture. Our empirical analysis reveals several non-obvious and counterintuitive phenomena, ultimately motivating the development of Qwen-Image-Flash. These findings highlight that effective few-step distillation depends not only on carefully designed objectives, but also on a principled training recipe.

cs.CV↗

arXiv2026

Qwen-Image-Agent: Bridging the Context Gap in Real-World Image Generation

While text-to-image (T2I) models have achieved remarkable progress, they struggle with real-world requests that are often underspecified, implicit, or dependent on up-to-date knowledge. We identify this challenge as the Context Gap: the mismatch between the user context and the sufficient generation context for T2I models. To bridge this gap, we propose Qwen-Image-Agent, a unified agentic framework that integrates plan, reason, search, memory and feedback in a context-centric manner. Qwen-Image-Agent treats user input as partial context and progressively constructs the generation context through Context-Aware Planning and Context Grounding. Specifically, Context-Aware Planning identifies missing context and plans how it should be acquired and used, while Context Grounding gathers this context from reason, search, memory, and feedback. To evaluate agentic image generation, we further introduce Image Agent Bench (IA-Bench), a benchmark covering four core image agent capabilities: Plan, Reason, Search, and Memory. Experiments on IA-Bench, Mindbench and WISE-Verified show that Qwen-Image-Agent outperforms strong baselines and achieves state-of-the-art performance.

cs.CV↗

arXiv2026

Qwen-Image-Bench: From Generation to Creation in Text-to-Image Evaluation

Text-to-Image generation has evolved from basic image synthesis into a frequently used core capability in professional creative workflows, where simple text-image alignment can no longer satisfy users' pressing demands for faithful real-world reconstruction and genuine creative expression. Existing benchmarks, however, remain anchored in these foundational criteria and do not yet capture the nuanced capabilities that matter in authentic artistic practice, making it difficult to reliably distinguish state-of-the-art T2I models. To address the gap, we introduce Qwen-Image-Bench, a creator-centric benchmark co-designed with professional artists and grounded in real-world creation scenarios. Qwen-Image-Bench enriches conventional evaluation with two application-driven dimensions: Real-world Fidelity and Creative Generation. Drawing on the staged reasoning inherent in professional artistic workflows, we organize these five pillars into a top-down hierarchical taxonomy that further decomposes into 23 second-level sub-capabilities and 56 third-level verifiable rubrics. To ensure broad coverage, we curate 1000 stratified prompts with each prompt jointly exercising more than four fine-grained facets across multiple pillars. We train a unified judge model Q-Judger based on Qwen3.6-27B, supervised by 80 professional annotators from global art academies under blind labeling and triple-review protocols, that scores every image across all 56 verifiable facets, producing fine-grained, rubric-grounded, and fully attributable diagnostics rather than a single opaque score. Empirically, Qwen-Image-Bench reliably distinguishes leading T2I models, achieving the greatest separation on the two application-driven dimensions of Real-world Fidelity and Creative Generation where existing benchmarks provide little insight, while also providing a trustworthy optimization signal for production-level T2I development.

cs.CV↗

arXiv2026

Qwen-Image-2.0-RL Technical Report

We present Qwen-Image-2.0-RL, a post-training pipeline that applies reinforcement learning from human feedback (RLHF) and on-policy distillation (OPD) to improve both the visual quality and instruction-following capability of the Qwen-Image-2.0 diffusion model. To provide reliable reward signals, we construct task-specific composite reward models by fine-tuning vision-language models with a pointwise scoring paradigm and chain-of-thought reasoning. For text-to-image generation, the reward models cover alignment, aesthetics, and portrait fidelity dimensions. For image editing tasks, the reward system addresses instruction-following accuracy and face identity preservation. Building on this reward system, we develop a scalable GRPO-based RL training framework, incorporating a hybrid classifier-free guidance (CFG) strategy to preserve pre-trained knowledge, prompt curation via intra-group reward range filtering, and per-category reward weight calibration. To merge the task-specialized RL policies for T2I and editing, we propose on-policy distillation as the final training stage, which consolidates multiple teachers into a single student model through trajectory-level velocity matching. Extensive evaluation shows that Qwen-Image-2.0-RL achieves 57.84 overall score on Qwen-Image-Bench (+2.61 over the base model), Elo ratings of 1193 in text-to-image arena (+78) and 1349 in image edit arena (+93), demonstrating consistent gains in aesthetic quality, prompt adherence, and editing accuracy.

cs.CV↗

arXiv2026

Study on the Cabibbo-favored ${\overline B}_{d,s}$ ${\to}$ $D_{d,s}^{(*)+}S^{-}$ weak decays in QCD factorization

Motivated by recent experimental progress and theoretical developments, we investigate the Cabibbo-favored $b\to c$ governed ${\overline B}_{d,s}$ ${\to}$ $D_{d,s}^{(*)+}S^{-}$~($S$$=$$K_0^*(1430)$, $a_0(1450)$) weak decays by considering the next-to-leading (NLO) contributions within QCDF framework. With the updated values of $B_{(s)}\to D_{(s)}^{(*)}$ transition form factors obtained from a covariant light-front quark model, branching ratios are estimated in two scenarios for scalar mesons. It is found that the branching ratios for ${\overline B}^0{\to}D^{+}{a_0^-}$ and ${\overline B}_{s}^0{\to}D_{s}^{+}{a_0^-}$ decays can reach up to the order of ${\cal O}(10^{-4})$ in scenario-2 by assuming that the scalar mesons are lowest-lying p-wave states, which deserve high-priority experimental searches and may be observed in the ongoing LHCb and SuperKEKB experiments.

hep-ph↗

arXiv2026

Qwen-RobotWorld Technical Report: Unifying Embodied World Modeling through Language-Conditioned Video Generation

We introduce Qwen-RobotWorld, a language-conditioned video world model for embodied intelligence. With natural language as a unified action interface, it predicts physically grounded future visual trajectories from current observations across robotic manipulation, autonomous driving, indoor navigation, and human-to-robot transfer. This unified formulation provides three promising application directions: synthetic data generation for policy training augmentation, scalable virtual environments for policy evaluation, and language-guided planning signals for downstream robot control. This is achieved through a three-part design: a) Double-Stream MMDiT with MLLM Action Encoding, where a 60-layer double-stream diffusion transformer couples frozen Qwen2.5-VL semantics with video-VAE latents through layer-wise joint attention; b) Embodied World Knowledge (EWK), an 8.6M video-text corpus (200M+ frames) with action-language mapping over 20+ embodiments and 500+ action categories; and c) General+Expert Progressive Curriculum, a two-stage training strategy that first learns general visual priors and then injects embodied specialization under a shared language interface. Extensive results show strong competitiveness: ranks 1st overall on EWMBench and DreamGen Bench, outperforms all open-source models on WorldModelBench and PBench. Additional zero-shot analyses on RoboTwin-IF benchmark further support robust generalization and multi-view consistency.

cs.CV↗

arXiv2026

Quotient-Space Diffusion Models

Diffusion-based generative models have reformed generative AI, and also enabled new capabilities in the science domain, e.g., fast generation of 3D structures of molecules. In such tasks, there is often a symmetry in the system, identifying elements that can be converted by certain transformations as equivalent. Equivariant diffusion models guarantee a symmetric distribution, but miss the opportunity to make learning easier, while alignment-based simplification attempts fail to preserve the target distribution. In this work, we develop quotient-space diffusion models, a principled generative framework to fully handle and leverage symmetry. By viewing the intrinsic generation process on the quotient space, the exact construction that removes symmetry redundancy, the framework simplifies learning by allowing model output to have an arbitrary intra-equivalence-class movement, while generating the correct symmetric target distribution with guarantee. We instantiate the framework for molecular structure generation which follows $\mathrm{SE}(3)$ (rigid-body movement) symmetry. It improves the performance over equivariant diffusion models and outperforms alignment-based methods universally for small molecules and proteins, representing a new framework that surpasses previous symmetry treatments in generative models.

cs.LG↗

arXiv2026

Qwen-Image-VAE-2.0 Technical Report

We present Qwen-Image-VAE-2.0, a suite of high-compression Variational Autoencoders (VAEs) that achieve significant advances in both reconstruction fidelity and diffusability. To address the reconstruction bottlenecks of high compression, we adopt an improved architecture featuring Global Skip Connections (GSC) and expanded latent channels. Moreover, we scale training to billions of images and incorporate a synthetic rendering engine to improve performance in text-rich scenarios. To tackle the convergence challenges of high-dimensional latent space, we implement an enhanced semantic alignment strategy to make the latent space highly amenable to diffusion modeling. To optimize computational efficiency, we leverage an asymmetric and attention-free encoder-decoder backbone to minimize encoding overhead. We present a comprehensive evaluation of Qwen-Image-VAE-2.0 on public reconstruction benchmarks. To evaluate performance in text-rich scenarios, we propose OmniDoc-TokenBench, a new benchmark comprising a diverse collection of real-world documents coupled with specialized OCR-based evaluation metrics. Qwen-Image-VAE-2.0 achieves state-of-the-art reconstruction performance, demonstrating exceptional capabilities in both general domains and text-rich scenarios at high compression ratio. Furthermore, downstream DiT experiments reveal our models possess superior diffusability, significantly accelerating convergence compared to existing high-compression baselines. These establish Qwen-Image-VAE-2.0 as a leading model with high compression, superior reconstruction, and exceptional diffusability.

cs.CV↗

arXiv2026

Qwen-Image-2.0 Technical Report

We present Qwen-Image-2.0, an omni-capable image generation foundation model that unifies high-fidelity generation and precise image editing within a single framework. Despite recent progress, existing models still struggle with ultra-long text rendering, multilingual typography, high-resolution photorealism, robust instruction following, and efficient deployment, especially in text-rich and compositionally complex scenarios. Qwen-Image-2.0 addresses these challenges by coupling Qwen3-VL as the condition encoder with a Multimodal Diffusion Transformer for joint condition-target modeling, supported by large-scale data curation and a customized multi-stage training pipeline. This enables strong multimodal understanding while preserving flexible generation and editing capabilities. The model supports instructions of up to 1K tokens for generating text-rich content such as slides, posters, infographics, and comics, while significantly improving multilingual text fidelity and typography. It also enhances photorealistic generation with richer details, more realistic textures, and coherent lighting, and follows complex prompts more reliably across diverse styles. Extensive human evaluations show that Qwen-Image-2.0 substantially outperforms previous Qwen-Image models in both generation and editing, marking a step toward more general, reliable, and practical image generation foundation models.

cs.CV↗

arXiv2026

BioMiner: A Multi-modal System for Automated Mining of Protein-Ligand Bioactivity Data from Literature

Protein-ligand bioactivity data published in the literature are essential for drug discovery, yet manual curation struggles to keep pace with rapidly growing literature. Automated bioactivity extraction remains challenging because it requires not only interpreting biochemical semantics distributed across text, tables, and figures, but also reconstructing chemically exact ligand structures (e.g., Markush structures). To address this bottleneck, we introduce BioMiner, a multi-modal extraction framework that explicitly separates bioactivity semantic interpretation from ligand structure construction. Within BioMiner, bioactivity semantics are inferred through direct reasoning, while chemical structures are resolved via a chemical-structure-grounded visual semantic reasoning paradigm, in which multi-modal large language models operate on chemically grounded visual representations to infer inter-structure relationships, and exact molecular construction is delegated to domain chemistry tools. For rigorous evaluation and method development, we further establish BioVista, a comprehensive benchmark comprising 16,457 bioactivity entries curated from 500 publications. BioMiner validates its extraction ability and provides a quantitative baseline, achieving an F1 score of 0.32 for bioactivity triplets. BioMiner's practical utility is demonstrated via three applications: (1) extracting 82,262 data from 11,683 papers to build a pre-training database that improves downstream models performance by 3.9%; (2) enabling a human-in-the-loop workflow that doubles the number of high-quality NLRP3 bioactivity data, helping 38.6% improvement over 28 QSAR models and identification of 16 hit candidates with novel scaffolds; and (3) accelerating protein-ligand complex bioactivity annotation, achieving a 5.59-fold speed increase and 5.75% accuracy improvement over manual workflows in PoseBusters dataset.

cs.AI↗

arXiv2025

Qwen-Image-Layered: Towards Inherent Editability via Layer Decomposition

Recent visual generative models often struggle with consistency during image editing due to the entangled nature of raster images, where all visual content is fused into a single canvas. In contrast, professional design tools employ layered representations, allowing isolated edits while preserving consistency. Motivated by this, we propose \textbf{Qwen-Image-Layered}, an end-to-end diffusion model that decomposes a single RGB image into multiple semantically disentangled RGBA layers, enabling \textbf{inherent editability}, where each RGBA layer can be independently manipulated without affecting other content. To support variable-length decomposition, we introduce three key components: (1) an RGBA-VAE to unify the latent representations of RGB and RGBA images; (2) a VLD-MMDiT (Variable Layers Decomposition MMDiT) architecture capable of decomposing a variable number of image layers; and (3) a Multi-stage Training strategy to adapt a pretrained image generation model into a multilayer image decomposer. Furthermore, to address the scarcity of high-quality multilayer training images, we build a pipeline to extract and annotate multilayer images from Photoshop documents (PSD). Experiments demonstrate that our method significantly surpasses existing approaches in decomposition quality and establishes a new paradigm for consistent image editing. Our code and models are released on \href{https://github.com/QwenLM/Qwen-Image-Layered}{https://github.com/QwenLM/Qwen-Image-Layered}

cs.CV↗

arXiv2025

Leveraging Biomolecule and Natural Language through Multi-Modal Learning: A Survey

The integration of biomolecular modeling with natural language (BL) has emerged as a promising interdisciplinary area at the intersection of artificial intelligence, chemistry and biology. This approach leverages the rich, multifaceted descriptions of biomolecules contained within textual data sources to enhance our fundamental understanding and enable downstream computational tasks such as biomolecule property prediction. The fusion of the nuanced narratives expressed through natural language with the structural and functional specifics of biomolecules described via various molecular modeling techniques opens new avenues for comprehensively representing and analyzing biomolecules. By incorporating the contextual language data that surrounds biomolecules into their modeling, BL aims to capture a holistic view encompassing both the symbolic qualities conveyed through language as well as quantitative structural characteristics. In this review, we provide an extensive analysis of recent advancements achieved through cross modeling of biomolecules and natural language. (1) We begin by outlining the technical representations of biomolecules employed, including sequences, 2D graphs, and 3D structures. (2) We then examine in depth the rationale and key objectives underlying effective multi-modal integration of language and molecular data sources. (3) We subsequently survey the practical applications enabled to date in this developing research area. (4) We also compile and summarize the available resources and datasets to facilitate future work. (5) Looking ahead, we identify several promising research directions worthy of further exploration and investment to continue advancing the field. The related resources and contents are updating in https://github.com/QizhiPei/Awesome-Biomolecule-Language-Cross-Modeling.

cs.CL↗

arXiv2025

UniGenX: a unified generative foundation model that couples sequence, structure and function to accelerate scientific design across proteins, molecules and materials

Function in natural systems arises from one-dimensional sequences forming three-dimensional structures with specific properties. However, current generative models suffer from critical limitations: training objectives seldom target function directly, discrete sequences and continuous coordinates are optimized in isolation, and conformational ensembles are under-modeled. We present UniGenX, a unified generative foundation model that addresses these gaps by co-generating sequences and coordinates under direct functional and property objectives across proteins, molecules, and materials. UniGenX represents heterogeneous inputs as a mixed stream of symbolic and numeric tokens, where a decoder-only autoregressive transformer provides global context and a conditional diffusion head generates numeric fields steered by task-specific tokens. Besides the new high SOTAs on structure prediction tasks, the model demonstrates state-of-the-art or competitive performance for the function-aware generation across domains: in materials, it achieves "conflicted" multi-property conditional generation, yielding 436 crystal candidates meeting triple constraints, including 11 with novel compositions; in chemistry, it sets new benchmarks on five property targets and conformer ensemble generation on GEOM; and in biology, it improves success in modeling protein induced fit (RMSD < 2 Å) by over 23-fold and enhances EC-conditioned enzyme design. Ablation studies and cross-domain transfer substantiate the benefits of joint discrete-continuous training, establishing UniGenX as a significant advance from prediction to controllable, function-aware generation.

cs.LG↗

arXiv2025

Qwen-Image Technical Report

We present Qwen-Image, an image generation foundation model in the Qwen series that achieves significant advances in complex text rendering and precise image editing. To address the challenges of complex text rendering, we design a comprehensive data pipeline that includes large-scale data collection, filtering, annotation, synthesis, and balancing. Moreover, we adopt a progressive training strategy that starts with non-text-to-text rendering, evolves from simple to complex textual inputs, and gradually scales up to paragraph-level descriptions. This curriculum learning approach substantially enhances the model's native text rendering capabilities. As a result, Qwen-Image not only performs exceptionally well in alphabetic languages such as English, but also achieves remarkable progress on more challenging logographic languages like Chinese. To enhance image editing consistency, we introduce an improved multi-task training paradigm that incorporates not only traditional text-to-image (T2I) and text-image-to-image (TI2I) tasks but also image-to-image (I2I) reconstruction, effectively aligning the latent representations between Qwen2.5-VL and MMDiT. Furthermore, we separately feed the original image into Qwen2.5-VL and the VAE encoder to obtain semantic and reconstructive representations, respectively. This dual-encoding mechanism enables the editing module to strike a balance between preserving semantic consistency and maintaining visual fidelity. Qwen-Image achieves state-of-the-art performance, demonstrating its strong capabilities in both image generation and editing across multiple benchmarks.

cs.CV↗

arXiv2025

CovDocker: Benchmarking Covalent Drug Design with Tasks, Datasets, and Solutions

Molecular docking plays a crucial role in predicting the binding mode of ligands to target proteins, and covalent interactions, which involve the formation of a covalent bond between the ligand and the target, are particularly valuable due to their strong, enduring binding nature. However, most existing docking methods and deep learning approaches hardly account for the formation of covalent bonds and the associated structural changes. To address this gap, we introduce a comprehensive benchmark for covalent docking, CovDocker, which is designed to better capture the complexities of covalent binding. We decompose the covalent docking process into three main tasks: reactive location prediction, covalent reaction prediction, and covalent docking. By adapting state-of-the-art models, such as Uni-Mol and Chemformer, we establish baseline performances and demonstrate the effectiveness of the benchmark in accurately predicting interaction sites and modeling the molecular transformations involved in covalent binding. These results confirm the role of the benchmark as a rigorous framework for advancing research in covalent drug design. It underscores the potential of data-driven approaches to accelerate the discovery of selective covalent inhibitors and addresses critical challenges in therapeutic development.

q-bio.BM↗

arXiv2025

Nature Language Model: Deciphering the Language of Nature for Scientific Discovery

Foundation models have revolutionized natural language processing and artificial intelligence, significantly enhancing how machines comprehend and generate human languages. Inspired by the success of these foundation models, researchers have developed foundation models for individual scientific domains, including small molecules, materials, proteins, DNA, RNA and even cells. However, these models are typically trained in isolation, lacking the ability to integrate across different scientific domains. Recognizing that entities within these domains can all be represented as sequences, which together form the "language of nature", we introduce Nature Language Model (NatureLM), a sequence-based science foundation model designed for scientific discovery. Pre-trained with data from multiple scientific domains, NatureLM offers a unified, versatile model that enables various applications including: (i) generating and optimizing small molecules, proteins, RNA, and materials using text instructions; (ii) cross-domain generation/design, such as protein-to-molecule and protein-to-RNA generation; and (iii) top performance across different domains, matching or surpassing state-of-the-art specialist models. NatureLM offers a promising generalist approach for various scientific tasks, including drug discovery (hit generation/optimization, ADMET optimization, synthesis), novel material design, and the development of therapeutic proteins or nucleotides. We have developed NatureLM models in different sizes (1 billion, 8 billion, and 46.7 billion parameters) and observed a clear improvement in performance as the model size increases.

cs.AI↗

arXiv2025

3D-MolT5: Leveraging Discrete Structural Information for Molecule-Text Modeling

The integration of molecular and natural language representations has emerged as a focal point in molecular science, with recent advancements in Language Models (LMs) demonstrating significant potential for comprehensive modeling of both domains. However, existing approaches face notable limitations, particularly in their neglect of three-dimensional (3D) information, which is crucial for understanding molecular structures and functions. While some efforts have been made to incorporate 3D molecular information into LMs using external structure encoding modules, significant difficulties remain, such as insufficient interaction across modalities in pre-training and challenges in modality alignment. To address the limitations, we propose \textbf{3D-MolT5}, a unified framework designed to model molecule in both sequence and 3D structure spaces. The key innovation of our approach lies in mapping fine-grained 3D substructure representations into a specialized 3D token vocabulary. This methodology facilitates the seamless integration of sequence and structure representations in a tokenized format, enabling 3D-MolT5 to encode molecular sequences, molecular structures, and text sequences within a unified architecture. Leveraging this tokenized input strategy, we build a foundation model that unifies the sequence and structure data formats. We then conduct joint pre-training with multi-task objectives to enhance the model's comprehension of these diverse modalities within a shared representation space. Thus, our approach significantly improves cross-modal interaction and alignment, addressing key challenges in previous work. Further instruction tuning demonstrated that our 3D-MolT5 has strong generalization ability and surpasses existing methods with superior performance in multiple downstream tasks. Our code is available at https://github.com/QizhiPei/3D-MolT5.

q-bio.BM↗