arXiv subjects

Karin Verspoor

Publications and source records attributed to Karin Verspoor.

At least 37 records · Page 2Linked to original sources

arXiv2022

Improving negation detection with negation-focused pre-training

Negation is a common linguistic feature that is crucial in many language understanding tasks, yet it remains a hard problem due to diversity in its expression in different types of text. Recent work has shown that state-of-the-art NLP models underperform on samples containing negation in various tasks, and that negation detection models do not transfer well across domains. We propose a new negation-focused pre-training strategy, involving targeted data augmentation and negation masking, to better incorporate negation information into language models. Extensive experiments on common benchmarks show that our proposed approach improves negation detection performance and generalizability over the strong baseline NegBERT (Khandewal and Sawant, 2020).

cs.CL↗

arXiv2022

ITTC @ TREC 2021 Clinical Trials Track

This paper describes the submissions of the Natural Language Processing (NLP) team from the Australian Research Council Industrial Transformation Training Centre (ITTC) for Cognitive Computing in Medical Technologies to the TREC 2021 Clinical Trials Track. The task focuses on the problem of matching eligible clinical trials to topics constituting a summary of a patient's admission notes. We explore different ways of representing trials and topics using NLP techniques, and then use a common retrieval model to generate the ranked list of relevant trials for each topic. The results from all our submitted runs are well above the median scores for all topics, but there is still plenty of scope for improvement.

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arXiv2022

MPVNN: Mutated Pathway Visible Neural Network Architecture for Interpretable Prediction of Cancer-specific Survival Risk

Survival risk prediction using gene expression data is important in making treatment decisions in cancer. Standard neural network (NN) survival analysis models are black boxes with lack of interpretability. More interpretable visible neural network (VNN) architectures are designed using biological pathway knowledge. But they do not model how pathway structures can change for particular cancer types. We propose a novel Mutated Pathway VNN or MPVNN architecture, designed using prior signaling pathway knowledge and gene mutation data-based edge randomization simulating signal flow disruption. As a case study, we use the PI3K-Akt pathway and demonstrate overall improved cancer-specific survival risk prediction results of MPVNN over standard non-NN and other similar sized NN survival analysis methods. We show that trained MPVNN architecture interpretation, which points to smaller sets of genes connected by signal flow within the PI3K-Akt pathway that are important in risk prediction for particular cancer types, is reliable.

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arXiv2022

Assigning function to protein-protein interactions: a weakly supervised BioBERT based approach using PubMed abstracts

Motivation: Protein-protein interactions (PPI) are critical to the function of proteins in both normal and diseased cells, and many critical protein functions are mediated by interactions.Knowledge of the nature of these interactions is important for the construction of networks to analyse biological data. However, only a small percentage of PPIs captured in protein interaction databases have annotations of function available, e.g. only 4% of PPI are functionally annotated in the IntAct database. Here, we aim to label the function type of PPIs by extracting relationships described in PubMed abstracts. Method: We create a weakly supervised dataset from the IntAct PPI database containing interacting protein pairs with annotated function and associated abstracts from the PubMed database. We apply a state-of-the-art deep learning technique for biomedical natural language processing tasks, BioBERT, to build a model - dubbed PPI-BioBERT - for identifying the function of PPIs. In order to extract high quality PPI functions at large scale, we use an ensemble of PPI-BioBERT models to improve uncertainty estimation and apply an interaction type-specific threshold to counteract the effects of variations in the number of training samples per interaction type. Results: We scan 18 million PubMed abstracts to automatically identify 3253 new typed PPIs, including phosphorylation and acetylation interactions, with an overall precision of 46% (87% for acetylation) based on a human-reviewed sample. This work demonstrates that analysis of biomedical abstracts for PPI function extraction is a feasible approach to substantially increasing the number of interactions annotated with function captured in online databases.

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arXiv2022

Large-scale protein-protein post-translational modification extraction with distant supervision and confidence calibrated BioBERT

Protein-protein interactions (PPIs) are critical to normal cellular function and are related to many disease pathways. However, only 4% of PPIs are annotated with PTMs in biological knowledge databases such as IntAct, mainly performed through manual curation, which is neither time nor cost-effective. We use the IntAct PPI database to create a distant supervised dataset annotated with interacting protein pairs, their corresponding PTM type, and associated abstracts from the PubMed database. We train an ensemble of BioBERT models - dubbed PPI-BioBERT-x10 to improve confidence calibration. We extend the use of ensemble average confidence approach with confidence variation to counteract the effects of class imbalance to extract high confidence predictions. The PPI-BioBERT-x10 model evaluated on the test set resulted in a modest F1-micro 41.3 (P =5 8.1, R = 32.1). However, by combining high confidence and low variation to identify high quality predictions, tuning the predictions for precision, we retained 19% of the test predictions with 100% precision. We evaluated PPI-BioBERT-x10 on 18 million PubMed abstracts and extracted 1.6 million (546507 unique PTM-PPI triplets) PTM-PPI predictions, and filter ~ 5700 (4584 unique) high confidence predictions. Of the 5700, human evaluation on a small randomly sampled subset shows that the precision drops to 33.7% despite confidence calibration and highlights the challenges of generalisability beyond the test set even with confidence calibration. We circumvent the problem by only including predictions associated with multiple papers, improving the precision to 58.8%. In this work, we highlight the benefits and challenges of deep learning-based text mining in practice, and the need for increased emphasis on confidence calibration to facilitate human curation efforts.

cs.LG↗

arXiv2021

Impact of detecting clinical trial elements in exploration of COVID-19 literature

The COVID-19 pandemic has driven ever-greater demand for tools which enable efficient exploration of biomedical literature. Although semi-structured information resulting from concept recognition and detection of the defining elements of clinical trials (e.g. PICO criteria) has been commonly used to support literature search, the contributions of this abstraction remain poorly understood, especially in relation to text-based retrieval. In this study, we compare the results retrieved by a standard search engine with those filtered using clinically-relevant concepts and their relations. With analysis based on the annotations from the TREC-COVID shared task, we obtain quantitative as well as qualitative insights into characteristics of relational and concept-based literature exploration. Most importantly, we find that the relational concept selection filters the original retrieved collection in a way that decreases the proportion of unjudged documents and increases the precision, which means that the user is likely to be exposed to a larger number of relevant documents.

cs.CL↗

arXiv2021

Memorization vs. Generalization: Quantifying Data Leakage in NLP Performance Evaluation

Public datasets are often used to evaluate the efficacy and generalizability of state-of-the-art methods for many tasks in natural language processing (NLP). However, the presence of overlap between the train and test datasets can lead to inflated results, inadvertently evaluating the model's ability to memorize and interpreting it as the ability to generalize. In addition, such data sets may not provide an effective indicator of the performance of these methods in real world scenarios. We identify leakage of training data into test data on several publicly available datasets used to evaluate NLP tasks, including named entity recognition and relation extraction, and study them to assess the impact of that leakage on the model's ability to memorize versus generalize.

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arXiv2020

WikiUMLS: Aligning UMLS to Wikipedia via Cross-lingual Neural Ranking

We present our work on aligning the Unified Medical Language System (UMLS) to Wikipedia, to facilitate manual alignment of the two resources. We propose a cross-lingual neural reranking model to match a UMLS concept with a Wikipedia page, which achieves a recall@1 of 72%, a substantial improvement of 20% over word- and char-level BM25, enabling manual alignment with minimal effort. We release our resources, including ranked Wikipedia pages for 700k UMLS concepts, and WikiUMLS, a dataset for training and evaluation of alignment models between UMLS and Wikipedia. This will provide easier access to Wikipedia for health professionals, patients, and NLP systems, including in multilingual settings.

cs.CL↗

arXiv2020

COVID-SEE: Scientific Evidence Explorer for COVID-19 Related Research

We present COVID-SEE, a system for medical literature discovery based on the concept of information exploration, which builds on several distinct text analysis and natural language processing methods to structure and organise information in publications, and augments search by providing a visual overview supporting exploration of a collection to identify key articles of interest. We developed this system over COVID-19 literature to help medical professionals and researchers explore the literature evidence, and improve findability of relevant information. COVID-SEE is available at http://covid-see.com.

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arXiv2019

SemEval-2017 Task 3: Community Question Answering

We describe SemEval-2017 Task 3 on Community Question Answering. This year, we reran the four subtasks from SemEval-2016:(A) Question-Comment Similarity,(B) Question-Question Similarity,(C) Question-External Comment Similarity, and (D) Rerank the correct answers for a new question in Arabic, providing all the data from 2015 and 2016 for training, and fresh data for testing. Additionally, we added a new subtask E in order to enable experimentation with Multi-domain Question Duplicate Detection in a larger-scale scenario, using StackExchange subforums. A total of 23 teams participated in the task, and submitted a total of 85 runs (36 primary and 49 contrastive) for subtasks A-D. Unfortunately, no teams participated in subtask E. A variety of approaches and features were used by the participating systems to address the different subtasks. The best systems achieved an official score (MAP) of 88.43, 47.22, 15.46, and 61.16 in subtasks A, B, C, and D, respectively. These scores are better than the baselines, especially for subtasks A-C.

cs.CL↗

arXiv2019

Improving Chemical Named Entity Recognition in Patents with Contextualized Word Embeddings

Chemical patents are an important resource for chemical information. However, few chemical Named Entity Recognition (NER) systems have been evaluated on patent documents, due in part to their structural and linguistic complexity. In this paper, we explore the NER performance of a BiLSTM-CRF model utilising pre-trained word embeddings, character-level word representations and contextualized ELMo word representations for chemical patents. We compare word embeddings pre-trained on biomedical and chemical patent corpora. The effect of tokenizers optimized for the chemical domain on NER performance in chemical patents is also explored. The results on two patent corpora show that contextualized word representations generated from ELMo substantially improve chemical NER performance w.r.t. the current state-of-the-art. We also show that domain-specific resources such as word embeddings trained on chemical patents and chemical-specific tokenizers have a positive impact on NER performance.

cs.CL↗

arXiv2019

A bag-of-concepts model improves relation extraction in a narrow knowledge domain with limited data

This paper focuses on a traditional relation extraction task in the context of limited annotated data and a narrow knowledge domain. We explore this task with a clinical corpus consisting of 200 breast cancer follow-up treatment letters in which 16 distinct types of relations are annotated. We experiment with an approach to extracting typed relations called window-bounded co-occurrence (WBC), which uses an adjustable context window around entity mentions of a relevant type, and compare its performance with a more typical intra-sentential co-occurrence baseline. We further introduce a new bag-of-concepts (BoC) approach to feature engineering based on the state-of-the-art word embeddings and word synonyms. We demonstrate the competitiveness of BoC by comparing with methods of higher complexity, and explore its effectiveness on this small dataset.

cs.LG↗

arXiv2019

From POS tagging to dependency parsing for biomedical event extraction

Background: Given the importance of relation or event extraction from biomedical research publications to support knowledge capture and synthesis, and the strong dependency of approaches to this information extraction task on syntactic information, it is valuable to understand which approaches to syntactic processing of biomedical text have the highest performance. Results: We perform an empirical study comparing state-of-the-art traditional feature-based and neural network-based models for two core natural language processing tasks of part-of-speech (POS) tagging and dependency parsing on two benchmark biomedical corpora, GENIA and CRAFT. To the best of our knowledge, there is no recent work making such comparisons in the biomedical context; specifically no detailed analysis of neural models on this data is available. Experimental results show that in general, the neural models outperform the feature-based models on two benchmark biomedical corpora GENIA and CRAFT. We also perform a task-oriented evaluation to investigate the influences of these models in a downstream application on biomedical event extraction, and show that better intrinsic parsing performance does not always imply better extrinsic event extraction performance. Conclusion: We have presented a detailed empirical study comparing traditional feature-based and neural network-based models for POS tagging and dependency parsing in the biomedical context, and also investigated the influence of parser selection for a biomedical event extraction downstream task. Availability of data and material: We make the retrained models available at https://github.com/datquocnguyen/BioPosDep

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arXiv2018

End-to-end neural relation extraction using deep biaffine attention

We propose a neural network model for joint extraction of named entities and relations between them, without any hand-crafted features. The key contribution of our model is to extend a BiLSTM-CRF-based entity recognition model with a deep biaffine attention layer to model second-order interactions between latent features for relation classification, specifically attending to the role of an entity in a directional relationship. On the benchmark "relation and entity recognition" dataset CoNLL04, experimental results show that our model outperforms previous models, producing new state-of-the-art performances.

cs.CL↗

arXiv2018

Comparing CNN and LSTM character-level embeddings in BiLSTM-CRF models for chemical and disease named entity recognition

We compare the use of LSTM-based and CNN-based character-level word embeddings in BiLSTM-CRF models to approach chemical and disease named entity recognition (NER) tasks. Empirical results over the BioCreative V CDR corpus show that the use of either type of character-level word embeddings in conjunction with the BiLSTM-CRF models leads to comparable state-of-the-art performance. However, the models using CNN-based character-level word embeddings have a computational performance advantage, increasing training time over word-based models by 25% while the LSTM-based character-level word embeddings more than double the required training time.

cs.CL↗

arXiv2018

An improved neural network model for joint POS tagging and dependency parsing

We propose a novel neural network model for joint part-of-speech (POS) tagging and dependency parsing. Our model extends the well-known BIST graph-based dependency parser (Kiperwasser and Goldberg, 2016) by incorporating a BiLSTM-based tagging component to produce automatically predicted POS tags for the parser. On the benchmark English Penn treebank, our model obtains strong UAS and LAS scores at 94.51% and 92.87%, respectively, producing 1.5+% absolute improvements to the BIST graph-based parser, and also obtaining a state-of-the-art POS tagging accuracy at 97.97%. Furthermore, experimental results on parsing 61 "big" Universal Dependencies treebanks from raw texts show that our model outperforms the baseline UDPipe (Straka and Straková, 2017) with 0.8% higher average POS tagging score and 3.6% higher average LAS score. In addition, with our model, we also obtain state-of-the-art downstream task scores for biomedical event extraction and opinion analysis applications. Our code is available together with all pre-trained models at: https://github.com/datquocnguyen/jPTDP

cs.CL↗

arXiv2018

Convolutional neural networks for chemical-disease relation extraction are improved with character-based word embeddings

We investigate the incorporation of character-based word representations into a standard CNN-based relation extraction model. We experiment with two common neural architectures, CNN and LSTM, to learn word vector representations from character embeddings. Through a task on the BioCreative-V CDR corpus, extracting relationships between chemicals and diseases, we show that models exploiting the character-based word representations improve on models that do not use this information, obtaining state-of-the-art result relative to previous neural approaches.

cs.CL↗

arXiv2016

Analysing health professionals' learning interactions in online social networks: A social network analysis approach

Online Social Networking may be a way to support health professionals' need for continuous learning through interaction with peers and experts. Understanding and evaluating such learning is important but difficult, and Social Network Analysis (SNA) offers a solution. This paper demonstrates how SNA can be used to study levels of participation as well as the patterns of interactions that take place among health professionals in a large online professional learning network. Our analysis has shown that their learning network is highly centralised and loosely connected. The level of participation is low in general, and most interactions are structured around a small set of users consisting of moderators and core members. The structural patterns of interaction indicates there is a chance of small group learning occurring and requires further investigation to identify those potential learning groups. This first stage of analysis, to be followed by longitudinal study of the dynamics of interaction and complemented by content analysis of their discussion, may contribute to greater sophistication in the analysis and utilisation of new environments for health professional learning.

cs.SI↗