arXiv subjects

Karren Dai Yang

Publications and source records attributed to Karren Dai Yang.

3 recordsLinked to original sources

arXiv2026

Mechanisms of Multimodal Synchronization: Insights from Decoder-Based Video-Text-to-Speech Synthesis

Unified decoder-only transformers have shown promise for multimodal generation, yet the mechanisms by which they synchronize modalities with heterogeneous sampling rates remain underexplored. We investigate these mechanisms through video-text-to-speech (VTTS) synthesis-a controlled task requiring fine-grained temporal alignment between sparse text, video, and continuous speech. Using a unified decoder-only transformer, dubbed Visatronic, trained on VoxCeleb2, we study: (i) how modalities contribute complementary information, (ii) how positional encoding strategies enable synchronization across heterogeneous rates, (iii) how modality ordering shapes the trade-off between in-domain performance and cross-domain transfer, (iv) how phoneme-level synchronization metrics provide diagnostic insight into per-phoneme timing errors. Our findings reveal that both "global sequential indexing'' (unique position IDs across modalities) and "co-temporal ordered indexing'' (identical IDs for temporally corresponding tokens) achieve strong synchronization performance, with co-temporal ordered indexing providing a simple mechanism without explicit timestamp metadata. Both text and video contribute complementary signals: text ensures intelligibility while video provides temporal cues and emotional expressiveness. Modality ordering reveals a consistent trade-off: video-first ordering achieves stronger in-domain performance while text-first ordering generalizes more robustly to unseen domains. Our findings also reveal, that diverse large-scale training enables transferable synchronization strategies. To enable fine-grained analysis, we also introduce TimeSync, a phoneme-level metric that reveals temporal misalignments overlooked by frame-level metrics. These insights establish VTTS as a valuable testbed for understanding temporal synchronization in unified multimodal decoders.

cs.MM↗

arXiv2020

Causal Network Models of SARS-CoV-2 Expression and Aging to Identify Candidates for Drug Repurposing

Given the severity of the SARS-CoV-2 pandemic, a major challenge is to rapidly repurpose existing approved drugs for clinical interventions. While a number of data-driven and experimental approaches have been suggested in the context of drug repurposing, a platform that systematically integrates available transcriptomic, proteomic and structural data is missing. More importantly, given that SARS-CoV-2 pathogenicity is highly age-dependent, it is critical to integrate aging signatures into drug discovery platforms. We here take advantage of large-scale transcriptional drug screens combined with RNA-seq data of the lung epithelium with SARS-CoV-2 infection as well as the aging lung. To identify robust druggable protein targets, we propose a principled causal framework that makes use of multiple data modalities. Our analysis highlights the importance of serine/threonine and tyrosine kinases as potential targets that intersect the SARS-CoV-2 and aging pathways. By integrating transcriptomic, proteomic and structural data that is available for many diseases, our drug discovery platform is broadly applicable. Rigorous in vitro experiments as well as clinical trials are needed to validate the identified candidate drugs.

q-bio.MN↗

arXiv2017

Permutation-based Causal Inference Algorithms with Interventions

Learning directed acyclic graphs using both observational and interventional data is now a fundamentally important problem due to recent technological developments in genomics that generate such single-cell gene expression data at a very large scale. In order to utilize this data for learning gene regulatory networks, efficient and reliable causal inference algorithms are needed that can make use of both observational and interventional data. In this paper, we present two algorithms of this type and prove that both are consistent under the faithfulness assumption. These algorithms are interventional adaptations of the Greedy SP algorithm and are the first algorithms using both observational and interventional data with consistency guarantees. Moreover, these algorithms have the advantage that they are nonparametric, which makes them useful also for analyzing non-Gaussian data. In this paper, we present these two algorithms and their consistency guarantees, and we analyze their performance on simulated data, protein signaling data, and single-cell gene expression data.

stat.ME↗