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Karsten Kruse

Publications and source records attributed to Karsten Kruse.

At least 37 records · Page 2Linked to original sources

Localized states in active fluids

Biological active matter is typically tightly coupled to chemical reaction networks affecting its assembly-disassembly dynamics and stress generation. We show that localized states can emerge spontaneously if assembly of active matter is regulated by chemical species that are advected with flows resulting from gradients in the active stress. The mechanochemical localized patterns form via a subcritical bifurcation and for parameter values for which patterns do not exist in absence of the advective coupling. Our work identifies a generic mechanism underlying localized cellular patterns.

physics.bio-ph↗

Density-polarity coupling in confined active polar films: asters, spirals, and biphasic orientational phases

Topological defects in active polar fluids can organise spontaneous flows and influence macroscopic density patterns. Both of them play, for example, an important role during animal development. Yet the influence of density on active flows is poorly understood. Motivated by experiments on cell monolayers confined to discs, we study the coupling between density and polar order for a compressible active polar fluid in presence of a +1 topological defect. As in the experiments, we find a density-controlled spiral-to-aster transition. In addition, biphasic orientational phases emerge as a generic outcome of such coupling. Our results highlight the importance of density gradients as a potential mechanism for controlling flow and orientational patterns in biological systems.

cond-mat.soft↗

Phase separation on surfaces in presence of matter exchange

We present a field theory to describe the composition of a surface spontaneously exchanging matter with its bulk environment. By only assuming matter conservation in the system, we show with extensive numerical simulations that, depending on the matter exchange rates, a complex patterned composition distribution emerges in the surface. For one-dimensional systems we show analytically and numerically that coarsening is arrested and as a consequence domains have a characteristic length scale. Our results show that the causes of heterogeneous lipid composition in cellular membranes may be justified in simple physical terms.

physics.bio-ph↗

Final state observability estimates and cost-uniform approximate null-controllability for bi-continuous semigroups

We consider final state observability estimates for bi-continuous semigroups on Banach spaces, i.e. for every initial value, estimating the state at a final time $T>0$ by taking into account the orbit of the initial value under the semigroup for $t\in [0,T]$, measured in a suitable norm. We state a sufficient criterion based on an uncertainty relation and a dissipation estimate and provide two examples of bi-continuous semigroups which share a final state observability estimate, namely the Gauss-Weierstrass semigroup and the Ornstein-Uhlenbeck semigroup on the space of bounded continuous functions. Moreover, we generalise the duality between cost-uniform approximate null-controllability and final state observability estimates to the setting of locally convex spaces for the case of bounded and continuous control functions, which seems to be new even for the Banach spaces case.

math.OC↗

Exponential single server queues in an interactive random environment

We consider exponential single server queues with state-dependent arrival and service rates which evolve under influences of external environments. The transitions of the queues are influenced by the environment's state and the movements of the environment depend on the status of the queues (bi-directional interaction). The environment is constructed in a way to encompass various models from the recent Operations Research literature, where a queue is coupled with an inventory or with reliability issues. With a Markovian joint queueing-environment process we prove separability for a large class of such interactive systems, i.e. the steady state distribution is of product form and explicitly given. The queue and the environment processes decouple asymptotically and in steady state. For non-separable systems we develop ergodicity and exponential ergodicity criteria via Lyapunov functions. By examples we explain principles for bounding departure rates of served customers (throughputs) of non-separable systems by throughputs of related separable systems as upper and lower bound.

math.PR↗

On vector-valued functions and the $\varepsilon$-product

This habilitation thesis centres on linearisation of vector-valued functions which means that vector-valued functions are represented by continuous linear operators. The first question we face is which vector-valued functions may be represented by continuous linear operators where vector-valued means that the functions have values in a locally convex Hausdorff space $E$. We study this problem in the framework of $\varepsilon$-products and give sufficient conditions when a space of $E$-valued functions coincides (up to an isomorphism) with the $\varepsilon$-product of a corresponding space of scalar-valued functions and the codomain $E$. We apply our linearisation results to lift results that are known for the scalar-valued case to the vector-valued case. We transfer the solvability of a linear partial differential equation in certain function spaces from the scalar-valued case to the vector-valued case, which also gives an affirmative answer to the question of (continuous, smooth, holomorphic, distributional, etc.) parameter dependence of solutions in the scalar-valued case. Further, we give a unified approach to handle the problem of extending vector-valued functions via the existence of weak extensions under the constraint of preserving the properties, like holomorphy, of the scalar-valued extensions. Our approach also covers weak-strong principles. In particular, we study weak-strong principles for continuously partially differentiable functions of finite order and improve the well-known weak-strong principles of Grothendieck and Schwartz. We use our results to derive Blaschke's convergence theorem for several spaces of vector-valued functions and Wolff's theorem for the description of dual spaces of several function spaces of scalar-valued functions. Moreover, we transfer known series expansions and sequence space representations from scalar-valued to vector-valued functions.

math.FA↗

Extension of vector-valued functions and weak-strong principles for differentiable functions of finite order

In this paper we study the problem of extending functions with values in a locally convex Hausdorff space $E$ over a field $\mathbb{K}$, which have weak extensions in a weighted Banach space $\mathcal{F}ν(Ω,\mathbb{K})$ of scalar-valued functions on a set $Ω$, to functions in a vector-valued counterpart $\mathcal{F}ν(Ω,E)$ of $\mathcal{F}ν(Ω,\mathbb{K})$. Our findings rely on a description of vector-valued functions as linear continuous operators and extend results of Frerick, Jordá and Wengenroth. As an application we derive weak-strong principles for continuously partially differentiable functions of finite order, vector-valued versions of Blaschke's convergence theorem for several spaces and Wolff type descriptions of dual spaces.

math.FA↗

A note on the Lumer--Phillips theorem for bi-continuous semigroups

Given a Banach space $X$ and an additional coarser Hausdorff locally convex topology $τ$ on $X$ we characterise the generators of $τ$-bi-continuous semigroups in the spirit of the Lumer--Phillips theorem, i.e. by means of dissipativity w.r.t.~a directed system of seminorms and a range condition.

math.FA↗

The abstract Cauchy problem in locally convex spaces

We derive sufficient criteria for the uniqueness and existence of solutions of the abstract Cauchy problem in locally convex Hausdorff spaces. Our approach is based on a suitable notion of an asymptotic Laplace transform and extends results of Langenbruch beyond the class of Fréchet spaces.

math.FA↗

Selection for size in molecular self-assembly drives the de novo evolution of a molecular machine

The functioning of machines typically requires a concerted action of their parts. This requirement also holds for molecular motors that drive vital cellular processes and imposes constraints on their conformational changes as well as the rates at which they occur. It remains unclear whether features required for functional molecular machines can emerge simultaneously or require sequential adaptation to different selection pressures during evolution. We address this question by theoretically analyzing the evolution of filament treadmilling. This process refers to the self-assembly of linear polymers that grow and shrink at equal rates at their opposite ends. It constitutes a simple biological molecular machine that is notably involved in bacterial cell division and requires that several conditions are met. In our simulation framework, treadmilling emerges as a consequence of selecting for a target average polymer length. We discuss, why other forms of assembly dynamics, which also reach the imposed target length, do not evolve in our simulations. Our work shows that complex molecular functions can evolve de novo under selection for a single physical feature.

physics.bio-ph↗

On equicontinuity and tightness of bi-continuous semigroups

In contrast to classical strongly continuous semigroups, the study of bi-continuous semigroups comes with some freedom in the properties of the associated locally convex topology. This paper aims to give minimal assumptions in order to recover typical features like tightness and equicontinuity with respect to the mixed topology as well as to carefully clarify on mutual relations between previously studied variants of these notions. The abstract results -- exploiting techniques from topological vector spaces -- are thoroughly discussed by means of several example classes, such as semigroups on spaces of bounded continuous functions.

math.FA↗

Extension of vector-valued functions and sequence space representation

We give a unified approach to handle the problem of extending functions with values in a locally convex Hausdorff space $E$ over a field $\mathbb{K}$, which have weak extensions in a space $\mathcal{F}(Ω,\mathbb{K})$ of scalar-valued functions on a set $Ω$, to functions in a vector-valued counterpart $\mathcal{F}(Ω,E)$ of $\mathcal{F}(Ω,\mathbb{K})$. The results obtained base upon a representation of vector-valued functions as linear continuous operators and extend results of Bonet, Frerick, Gramsch and Jordá. In particular, we apply them to obtain a sequence space representation of $\mathcal{F}(Ω,E)$ from a known representation of $\mathcal{F}(Ω,\mathbb{K})$.

math.FA↗

Surjectivity of the $\overline{\partial}$-operator between weighted spaces of smooth vector-valued functions

We derive sufficient conditions for the surjectivity of the Cauchy-Riemann operator $\overline{\partial}$ between spaces of weighted smooth Fréchet-valued functions. This is done by establishing an analog of Hörmander's theorem on the solvability of the inhomogeneous Cauchy-Riemann equation in a space of smooth $\mathbb{C}$-valued functions whose topologyis given by a whole family of weights. Our proof relies on a weakened variant of weak reducibility of the corresponding subspace of holomorphic functions in combination with the Mittag-Leffler procedure. Using tensor products, we deduce the corresponding result on the solvability of the inhomogeneous Cauchy-Riemann equation for Fréchet-valued functions.

math.FA↗

Asymptotic Fourier and Laplace transforms for vector-valued hyperfunctions

We study Fourier and Laplace transforms for Fourier hyperfunctions with values in a complex locally convex Hausdorff space. Since any hyperfunction with values in a wide class of locally convex Hausdorff spaces can be extended to a Fourier hyperfunction, this gives simple notions of asymptotic Fourier and Laplace transforms for vector-valued hyperfunctions, which improves the existing models of Komatsu, Bäumer, Lumer and Neubrander and Langenbruch.

math.FA↗

The inhomogeneous Cauchy-Riemann equation for weighted smooth vector-valued functions on strips with holes

This paper is dedicated to the question of surjectivity of the Cauchy-Riemann operator on spaces $\mathcal{EV}(Ω,E)$ of $\mathcal{C}^{\infty}$-smooth vector-valued functions whose growth on strips along the real axis with holes $K$ is induced by a family of continuous weights $\mathcal{V}$. Vector-valued means that these functions have values in a locally convex Hausdorff space $E$ over $\mathbb{C}$. We characterise the weights $\mathcal{V}$ which give a counterpart of the Grothendieck-Köthe-Silva duality $\mathcal{O}(\mathbb{C}\setminus K)/\mathcal{O}(\mathbb{C})\cong\mathscr{A}(K)$ with non-empty compact $K\subset\mathbb{R}$ for weighted holomorphic functions. We use this duality to prove that the kernel $\operatorname{ker}\overline{\partial}$ of the Cauchy-Riemann operator $\overline{\partial}$ in $\mathcal{EV}(Ω):=\mathcal{EV}(Ω,\mathbb{C})$ has the property $(Ω)$ of Vogt. Then an application of the splitting theory of Vogt for Fréchet spaces and of Bonet and Domański for (PLS)-spaces in combination with some previous results on the surjectivity of the Cauchy-Riemann operator $\overline{\partial}\colon\mathcal{EV}(Ω)\to\mathcal{EV}(Ω)$ yields the surjectivity of the Cauchy-Riemann operator on $\mathcal{EV}(Ω,E)$ if $E:=F_{b}'$ with some Fréchet space $F$ satisfying the condition $(DN)$ or if $E$ is an ultrabornological (PLS)-space having the property $(PA)$. This solves the smooth (holomorphic, distributional) parameter dependence problem for the Cauchy-Riemann operator on $\mathcal{EV}(Ω)$.

math.FA↗

Subordination for sequentially equicontinuous equibounded $C_0$-semigroups

We consider operators $A$ on a sequentially complete Hausdorff locally convex space $X$ such that $-A$ generates a (sequentially) equicontinuous equibounded $C_0$-semigroup. For every Bernstein function $f$ we show that $-f(A)$ generates a semigroup which is of the same `kind' as the one generated by $-A$. As a special case we obtain that fractional powers $-A^α$, where $α\in (0,1)$, are generators.

math.FA↗

Properties of twisted topological defects in 2D nematic liquid crystals

Topological defects are one of the most conspicuous features of liquid crystals. In two dimensional nematics, they have been shown to behave effectively as particles with both, charge and orientation, which dictate their interactions. Here, we study "twisted" defects that have a radially dependent orientation. We find that twist can be partially relaxed through the creation and annihilation of defect pairs. By solving the equations for defect motion and calculating the forces on defects, we identify four distinct elements that govern the relative relaxational motion of interacting topological defects, namely attraction, repulsion, co-rotation and co-translation. The interaction of these effects can lead to intricate defect trajectories, which can be controlled by setting relevant timescales.

cond-mat.soft↗

Excitable actin dynamics and amoeboid cell migration

Amoeboid cell migration is characterized by frequent changes of the direction of motion and resembles a persistent random walk on long time scales. Although it is well known that cell migration is typically driven by the actin cytoskeleton, the cause of this migratory behavior remains poorly understood. We analyze the spontaneous dynamics of actin assembly due to nucleation promoting factors, where actin filaments lead to an inactivation of the nucleators. We show that this system exhibits excitable dynamics and can spontaneously generate waves, which we analyse in detail. By using a phase-field approach, we show that these waves can generate cellular random walks. We explore how the characteristics of these persistent random walks depend on the parameters governing the actin-nucleator dynamics. In particular, we find that the effective diffusion constant and the persistence time depend strongly on the speed of filament assembly and the rate of nucleator inactivation. Our findings point to a deterministic origin of the random walk behavior and suggest that cells could adapt their migration pattern by modifying the pool of available actin.

physics.bio-ph↗