arXiv subjects

Katarzyna

Publications and source records attributed to Katarzyna.

2 recordsLinked to original sources

arXiv2023

The known unknowns of the Hsp90 chaperone

Molecular chaperones are vital proteins that maintain protein homeostasis by assisting in protein folding, activation, degradation, and stress protection. Among them, heat-shock protein 90 (Hsp90) stands out as an essential proteostasis hub in eukaryotes, chaperoning hundreds of "clients" (substrates). After decades of research, several "known unknowns" about the molecular function of Hsp90 remain unanswered, hampering rational drug design for the treatment of cancers, neurodegenerative and other diseases. We highlight three fundamental open questions, reviewing the current state of the field for each, and discuss new opportunities, including single-molecule technologies, to answer the known unknowns of the Hsp90 chaperone.

q-bio.BM↗

arXiv2013

Symmetrically complete ordered sets, abelian groups and fields

We characterize and construct linearly ordered sets, abelian groups and fields that are {\emph symmetrically complete}, meaning that the intersection over any chain of closed bounded intervals is nonempty. Such ordered abelian groups and fields are important because generalizations of Banach's Fixed Point Theorem hold in them. We prove that symmetrically complete ordered abelian groups and fields are divisible Hahn products and real closed power series fields, respectively. We show how to extend any given ordered set, abelian group or field to one that is symmetrically complete. A main part of the paper establishes a detailed study of the cofinalities in cuts.

math.LO↗