Kathan Pandya | Searcharxiv

arXiv2025

BioDisco: Multi-agent hypothesis generation with dual-mode evidence, iterative feedback and temporal evaluation

Identifying novel hypotheses is essential to scientific research, yet this process risks being overwhelmed by the sheer volume and complexity of available information. Existing automated methods often struggle to generate novel and evidence-grounded hypotheses, lack robust iterative refinement and rarely undergo rigorous temporal evaluation for future discovery potential. To address this, we propose BioDisco, a multi-agent framework that draws upon language model-based reasoning and a dual-mode evidence system (biomedical knowledge graphs and automated literature retrieval) for grounded novelty, integrates an internal scoring and feedback loop for iterative refinement, and validates performance through pioneering temporal and human evaluations and a Bradley-Terry paired comparison model to provide statistically-grounded assessment. Our evaluations demonstrate superior novelty and significance over ablated configurations and generalist biomedical agents. Designed for flexibility and modularity, BioDisco allows seamless integration of custom language models or knowledge graphs, and can be run with just a few lines of code.

cs.AI↗

arXiv2025

CleanSurvival: Automated data preprocessing for time-to-event models using reinforcement learning

Data preprocessing is often paid little attention in machine learning, despite its potentially significant impact on model performance. While automated machine learning pipelines are starting to recognise and integrate data preprocessing into their solutions for classification and regression tasks, this integration is lacking for more specialised tasks like time-to-event models for censored data. As a result, survival analysis not only faces the general challenges of data preprocessing but also suffers from the lack of tailored, automated solutions in this area. To address this gap, this paper presents CleanSurvival, a reinforcement-learning-based solution for optimizing preprocessing pipelines, extended specifically for survival analysis. The framework can handle continuous and categorical variables. It builds upon Learn2Clean's Q-learning to select which combination of data imputation, outlier detection and feature extraction techniques achieves optimal performance for a Cox, random forest, neural network or user-supplied time-to-event model. Experimental benchmarks on real-world datasets show that the Q-learning-based data preprocessing can improve predictive performance relative to simple baselines, while runtime behaviour is condition-dependent and most clearly interpretable in the best-covered benchmark cells. Furthermore, a simulation study demonstrates effectiveness across different types and levels of missingness and noise. With an increase in the use of machine learning, it becomes important to generalise AutoML pipelines to a variety of models now present, including survival analysis. Tools like CleanSurvival, which integrate preprocessing for survival analysis, can make survival studies faster and easier to perform, while also yielding more robust results.

cs.LG↗