Katrin Philipp | Searcharxiv

arXiv2018

Diffraction-limited axial scanning in thick biological tissue employing an aberration correcting adaptive lens

Diffraction-limited focusing deep into biological tissue is challenging due to spherical aberrations that lead to a broadening of the focal spot particularly in axial direction. While the diffraction-limit can be restored employing aberration correction with a deformable mirror or spatial light modulator, a bulky optical setup results due to the required beam-folding. We propose a bi actor adaptive lens, that enables axial scanning and at the same time correction of specimen induced spherical aberrations while offering a compact setup. Using the bi-actor lens in a confocal microscope, we show diffraction limited axial scanning up to \SI{340}{\micro m} deep inside a phantom specimen. Applying this technique for in-vivo measurements of zebrafish embryos with reporter gene-driven fluorescence in the thyroid gland reveals substructures of thyroid follicles.

physics.optics↗

arXiv2018

Multiphysics simulation of the aspherical deformation of piezo-glass membrane lenses including hysteresis, fabrication and non-linear effects

In this paper we present and verify the non-linear simulation of an aspherical adaptive lens based on a piezo-glass sandwich membrane with combined bending and buckling actuation. To predict the full non-linear piezoelectric behavior, we measured the non-linear charge coefficient, hysteresis and creep effects of the piezo material and inserted them into the FEM model using a virtual electric field. We further included and discussed the fabrication parameters -- glue layers and thermal stress -- and their variations. To verify our simulations, we fabricated and measured a set of lenses with different geometries, where we found good agreement and show that their qualitative behavior is also well described by a simple analytical model. We finally discuss the effects of the geometry on the electric response and find, e.g., an increased focal power range from $\pm 4.5$ to $\pm 9\, \mathrm{m}^{-1}$ when changing the aperture from $14$ to $10\, \mathrm{mm}$.

physics.app-ph↗