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Keenan M. L. Mack

Publications and source records attributed to Keenan M. L. Mack.

2 recordsLinked to original sources

Degree-correlation, robustness, and vulnerability in finite scale-free networks

Many naturally occurring networks have a power-law degree distribution as well as a non-zero degree correlation. Despite this, most studies analyzing the robustness to random node-deletion and vulnerability to targeted node-deletion have concentrated only on power-law degree distribution and ignored degree correlation. This study looks specifically at the effect degree-correlation has on robustness and vulnerability in scale-free networks. Our results confirm Newman's finding that positive degree-correlation increases robustness and decreases vulnerability. However, we found that networks with positive degree-correlation are more vulnerable to random node-deletion than to targeted deletion methods that utilize knowledge of initial node-degree only. Targeted deletion sufficiently alters the topology of the network to render this method less effective than uniform random methods unless changes in topology are accounted for. This result indicates the importance of degree correlation in certain network applications.

physics.soc-ph↗

Spatial population expansion promotes the evolution of cooperation in an experimental Prisoner's Dilemma

Cooperation is ubiquitous in nature, but explaining its existence remains a central interdisciplinary challenge. Cooperation is most difficult to explain in the Prisoner's Dilemma game, where cooperators always lose in direct competition with defectors despite increasing mean fitness. Here we demonstrate how spatial population expansion, a widespread natural phenomenon, promotes the evolution of cooperation. We engineer an experimental Prisoner's Dilemma game in the budding yeast Saccharomyces cerevisiae to show that, despite losing to defectors in nonexpanding conditions, cooperators increase in frequency in spatially expanding populations. Fluorescently labeled colonies show genetic demixing of cooperators and defectors, followed by increase in cooperator frequency as cooperator sectors overtake neighboring defector sectors. Together with lattice-based spatial simulations, our results suggest that spatial population expansion drives the evolution of cooperation by (1) increasing positive genetic assortment at population frontiers and (2) selecting for phenotypes maximizing local deme productivity. Spatial expansion thus creates a selective force whereby cooperator-enriched demes overtake neighboring defector-enriched demes in a "survival of the fastest". We conclude that colony growth alone can promote cooperation and prevent defection in microbes. Our results extend to other species with spatially restricted dispersal undergoing range expansion, including pathogens, invasive species, and humans.

q-bio.PE↗