arXiv subjects

Kenneth Heitritter

Publications and source records attributed to Kenneth Heitritter.

4 recordsLinked to original sources

arXiv2024

Quantum Resources Required for Binding Affinity Calculations of Amyloid beta

Amyloid beta, an intrinsically disordered protein, plays a seemingly important but not well-understood role in neurodegenerative diseases like Alzheimer's disease. A key feature of amyloid beta, which could lead to potential therapeutic intervention pathways, is its binding affinity to certain metal centers, like iron and copper. Numerically calculating such binding affinities is a computationally challenging task, involving strongly correlated metal centers. A key bottleneck in understanding the binding affinity is obtaining estimates of the ground state energy. Quantum computers have the potential to accelerate such calculations but it is important to understand the quantum resources required. In this work, we detail a computational workflow for binding affinity calculations for amyloid beta utilizing quantum algorithms, providing estimated quantum resources required, at both the logical and hardware level.

quant-ph↗

arXiv2022

Prolegomena to a hybrid classical/Rydberg simulator for hadronization (QuPyth)

Programmable neutral-atom arrays provide a promising route to real-time analog simulation of strongly interacting quantum systems. We introduce a two leg Rydberg atom ladder that realizes string dynamics and controllable particle production using experimentally accessible parameters. A mapping between local Rydberg occupations and an emergent electric field yields charge anticharge pairs connected by dynamical strings. Classical simulations enforcing Rydberg blockade constraints identify regimes with suppressed entanglement spreading and tunable particle multiplicities, which are seen to be signatures of confinement and string breaking. Particle multiplicities typically grow monotonically with time and system size and depend sensitively on simulator detuning and interaction scales. These results establish the ladder geometry as a viable near-term analog quantum simulator of string fragmentation, and motivate hybrid workflows in which quantum devices contribute nonperturbative real-time dynamics to event generation.

quant-ph↗

arXiv2020

General structure of Thomas$-$Whitehead gravity

Thomas-Whitehead (TW) gravity is a projectively invariant model of gravity over a d-dimensional manifold that is intimately related to string theory through reparameterization invariance. Unparameterized geodesics are the ubiquitous structure that ties together string theory and higher dimensional gravitation. This is realized through the projective geometry of Tracy Thomas. The projective connection, due to Thomas and later Whitehead, admits a component that in one dimension is in one-to-one correspondence with the coadjoint elements of the Virasoro algebra. This component is called the diffeomorphism field $\mathcal{D}_{ab }$ in the literature. It also has been shown that in four dimensions, the TW\ action collapses to the Einstein-Hilbert action with cosmological constant when $\mathcal{D}_{ab}$ is proportional to the Einstein metric. These previous results have been restricted to either particular metrics, such as the Polyakov 2D\ metric, or were restricted to coordinates that were volume preserving. In this paper, we review TW gravity and derive the gauge invariant TW action that is explicitly projectively invariant and general coordinate invariant. We derive the covariant field equations for the TW action and show how fermionic fields couple to the gauge invariant theory. The independent fields are the metric tensor $g_{ab}$, the fundamental projective invariant $\Pi^{a}_{\,\,\,bc}$, and the diffeomorphism field $\mathcal D_{ab}$.

hep-th↗

arXiv2019

Dark Energy From Dynamical Projective Connections

We further develop the gravitational model, Thomas-Whitehead Gravity (TW Gravity), that arises when projective connections become dynamical fields. TW Gravity has its origins in geometric actions from string theory where the TW projective connection appears as a rank two tensor, $\mathcal{D}_{ab}$, on the spacetime manifold. Using a Gauss-Bonnet (GB) action built from the $(\mathrm{d}+1)$-dimensional TW connection, and applying the tensor decomposition $\mathcal{D}_{ab} = D_{ab} + 4\Lambda /(\mathrm{d}(\mathrm{d}-1)) g_{ab}$, we arrive at a gravitational model made up of a $\mathrm{d}$-dimensional Einstein-Hilbert + GB action sourced by $D_{ab}$ and with cosmological constant $\Lambda$. The $\mathrm{d}=4$ action is studied and we find that $\Lambda \propto 1/J_0$, with $J_0$ the coupling constant for $D_{ab}$. For $\Lambda$ equal to the current measured value, $J_0$ is on the order of the measured angular momentum of the observable Universe. We view this as $\Lambda$ controlling the scale of patches of the Universe that acquire angular momentum, with the net angular momentum of multiple patches vanishing, as required by the cosmological principle. We further find a universal axial scalar coupling to all fermions where the trace, $\mathcal{D} = \mathcal{D}_{ab}g^{ab}$ acts as the scalar. This suggests that $\mathcal{D}$ is also a dark matter portal for non-standard model fermions.

hep-th↗