SearcharxivSearch

arXiv subjects

Kenneth Martin Rice

Publications and source records attributed to Kenneth Martin Rice.

2 recordsLinked to original sources

A Bayesian 'sandwich' for variance estimation

Large-sample Bayesian analogs exist for many frequentist methods, but are less well-known for the widely-used 'sandwich' or 'robust' variance estimates. We review existing approaches to Bayesian analogs of sandwich variance estimates and propose a new analog, as the Bayes rule under a form of balanced loss function, that combines elements of standard parametric inference with fidelity of the data to the model. Our development is general, for essentially any regression setting with independent outcomes. Being the large-sample equivalent of its frequentist counterpart, we show by simulation that Bayesian robust standard error estimates can faithfully quantify the variability of parameter estimates even under model misspecification -- thus retaining the major attraction of the original frequentist version. We demonstrate our Bayesian analog of standard error estimates when studying the association between age and systolic blood pressure in NHANES.

stat.ME

Fast permutation tests and related methods, for association between rare variants and binary outcomes

In large scale genetic association studies, a primary aim is to test for association between genetic variants and a disease outcome. The variants of interest are often rare, and appear with low frequency among subjects. In this situation, statistical tests based on standard asymptotic results do not adequately control the Type I error rate, especially if the case:control ratio is unbalanced. In this paper, we propose the use of permutation and approximate unconditional tests for testing association with rare variants. We use novel analytical calculations to efficiently approximate the true Type I error rate under common study designs, and in numerical studies show that the proposed classes of tests significantly improve upon standard testing methods. We also illustrate our methods in data from a recent case-control study, for genetic causes of a severe side-effect of a common drug treatment.

stat.ME