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Kerstin Schirrmann

Publications and source records attributed to Kerstin Schirrmann.

3 recordsLinked to original sources

Compaction in a deformable porous cylinder with elastic boundaries

Perfusion of soft materials such as biological tissue or hydrogels is essential for the functioning of organ and laboratory systems such as chromatographic columns and bioreactors. Inspired by these applications, we model fluid-driven compaction in a long, thin cylindrical porous medium bounded by an impermeable elastic membrane and study how flow regimes relate to elastic parameters. Using a Lagrangian formulation of Darcy flow coupled to small-strain linear elasticity with porosity dependent permeability and elastic moduli, we perform an asymptotic reduction in the small aspect ratio limit and obtain a leading-order nonlinear diffusion equation for the porosity, which we solve numerically. Whereas rigid boundaries produce a compaction plateau, compliant walls exhibit, at most, an intermediate plateau beyond which the flow increases once the imposed pressure becomes comparable to the product of membrane stiffness and initial porosity. When the membrane is less stiff than the porous medium, flow rate can exceed that expected for a rigid medium. A parameter space map distinguishes regimes where plateau and breakthrough occur, where the steady flow rate is below (sub-Darcy) or above (super-Darcy) the undeformable-medium prediction, and delineates the small-strain domain in which the theory applies. An asymptotic solution for negligible gravity captures the departure from the plateau and yields compact expressions for effective permeability and flow rate.

physics.flu-dyn↗

Robust fabrication of ultra-soft tunable PDMS microcapsules as a biomimetic model for red blood cells

Microcapsules with liquid cores encapsulated by thin membranes have many applications in science, medicine and industry. In this paper, we design a suspension of microcapsules which flow and deform like red blood cells (RBCs), as a valuable tool to investigate microhaemodynamics. A reconfigurable and easy-to-assemble 3D nested glass capillary device is used to robustly fabricate water-oil-water double emulsions which are then converted into spherical microcapsules with hyperelastic membranes by cross-linking the polydimethylsiloxane (PDMS) layer coating the droplets. The resulting capsules are monodisperse to within 1% and can be made in a wide range of size and membrane thickness. We use osmosis to deflate by 36% initially spherical capsules of diameter 350 μm and a membrane thickness of 4% of their radius, in order to match the reduced volume of biconcave RBCs. We compare the propagation of initially spherical and deflated capsules under constant volumetric flow in cylindrical capillaries of different confinements. We find that only deflated capsules deform broadly similarly to RBCs over a similar range of capillary numbers (Ca) -- the ratio of viscous to elastic forces. Similarly to the RBCs, the microcapsules transition from a symmetric 'parachute' to an asymmetric 'slipper'-like shape as Ca increases within the physiological range, demonstrating intriguing confinement-dependent dynamics. In addition to biomimetic RBC properties, high-throughput fabrication of tunable ultra-soft microcapsules could be further functionalized and find applications in other areas of science and engineering

cond-mat.soft↗

Self-assembly of coated microdroplets at the sudden expansion of a microchannel

We report observations of the self-assembly of coated droplets into regular clusters at the sudden expansion of a microfluidic channel. A double emulsion consisting of a regular train of coated microdroplets was created upstream of the channel expansion, so that the inter-drop distance, droplet length, velocity and coating thickness could be varied by imposing different inlet pressures, albeit not independently. Provided that the enlarged channel remains sufficiently confined to prohibit propagation in double file, droplets can assemble sequentially into regular linear clusters at the expansion. Droplets join a cluster via the coalescence of their coating film with that of the group ahead. This coalescence occurs when the droplets approach each other to within a critical distance at the expansion, enabled by hydrodynamic interactions within the train. Clusters comprising a finite number of droplets are obtained because reconfiguration of the droplet assembly during coalescence increases the distance to the following droplet. Decreasing the inter-drop distance increases the cluster size up to a maximum value beyond which continuous clusters form. Formalising these observations in a simple model reveals that clusters of any size are possible but that they occur for increasingly narrow ranges of parameter values. Our experimental observations suggests that background experimental fluctuations limit the maximum discrete cluster size in practice. This method of self-assembly offers a robust alternative to flow focusing for encapsulating multiple cores in a single coating film and the potential to build more complex colloidal building blocks by de-confining the clusters.

cond-mat.soft↗