SearcharxivSearch

arXiv subjects

Kerui Peng

Publications and source records attributed to Kerui Peng.

2 recordsLinked to original sources

Semantic Flow Regularization: Teaching LLMs to Generate Diverse Yet Coherent Responses

When large language models are fine-tuned to generate persona- or tone-conditioned responses, their output diversity is severely limited--a failure we term Cross-Style Collapse. We trace this collapse to the cross-entropy objective, which under shared representations tends to suppress diverse continuations. We propose Semantic Flow Regularization (SFR), a lightweight auxiliary objective that supervises the backbone with continuous sentence-encoder embeddings of future segments via conditional flow matching. The stochastic flow source preserves multi-modality by construction; the flow-matching head is discarded at inference, adding zero deployment cost. On a large-scale industrial dialogue dataset (Qwen3-32B, 9 personas), SFR improves output diversity, style fidelity, and response quality over SFT. We further validate on the public LiveCodeBench-v5 (Qwen2.5-Coder-7B-Instruct), where SFR consistently improves pass@k, confirming generality beyond stylized dialogue. A controlled comparison on MBPP reveals Multi-Token Prediction to be a degenerate special case of SFR.

cs.CL

Diversity in immunogenomics: the value and the challenge

With the advent of high-throughput sequencing technologies, the fields of immunogenomics and adaptive immune receptor repertoire research are facing both opportunities and challenges. Adaptive immune receptor repertoire sequencing (AIRR-seq) has become an increasingly important tool to characterize T and B cell responses in settings of interest. However, the majority of AIRR-seq studies conducted so far were performed in individuals of European ancestry, restricting the ability to identify variation in human adaptive immune responses across populations and limiting their applications. As AIRR-seq studies depend on the ability to assign VDJ sequence reads to the correct germline gene segments, efforts to characterize the genomic loci that encode adaptive immune receptor genes in different populations are urgently needed. The availability of comprehensive germline gene databases and further applications of AIRR-seq studies to individuals of non-European ancestry will substantially enhance our understanding of human adaptive immune responses, promote the development of effective diagnostics and treatments, and eventually advance precision medicine.

q-bio.GN