SearcharxivSearch

arXiv subjects

Kevin S. Xu

Publications and source records attributed to Kevin S. Xu.

At least 19 recordsLinked to original sources

Paired Recipient-based Evaluation of Survival Prediction for Deceased Donor Kidney Transplants

There has been significant interest in using machine learning algorithms to predict kidney transplant outcomes, such as the number of years until a graft inevitably fails. These prediction algorithms could possibly be used for pre-transplant donor-recipient matching to identify more compatible donors and recipients and thus improve post-transplant outcomes. In this study, we explore the use of survival prediction models trained on deceased donor kidney transplant data from the Scientific Registry of Transplant Recipients (SRTR). We propose a novel paired recipient-based evaluation framework that compares graft outcomes between two recipients who received kidneys from the same deceased donor, allowing us to evaluate the counterfactual benefit of changing the recipient for a certain donor. We find that five different survival prediction models, ranging in complexity from linear to deep learning-based models, all result in ~60% paired recipient-based accuracy. We further translate this accuracy into an interpretable quantity of post-transplant years gained. We also highlight major limitations of the commonly used concordance index (C-index) metric for evaluating survival prediction accuracy in this setting and demonstrate that our proposed paired recipient-based accuracy metric is more clinically relevant and better reflects real-world allocation settings.

cs.LG

LIT-LVM: Structured Regularization for Interaction Terms in Linear Predictors using Latent Variable Models

Some of the simplest, yet most frequently used predictors in statistics and machine learning use weighted linear combinations of features. Such linear predictors can model non-linear relationships between features by adding interaction terms corresponding to the products of all pairs of features. We consider the problem of accurately estimating coefficients for interaction terms in linear predictors. We hypothesize that the coefficients for different interaction terms have an approximate low-dimensional structure and represent each feature by a latent vector in a low-dimensional space. This low-dimensional representation can be viewed as a structured regularization approach that further mitigates overfitting in high-dimensional settings beyond standard regularizers such as the lasso and elastic net. We demonstrate that our approach, called LIT-LVM, achieves superior prediction accuracy compared to the elastic net, hierarchical lasso, and factorization machines on a wide variety of simulated and real data, particularly when the number of interaction terms is high compared to the number of samples. LIT-LVM also provides low-dimensional latent representations for features that are useful for visualizing and analyzing their relationships.

cs.LG

Temporal Motif Participation Profiles for Analyzing Node Similarity in Temporal Networks

Temporal networks consisting of timestamped interactions between a set of nodes provide a useful representation for analyzing complex networked systems that evolve over time. Beyond pairwise interactions between nodes, temporal motifs capture patterns of higher-order interactions such as directed triangles over short time periods. We propose temporal motif participation profiles (TMPPs) to capture the behavior of nodes in temporal motifs. Two nodes with similar TMPPs take similar positions within temporal motifs, possibly with different nodes. TMPPs serve as unsupervised embeddings for nodes in temporal networks that are directly interpretable, as each entry denotes the frequency at which a node participates in a particular position in a specific temporal motif. We demonstrate that clustering TMPPs reveals groups of nodes with similar roles in a temporal network through simulation experiments and a case study on a network of militarized interstate disputes.

cs.SI

Spectral clustering for dependent community Hawkes process models of temporal networks

Temporal networks observed continuously over time through timestamped relational events data are commonly encountered in application settings including online social media communications, financial transactions, and international relations. Temporal networks often exhibit community structure and strong dependence patterns among node pairs. This dependence can be modeled through mutual excitations, where an interaction event from a sender to a receiver node increases the possibility of future events among other node pairs. We provide statistical results for a class of models that we call dependent community Hawkes (DCH) models, which combine the stochastic block model with mutually exciting Hawkes processes for modeling both community structure and dependence among node pairs, respectively. We derive a non-asymptotic upper bound on the misclustering error of spectral clustering on the event count matrix as a function of the number of nodes and communities, time duration, and the amount of dependence in the model. Our result leverages recent results on bounding an appropriate distance between a multivariate Hawkes process count vector and a Gaussian vector, along with results from random matrix theory. We also propose a DCH model that incorporates only self and reciprocal excitation along with highly scalable parameter estimation using a Generalized Method of Moments (GMM) estimator that we demonstrate to be consistent for growing network size and time duration.

stat.ML

A Latent Space Model for HLA Compatibility Networks in Kidney Transplantation

Kidney transplantation is the preferred treatment for people suffering from end-stage renal disease. Successful kidney transplants still fail over time, known as graft failure; however, the time to graft failure, or graft survival time, can vary significantly between different recipients. A significant biological factor affecting graft survival times is the compatibility between the human leukocyte antigens (HLAs) of the donor and recipient. We propose to model HLA compatibility using a network, where the nodes denote different HLAs of the donor and recipient, and edge weights denote compatibilities of the HLAs, which can be positive or negative. The network is indirectly observed, as the edge weights are estimated from transplant outcomes rather than directly observed. We propose a latent space model for such indirectly-observed weighted and signed networks. We demonstrate that our latent space model can not only result in more accurate estimates of HLA compatibilities, but can also be incorporated into survival analysis models to improve accuracy for the downstream task of predicting graft survival times.

cs.LG

The Multivariate Community Hawkes Model for Dependent Relational Events in Continuous-time Networks

The stochastic block model (SBM) is one of the most widely used generative models for network data. Many continuous-time dynamic network models are built upon the same assumption as the SBM: edges or events between all pairs of nodes are conditionally independent given the block or community memberships, which prevents them from reproducing higher-order motifs such as triangles that are commonly observed in real networks. We propose the multivariate community Hawkes (MULCH) model, an extremely flexible community-based model for continuous-time networks that introduces dependence between node pairs using structured multivariate Hawkes processes. We fit the model using a spectral clustering and likelihood-based local refinement procedure. We find that our proposed MULCH model is far more accurate than existing models both for predictive and generative tasks.

stat.ME

A Mutually Exciting Latent Space Hawkes Process Model for Continuous-time Networks

Networks and temporal point processes serve as fundamental building blocks for modeling complex dynamic relational data in various domains. We propose the latent space Hawkes (LSH) model, a novel generative model for continuous-time networks of relational events, using a latent space representation for nodes. We model relational events between nodes using mutually exciting Hawkes processes with baseline intensities dependent upon the distances between the nodes in the latent space and sender and receiver specific effects. We demonstrate that our proposed LSH model can replicate many features observed in real temporal networks including reciprocity and transitivity, while also achieving superior prediction accuracy and providing more interpretable fits than existing models.

cs.LG

Predicting Kidney Transplant Survival using Multiple Feature Representations for HLAs

Kidney transplantation can significantly enhance living standards for people suffering from end-stage renal disease. A significant factor that affects graft survival time (the time until the transplant fails and the patient requires another transplant) for kidney transplantation is the compatibility of the Human Leukocyte Antigens (HLAs) between the donor and recipient. In this paper, we propose 4 new biologically-relevant feature representations for incorporating HLA information into machine learning-based survival analysis algorithms. We evaluate our proposed HLA feature representations on a database of over 100,000 transplants and find that they improve prediction accuracy by about 1%, modest at the patient level but potentially significant at a societal level. Accurate prediction of survival times can improve transplant survival outcomes, enabling better allocation of donors to recipients and reducing the number of re-transplants due to graft failure with poorly matched donors.

cs.LG

A Hybrid Adjacency and Time-Based Data Structure for Analysis of Temporal Networks

Dynamic or temporal networks enable representation of time-varying edges between nodes. Conventional adjacency-based data structures used for storing networks such as adjacency lists were designed without incorporating time and can thus quickly retrieve all edges between two sets of nodes (a node-based slice) but cannot quickly retrieve all edges that occur within a given time interval (a time-based slice). We propose a hybrid data structure for storing temporal networks that stores edges in both an adjacency dictionary, enabling rapid node-based slices, and an interval tree, enabling rapid time-based slices. Our hybrid structure also enables compound slices, where one needs to slice both over nodes and time, either by slicing first over nodes or slicing first over time. We further propose an approach for predictive compound slicing, which attempts to predict whether a node-based or time-based compound slice is more efficient. We evaluate our hybrid data structure on many real temporal network data sets and find that they achieve much faster slice times than existing data structures with only a modest increase in creation time and memory usage.

cs.SI

Learning User Embeddings from Temporal Social Media Data: A Survey

User-generated data on social media contain rich information about who we are, what we like and how we make decisions. In this paper, we survey representative work on learning a concise latent user representation (a.k.a. user embedding) that can capture the main characteristics of a social media user. The learned user embeddings can later be used to support different downstream user analysis tasks such as personality modeling, suicidal risk assessment and purchase decision prediction. The temporal nature of user-generated data on social media has largely been overlooked in much of the existing user embedding literature. In this survey, we focus on research that bridges the gap by incorporating temporal/sequential information in user representation learning. We categorize relevant papers along several key dimensions, identify limitations in the current work and suggest future research directions.

cs.AI

CHIP: A Hawkes Process Model for Continuous-time Networks with Scalable and Consistent Estimation

In many application settings involving networks, such as messages between users of an on-line social network or transactions between traders in financial markets, the observed data consist of timestamped relational events, which form a continuous-time network. We propose the Community Hawkes Independent Pairs (CHIP) generative model for such networks. We show that applying spectral clustering to an aggregated adjacency matrix constructed from the CHIP model provides consistent community detection for a growing number of nodes and time duration. We also develop consistent and computationally efficient estimators for the model parameters. We demonstrate that our proposed CHIP model and estimation procedure scales to large networks with tens of thousands of nodes and provides superior fits than existing continuous-time network models on several real networks.

cs.SI

Personalized Degrees: Effects on Link Formation in Dynamic Networks from an Egocentric Perspective

Understanding mechanisms driving link formation in dynamic social networks is a long-standing problem that has implications to understanding social structure as well as link prediction and recommendation. Social networks exhibit a high degree of transitivity, which explains the successes of common neighbor-based methods for link prediction. In this paper, we examine mechanisms behind link formation from the perspective of an ego node. We introduce the notion of personalized degree for each neighbor node of the ego, which is the number of other neighbors a particular neighbor is connected to. From empirical analyses on four on-line social network datasets, we find that neighbors with higher personalized degree are more likely to lead to new link formations when they serve as common neighbors with other nodes, both in undirected and directed settings. This is complementary to the finding of Adamic and Adar that neighbor nodes with higher (global) degree are less likely to lead to new link formations. Furthermore, on directed networks, we find that personalized out-degree has a stronger effect on link formation than personalized in-degree, whereas global in-degree has a stronger effect than global out-degree. We validate our empirical findings through several link recommendation experiments and observe that incorporating both personalized and global degree into link recommendation greatly improves accuracy.

cs.SI

The Block Point Process Model for Continuous-Time Event-Based Dynamic Networks

We consider the problem of analyzing timestamped relational events between a set of entities, such as messages between users of an on-line social network. Such data are often analyzed using static or discrete-time network models, which discard a significant amount of information by aggregating events over time to form network snapshots. In this paper, we introduce a block point process model (BPPM) for continuous-time event-based dynamic networks. The BPPM is inspired by the well-known stochastic block model (SBM) for static networks. We show that networks generated by the BPPM follow an SBM in the limit of a growing number of nodes. We use this property to develop principled and efficient local search and variational inference procedures initialized by regularized spectral clustering. We fit BPPMs with exponential Hawkes processes to analyze several real network data sets, including a Facebook wall post network with over 3,500 nodes and 130,000 events.

cs.SI

Block CUR: Decomposing Matrices using Groups of Columns

A common problem in large-scale data analysis is to approximate a matrix using a combination of specifically sampled rows and columns, known as CUR decomposition. Unfortunately, in many real-world environments, the ability to sample specific individual rows or columns of the matrix is limited by either system constraints or cost. In this paper, we consider matrix approximation by sampling predefined \emph{blocks} of columns (or rows) from the matrix. We present an algorithm for sampling useful column blocks and provide novel guarantees for the quality of the approximation. This algorithm has application in problems as diverse as biometric data analysis to distributed computing. We demonstrate the effectiveness of the proposed algorithms for computing the Block CUR decomposition of large matrices in a distributed setting with multiple nodes in a compute cluster, where such blocks correspond to columns (or rows) of the matrix stored on the same node, which can be retrieved with much less overhead than retrieving individual columns stored across different nodes. In the biometric setting, the rows correspond to different users and columns correspond to users' biometric reaction to external stimuli, {\em e.g.,}~watching video content, at a particular time instant. There is significant cost in acquiring each user's reaction to lengthy content so we sample a few important scenes to approximate the biometric response. An individual time sample in this use case cannot be queried in isolation due to the lack of context that caused that biometric reaction. Instead, collections of time segments ({\em i.e.,} blocks) must be presented to the user. The practical application of these algorithms is shown via experimental results using real-world user biometric data from a content testing environment.

stat.ML

Leveraging Friendship Networks for Dynamic Link Prediction in Social Interaction Networks

On-line social networks (OSNs) often contain many different types of relationships between users. When studying the structure of OSNs such as Facebook, two of the most commonly studied networks are friendship and interaction networks. The link prediction problem in friendship networks has been heavily studied. There has also been prior work on link prediction in interaction networks, independent of friendship networks. In this paper, we study the predictive power of combining friendship and interaction networks. We hypothesize that, by leveraging friendship networks, we can improve the accuracy of link prediction in interaction networks. We augment several interaction link prediction algorithms to incorporate friendships and predicted friendships. From experiments on Facebook data, we find that incorporating friendships into interaction link prediction algorithms results in higher accuracy, but incorporating predicted friendships does not when compared to incorporating current friendships.

cs.SI

DyLink2Vec: Effective Feature Representation for Link Prediction in Dynamic Networks

The temporal dynamics of a complex system such as a social network or a communication network can be studied by understanding the patterns of link appearance and disappearance over time. A critical task along this understanding is to predict the link state of the network at a future time given a collection of link states at earlier time points. In existing literature, this task is known as link prediction in dynamic networks. Solving this task is more difficult than its counterpart in static networks because an effective feature representation of node-pair instances for the case of dynamic network is hard to obtain. To overcome this problem, we propose a novel method for metric embedding of node-pair instances of a dynamic network. The proposed method models the metric embedding task as an optimal coding problem where the objective is to minimize the reconstruction error, and it solves this optimization task using a gradient descent method. We validate the effectiveness of the learned feature representation by utilizing it for link prediction in various real-life dynamic networks. Specifically, we show that our proposed link prediction model, which uses the extracted feature representation for the training instances, outperforms several existing methods that use well-known link prediction features.

cs.SI

Unsupervised Motion Artifact Detection in Wrist-Measured Electrodermal Activity Data

One of the main benefits of a wrist-worn computer is its ability to collect a variety of physiological data in a minimally intrusive manner. Among these data, electrodermal activity (EDA) is readily collected and provides a window into a person's emotional and sympathetic responses. EDA data collected using a wearable wristband are easily influenced by motion artifacts (MAs) that may significantly distort the data and degrade the quality of analyses performed on the data if not identified and removed. Prior work has demonstrated that MAs can be successfully detected using supervised machine learning algorithms on a small data set collected in a lab setting. In this paper, we demonstrate that unsupervised learning algorithms perform competitively with supervised algorithms for detecting MAs on EDA data collected in both a lab-based setting and a real-world setting comprising about 23 hours of data. We also find, somewhat surprisingly, that incorporating accelerometer data as well as EDA improves detection accuracy only slightly for supervised algorithms and significantly degrades the accuracy of unsupervised algorithms.

cs.HC

Effects of Contact Network Models on Stochastic Epidemic Simulations

The importance of modeling the spread of epidemics through a population has led to the development of mathematical models for infectious disease propagation. A number of empirical studies have collected and analyzed data on contacts between individuals using a variety of sensors. Typically one uses such data to fit a probabilistic model of network contacts over which a disease may propagate. In this paper, we investigate the effects of different contact network models with varying levels of complexity on the outcomes of simulated epidemics using a stochastic Susceptible-Infectious-Recovered (SIR) model. We evaluate these network models on six datasets of contacts between people in a variety of settings. Our results demonstrate that the choice of network model can have a significant effect on how closely the outcomes of an epidemic simulation on a simulated network match the outcomes on the actual network constructed from the sensor data. In particular, preserving degrees of nodes appears to be much more important than preserving cluster structure for accurate epidemic simulations.

cs.SI