arXiv subjects

Kewen Chen

Publications and source records attributed to Kewen Chen.

3 recordsLinked to original sources

arXiv2026

A multi-architecture study of specificity refinement and false-positive mechanism analysis in prostate MRI

Objectives: To characterize residual false positives in prostate MRI detection, and to evaluate a lightweight post-hoc refinement head for case-level specificity. Materials and Methods: This retrospective study used PI-CAI (5-fold cross-validation) and Prostate158 (n=158; external). A context-aware evidence head and an 89,216-parameter refinement head were trained on a frozen detection backbone; the evidence head was also trained on four further backbones (bare nnU-Net, bare U-Net, bare Mamba, MIGF-Mamba). For each false-positive region, T2-weighted, apparent-diffusion-coefficient, and high-b-value contrast ratios versus peri-lesional rings were compared against ground-truth lesions and contralateral benign regions. Results: False positives were closer to true cancers than to benign tissue in evidence and raw T2-weighted and apparent-diffusion-coefficient contrast, reproducing 35/35 across five architectures (Cohen's d 1.10; FP/benign evidence ratio 2.38x) and 105/105 across modality-perturbation scenarios. On PI-CAI fold-0, refinement raised case-level specificity from 0.469 to 0.549 (+17.2%) at preserved sensitivity (0.943); 5-fold cross-validation showed fold-conditional behavior (9/15 observations positive; range -22% to +28%). On Prostate158, both models saturated (McNemar pooled p=0.69), while the false-positive contrast-matching finding replicated. Conclusion: Residual false positives are contrast-matched to cancer (sharing raw imaging features rather than histologically confirmed mimicry), reproducing across five architectures -- a data-level imaging property, not model-specific artifacts; post-hoc refinement adds practical specificity in-domain but is fold-conditional.

eess.IV↗

arXiv2026

Backbone-Conditional Behavior of Modality Gating in Multi-Modal Prostate MRI Segmentation: A 5-Fold Cross-Validation and Gate Mechanism Analysis

Robust segmentation of clinically significant prostate cancer (csPCa) on multi-parametric MRI must tolerate frequent degradation of its most informative diffusion sequences. Multi-modal fusion commonly employs learned modality gating under the assumption that gates implement per-sample modality quality routing -- rarely tested directly. We ask how gating behaves across backbone architectures. We systematically analyze modality-isolated gated fusion (MIGF) for csPCa segmentation on two backbones (nnU-Net and Mamba) using PI-CAI (n=1500), with cross-cohort validation on Prostate158 (n=158): a factorial ablation over gating, modality dropout, and deep supervision under 5-fold cross-validation (180 trained models), plus a gate-weight and counterfactual analysis of 30 trained gating models. Modality gating is backbone-conditional. On nnU-Net, adding gating reduces the ranking score (marginal effect -0.037; gating configurations p<0.05), whereas on Mamba the gating-plus-dropout configuration improves it (+0.024, p=0.037). Gate-weight analysis explains this: nnU-Net gates collapse into a near-static modality prior (across-case SD 0.0033), while Mamba gates retain sample-dependent variation (0.0365, ~11x larger, non-overlapping); replacing per-sample gates with their training-set mean leaves nnU-Net unchanged but degrades Mamba. Modality dropout is the only component beneficial on both backbones. Under cross-cohort shift, convolutional backbones collapse to case-level specificity near zero, whereas Mamba retains it (MIGF-Mamba highest, 0.31). Learned modality gates do not universally perform per-sample quality routing; their effective behavior is conditional on the backbone's inherent modality awareness. Among tested configurations, MIGF-Mamba is the most cross-cohort robust, and training-time modality dropout is the only component beneficial across both backbones.

cs.CV↗

arXiv2025

Identity-Preserving Text-to-Image Generation via Dual-Level Feature Decoupling and Expert-Guided Fusion

Recent advances in large-scale text-to-image generation models have led to a surge in subject-driven text-to-image generation, which aims to produce customized images that align with textual descriptions while preserving the identity of specific subjects. Despite significant progress, current methods struggle to disentangle identity-relevant information from identity-irrelevant details in the input images, resulting in overfitting or failure to maintain subject identity. In this work, we propose a novel framework that improves the separation of identity-related and identity-unrelated features and introduces an innovative feature fusion mechanism to improve the quality and text alignment of generated images. Our framework consists of two key components: an Implicit-Explicit foreground-background Decoupling Module (IEDM) and a Feature Fusion Module (FFM) based on a Mixture of Experts (MoE). IEDM combines learnable adapters for implicit decoupling at the feature level with inpainting techniques for explicit foreground-background separation at the image level. FFM dynamically integrates identity-irrelevant features with identity-related features, enabling refined feature representations even in cases of incomplete decoupling. In addition, we introduce three complementary loss functions to guide the decoupling process. Extensive experiments demonstrate the effectiveness of our proposed method in enhancing image generation quality, improving flexibility in scene adaptation, and increasing the diversity of generated outputs across various textual descriptions.

cs.CV↗