arXiv subjects

Kexin Cao

Publications and source records attributed to Kexin Cao.

4 recordsLinked to original sources

arXiv2026

RareLens: Towards End-to-End Rare Disease Care via Aligning Divergent Large Language Model Reasoning

Rare diseases represent one of the most challenging settings for clinical decision-making, where heterogeneous presentations, sparse evidence and limited expertise create persistent uncertainty throughout the care pathway. Although artificial intelligence could help, existing systems largely address isolated tasks, particularly diagnosis, and usually rely on downstream investigations rather than information available at initial presentation. Here we show that clinical AI performance under uncertainty can be improved not by scaling a single model, but by exploiting the diversity of multiple imperfect reasoning systems. Across heterogeneous large language models, we identify divergent reasoning trajectories with complementary error patterns and develop RareLens, which learns to reconcile these perspectives into actionable decisions across four stages of rare disease care: risk screening, diagnosis, treatment planning and prognosis prediction. Built on RarelensBench, a real-world dataset of 157,525 cases spanning all 33 Orphanet categories and more than 7,000 conditions, RareLens outperformed every frontier model tested, including GPT-5, DeepSeek-R1, Claude-3.7-Sonnet and Gemini-2.5-Pro, across all stages. It achieved an area under the curve of 0.917 for screening and top-1 accuracies of 65.5% and 89.8% for diagnosis and treatment. In an external evaluation involving 1,287 cases and 23 physicians, autonomous RareLens and physicians assisted by RareLens both outperformed unaided physicians, while demonstrating that effective human-AI collaboration requires more than simply providing model outputs. These findings establish divergent model reasoning as an exploitable source of information and suggest a general strategy for building AI systems that operate reliably under high clinical uncertainty.

cs.AI↗

arXiv2026

Auditing Training Data in Generative Music Models via Black-Box Membership Inference

Recent advances in text-to-music generation enable high-fidelity synthesis of structured musical audio, raising growing concerns about data provenance, consent, and training transparency. These models are typically trained on large-scale corpora with little disclosure, leaving no practical mechanism to verify whether a particular audio sample was included in training. In this paper, we investigate black-box membership inference for generative music models, aiming to determine whether a candidate music sample was used during training, given only query access to the deployed system. Our key insight is that training membership induces systematically stronger semantic and structural alignment between a candidate sample and the model's generation conditioned on its caption. We query the target model with the associated caption and measure the relationship between the candidate audio and the generated output in a learned feature space. To capture features that separate members from non-members, we construct paired examples consisting of each track and its caption-conditioned generation from shadow models, and train a music auditor to classify membership. The auditor captures alignment patterns characteristic of training membership and generalizes to unseen target models in a fully black-box setting without access to model parameters or training metadata. Across multiple state-of-the-art music generators, our method achieves up to 98.6% accuracy, with false-positive and false-negative rates as low as 1.9% and 1.0%, demonstrating that reliable training-data auditing is feasible in realistic deployment scenarios.

cs.LG↗

arXiv2026

SkillX: Automatically Constructing Skill Knowledge Bases for Agents

Learning from experience is critical for building capable large language model (LLM) agents, yet prevailing self-evolving paradigms remain inefficient: agents learn in isolation, repeatedly rediscover similar behaviors from limited experience, resulting in redundant exploration and poor generalization. To address this problem, we propose SkillX, a fully automated framework for constructing a \textbf{plug-and-play skill knowledge base} that can be reused across agents and environments. SkillX operates through a fully automated pipeline built on three synergistic innovations: \textit{(i) Multi-Level Skills Design}, which distills raw trajectories into three-tiered hierarchy of strategic plans, functional skills, and atomic skills; \textit{(ii) Iterative Skills Refinement}, which automatically revises skills based on execution feedback to continuously improve library quality; and \textit{(iii) Exploratory Skills Expansion}, which proactively generates and validates novel skills to expand coverage beyond seed training data. Using a strong backbone agent (GLM-4.6), we automatically build a reusable skill library and evaluate its transferability on challenging long-horizon, user-interactive benchmarks, including AppWorld, BFCL-v3, and $τ^2$-Bench. Experiments show that SkillKB consistently improves task success and execution efficiency when plugged into weaker base agents, highlighting the importance of structured, hierarchical experience representations for generalizable agent learning. Our code will be publicly available soon at https://github.com/zjunlp/SkillX.

cs.CL↗

arXiv2026

Public Access Defibrillator Deployment for Cardiac Arrests: A Learn-Then-Optimize Approach with SHAP-based Interpretable Analytics

Out-of-hospital cardiac arrest (OHCA) survival rates remain extremely low due to challenges in the timely accessibility of medical devices. Therefore, effective deployment of automated external defibrillators (AED) can significantly increase survival rates. Precise and interpretable predictions of OHCA occurrences provide a solid foundation for efficient and robust AED deployment optimization. This study develops a novel learn-then-optimize approach, integrating three key components: a machine learning prediction model, SHAP-based interpretable analytics, and a SHAP-guided integer programming (SIP) model. The machine learning model is trained utilizing only geographic data as inputs to overcome data availability obstacles, and its strong predictive performance validates the feasibility of interpretation. Furthermore, the SHAP model elaborates on the contribution of each geographic feature to the OHCA occurrences. Finally, an integer programming model is formulated for optimizing AED deployment, incorporating SHAP-weighted OHCA densities. Various numerical experiments are conducted across different settings. Based on comparative and sensitive analysis, the optimization effect of our approach is verified and valuable insights are derived to provide substantial support for theoretical extension and practical implementation.

math.OC↗