arXiv subjects

Kexuan Li

Publications and source records attributed to Kexuan Li.

24 records · Page 2Linked to original sources

arXiv2023

Multivariate Rank-Based Analysis of Multiple Endpoints in Clinical Trials: A Global Test Approach

Clinical trials often involve the assessment of multiple endpoints to comprehensively evaluate the efficacy and safety of interventions. In the work, we consider a global nonparametric testing procedure based on multivariate rank for the analysis of multiple endpoints in clinical trials. Unlike other existing approaches that rely on pairwise comparisons for each individual endpoint, the proposed method directly incorporates the multivariate ranks of the observations. By considering the joint ranking of all endpoints, the proposed approach provides robustness against diverse data distributions and censoring mechanisms commonly encountered in clinical trials. Through extensive simulations, we demonstrate the superior performance of the multivariate rank-based approach in controlling type I error and achieving higher power compared to existing rank-based methods. The simulations illustrate the advantages of leveraging multivariate ranks and highlight the robustness of the approach in various settings. The proposed method offers an effective tool for the analysis of multiple endpoints in clinical trials, enhancing the reliability and efficiency of outcome evaluations.

stat.ME↗

arXiv2023

On the Confidence Intervals in Bioequivalence Studies

A bioequivalence study is a type of clinical trial designed to compare the biological equivalence of two different formulations of a drug. Such studies are typically conducted in controlled clinical settings with human subjects, who are randomly assigned to receive two formulations. The two formulations are then compared with respect to their pharmacokinetic profiles, which encompass the absorption, distribution, metabolism, and elimination of the drug. Under the guidance from Food and Drug Administration (FDA), for a size-$α$ bioequivalence test, the standard approach is to construct a $100(1-2α)\%$ confidence interval and verify if the confidence interval falls with the critical region. In this work, we clarify that $100(1-2α)\%$ confidence interval approach for bioequivalence testing yields a size-$α$ test only when the two one-sided tests in TOST are ``equal-tailed''. Furthermore, a $100(1-α)\%$ confidence interval approach is also discussed in the bioequivalence study.

stat.ME↗

arXiv2022

Variable selection for nonlinear Cox regression model via deep learning

Variable selection problem for the nonlinear Cox regression model is considered. In survival analysis, one main objective is to identify the covariates that are associated with the risk of experiencing the event of interest. The Cox proportional hazard model is being used extensively in survival analysis in studying the relationship between survival times and covariates, where the model assumes that the covariate has a log-linear effect on the hazard function. However, this linearity assumption may not be satisfied in practice. In order to extract a representative subset of features, various variable selection approaches have been proposed for survival data under the linear Cox model. However, there exists little literature on variable selection for the nonlinear Cox model. To break this gap, we extend the recently developed deep learning-based variable selection model LassoNet to survival data. Simulations are provided to demonstrate the validity and effectiveness of the proposed method. Finally, we apply the proposed methodology to analyze a real data set on diffuse large B-cell lymphoma.

stat.ML↗

arXiv2020

A Computationally Efficient Classification Algorithm in Posterior Drift Model: Phase Transition and Minimax Adaptivity

In massive data analysis, training and testing data often come from very different sources, and their probability distributions are not necessarily identical. A feature example is nonparametric classification in posterior drift model where the conditional distributions of the label given the covariates are possibly different. In this paper, we derive minimax rate of the excess risk for nonparametric classification in posterior drift model in the setting that both training and testing data have smooth distributions, extending a recent work by Cai and Wei (2019) who only impose smoothness condition on the distribution of testing data. The minimax rate demonstrates a phase transition characterized by the mutual relationship between the smoothness orders of the training and testing data distributions. We also propose a computationally efficient and data-driven nearest neighbor classifier which achieves the minimax excess risk (up to a logarithm factor). Simulation studies and a real-world application are conducted to demonstrate our approach.

math.ST↗

arXiv2019

On the Convergence Rate of the Quasi- to Stationary Distribution for the Shiryaev-Roberts Diffusion

For the classical Shiryaev--Roberts martingale diffusion considered on the interval $[0,A]$, where $A>0$ is a given absorbing boundary, it is shown that the rate of convergence of the diffusion's quasi-stationary cumulative distribution function (cdf), $Q_{A}(x)$, to its stationary cdf, $H(x)$, as $A\to+\infty$, is no worse than $O(\log(A)/A)$, uniformly in $x\ge0$. The result is established explicitly, by constructing new tight lower- and upper-bounds for $Q_{A}(x)$ using certain latest monotonicity properties of the modified Bessel $K$ function involved in the exact closed-form formula for $Q_{A}(x)$ recently obtained by Polunchenko (2017).

stat.CO↗

arXiv2019

Analytic Evaluation of the Fractional Moments for the Quasi-Stationary Distribution of the Shiryaev Martingale on an Interval

We consider the quasi-stationary distribution of the classical Shiryaev diffusion restricted to the interval $[0,A]$ with absorption at a fixed $A>0$. We derive analytically a closed-form formula for the distribution's fractional moment of an {\em arbitrary} given order $s\in\mathbb{R}$; the formula is consistent with that previously found by Polunchenko and Pepelyshev (2018) for the case of $s\in\mathbb{N}$. We also show by virtue of the formula that, if $s<1$, then the $s$-th fractional moment of the quasi-stationary distribution becomes that of the exponential distribution (with mean $1/2$) in the limit as $A\to+\infty$; the limiting exponential distribution is the stationary distribution of the reciprocal of the Shiryaev diffusion.

stat.CO↗