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Kithmin Wickremasinghe

Publications and source records attributed to Kithmin Wickremasinghe.

7 recordsLinked to original sources

A Dry-Contact Ear-EEG System With Continuous Electrode-Skin Impedance Mismatch Monitoring for Motion Artifact Cancellation Using DRL Stimulus

Dry-contact ear-electroencephalography (Ear-EEG) enables wearable neural monitoring. However, motion induced electrode-skin impedance (ESI) mismatches between electrodes can severely degrade signal quality. To the best of our knowledge, this paper presents the first proof-of-concept dry-contact EarEEG system that uses a driven-right-leg (DRL) stimulus for continuous ESI mismatch monitoring, enabling online adaptive motion artifact cancellation. A 1 kHz sinusoidal stimulus is injected through the DRL electrode. The resulting response to the injected carrier is separated from the EEG using bandpass filtering and demodulation, and then used to extract the ESI mismatch information as the reference input for a normalized least-mean-square adaptive filter followed by a Hampel filtering stage. To evaluate artifact suppression and preservation of neural activity, alpha-band EEG activity was analyzed involving four healthy participants performing head nodding, electrode tapping, and jaw clenching. The system achieved artifact power reductions of 6.5, 12.6, and 9.0 dB (77.6%, 92.8%, and 86.4%, respectively) while alpha-band modulation remained clearly observable after processing. This demonstrates the feasibility of DRL-stimulusbased ESI mismatch monitoring for motion artifact cancellation in wearable dry-contact Ear-EEG.

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A 2.4 GHz LC-VCO Fractional-N Phase Locked Loop Open-Source Design in 130-nm BiCMOS

Radio frequency (RF) integrated circuit design using the open-source complementary Metal-Oxide semiconductor (CMOS) ecosystem, such as for phase-locked loops (PLLs), is limited by the absence of reliable passive device models, particularly on-chip spiral inductors. Consequently, prior work relies on ring-oscillator-based voltage-controlled oscillators (VCOs) with degraded phase noise performance. This work presents a 2.4 GHz type-II fractional-N PLL implemented in the IHP SG13G2 130 nm BiCMOS open-source technology. The proposed design employs a cross-coupled differential LC-VCO integrated with a custom-designed spiral inductor, developed using an open-source electromagnetic modelling workflow in OpenEMS. The optimized inductor achieves 4 nH inductance with a quality factor of 16.8 at 2.45 GHz. The LC-VCO sensitivity is approximately 120 MHz/V, while the PLL phase noise is -100.8 dBc/Hz at 1 MHz offset. The complete PLL is realized using a fully open-source electronic design automation (EDA) flow, occupying a total area of 930 um x 666 um (~0.619 mm2) and consuming 12.73 mW, demonstrating the feasibility of RF integrated circuit design in an open-source CMOS IC design ecosystem.

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Area Optimization of Open-Source Low-Power INA in 130nm CMOS using Hybrid Mixed-Variable PSO

As open-source silicon initiatives democratize access to integrated circuit development using multi-project environments, silicon area has become a premium resource. However, minimizing this layout area traditionally forces designers to compromise on core performance specifications. To address this challenge, this paper presents an open-source framework based on a hybrid mixed-variable particle swarm optimization algorithm and the gm/ID methodology to minimize the layout area of complex analog circuits while meeting design requirements. The framework's efficacy is demonstrated by designing a low-power instrumentation amplifier that achieves a 90.33% reduction in gate area over existing implementations.

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A Patient-Independent Neonatal Seizure Prediction Model Using Reduced Montage EEG and ECG

Neonates are highly susceptible to seizures, often leading to short or long-term neurological impairments. However, clinical manifestations of neonatal seizures are subtle and often lead to misdiagnoses. This increases the risk of prolonged, untreated seizure activity and subsequent brain injury. Continuous video electroencephalogram (cEEG) monitoring is the gold standard for seizure detection. However, this is an expensive evaluation that requires expertise and time. In this study, we propose a convolutional neural network-based model for early prediction of neonatal seizures by distinguishing between interictal and preictal states of the EEG. Our model is patient-independent, enabling generalization across multiple subjects, and utilizes mel-frequency cepstral coefficient matrices extracted from multichannel EEG and electrocardiogram (ECG) signals as input features. Trained and validated on the Helsinki neonatal EEG dataset with 10-fold cross-validation, the proposed model achieved an average accuracy of 97.52%, sensitivity of 98.31%, specificity of 96.39%, and F1-score of 97.95%, enabling accurate seizure prediction up to 30 minutes before onset. The inclusion of ECG alongside EEG improved the F1-score by 1.42%, while the incorporation of an attention mechanism yielded an additional 0.5% improvement. To enhance transparency, we incorporated SHapley Additive exPlanations (SHAP) as an explainable artificial intelligence method to interpret the model and provided localization of seizure focus using scalp plots. The overall results demonstrate the model's potential for minimally supervised deployment in neonatal intensive care units, enabling timely and reliable prediction of neonatal seizures, while demonstrating strong generalization capability across unseen subjects through transfer learning.

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A Simultaneous ECG-PCG Acquisition System with Real-Time Burst-Adaptive Noise Cancellation

Cardiac auscultation is an essential clinical skill, requiring excellent hearing to distinguish subtle differences in timing and pitch of heart sounds. However, diagnosing solely from these sounds is often challenging due to interference from surrounding noise, and the information may be limited. Most of the existing solutions that adaptively cancel external noise are either non-real-time or computationally intensive, making them unsuitable for implementation in a portable system. This work proposes an end-to-end system with a real-time adaptive noise cancellation pipeline integrated into a device that simultaneously acquires electrocardiogram (ECG) and phonocardiogram (PCG) signals. We employ a burst-adaptive normalized least mean square algorithm that adjusts its adaptation in response to high-energy, non-stationary hospital noise. The algorithm's performance was initially assessed using datasets with artificially induced noise. Subsequently, the complete end-to-end system was validated using real-world hospital recordings captured with the dual-modality device. For ECG and PCG signals recorded from the device in noisy hospital settings, the proposed system achieved signal-to-noise ratio improvements of 30.32 dB and 37.01 dB, respectively. Furthermore, complexity analysis confirms the pipeline's suitability for embedded implementation. These results demonstrate the system's effectiveness in enabling reliable and accessible cardiac screening in noisy hospital environments typical of resource-constrained settings.

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An Active Dry-Contact Continuous EEG Monitoring System for Seizure Detection Applications in Clinical Neurophysiology

Objective: Young children and infants, especially newborns, are highly susceptible to seizures, which, if undetected and untreated, can lead to severe long-term neurological consequences. Early detection typically requires continuous electroencephalography (cEEG) monitoring in hospital settings, involving costly equipment and highly trained specialists. This study presents a low-cost, active dry-contact electrode-based, adjustable electroencephalography (EEG) headset, combined with an explainable deep learning model for seizure detection from reduced-montage EEG, and a multimodal artifact removal algorithm to enhance signal quality. Methods: EEG signals were acquired via active electrodes and processed through a custom-designed analog front end for filtering and digitization. The adjustable headset was fabricated using three-dimensional printing and laser cutting to accommodate varying head sizes. The deep learning model was trained to detect neonatal seizures in real time, and a dedicated multimodal algorithm was implemented for artifact removal while preserving seizure-relevant information. System performance was evaluated in a representative clinical setting on a pediatric patient with absence seizures, with simultaneous recordings obtained from the proposed device and a commercial wet-electrode cEEG system for comparison. Results: Signals from the proposed system exhibited a correlation coefficient exceeding 0.8 with those from the commercial device. Signal-to-noise ratio analysis indicated noise mitigation performance comparable to the commercial system. The deep learning model achieved accuracy and recall improvements of 2.76% and 16.33%, respectively, over state-of-the-art approaches. The artifact removal algorithm effectively identified and eliminated noise while preserving seizure-related EEG features.

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Using Explainable AI for EEG-based Reduced Montage Neonatal Seizure Detection

The neonatal period is the most vulnerable time for the development of seizures. Seizures in the immature brain lead to detrimental consequences, therefore require early diagnosis. The gold-standard for neonatal seizure detection currently relies on continuous video-EEG monitoring; which involves recording multi-channel electroencephalogram (EEG) alongside real-time video monitoring within a neonatal intensive care unit (NICU). However, video-EEG monitoring technology requires clinical expertise and is often limited to technologically advanced and resourceful settings. Cost-effective new techniques could help the medical fraternity make an accurate diagnosis and advocate treatment without delay. In this work, a novel explainable deep learning model to automate the neonatal seizure detection process with a reduced EEG montage is proposed, which employs convolutional nets, graph attention layers, and fully connected layers. Beyond its ability to detect seizures in real-time with a reduced montage, this model offers the unique advantage of real-time interpretability. By evaluating the performance on the Zenodo dataset with 10-fold cross-validation, the presented model achieves an absolute improvement of 8.31% and 42.86% in area under curve (AUC) and recall, respectively.

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