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Konstantin Doubrovinski

Publications and source records attributed to Konstantin Doubrovinski.

2 recordsLinked to original sources

When are two algorithms the same? Towards addressing Hilbert's 24th problem

The informal question of when two theorem proofs are "essentially the same" goes back to David Hilbert, who considered adding it (or something largely equivalent) to his famous list of open problems, but eventually decided to leave it out. Given that the notion of a formal proof is closely related to that of a (computer) program, i.e. a recursive function, it may be useful to ask the same question with regard to programs instead. Here we propose a minimalistic approach to this question within Recursion Theory, building heavily on the use of Kolmogorov Complexity.

cs.LO

Stochastic model for Soj relocation dynamics in Bacillus subtilis

The Bacillus subtilis Spo0J/Soj proteins, implicated in chromosome segregation and transcriptional regulation, show striking dynamics: Soj undergoes irregular relocations from pole to pole or nucleoid to nucleoid. Here we report on a mathematical model of the Soj dynamics. Our model, which is closely based on the available experimental data, readily generates dynamic Soj relocations. We show that the irregularity of the relocations may be due to the stochastic nature of the underlying Spo0J/Soj interactions and diffusion. We propose explanations for the behavior of several Spo0J/Soj mutants including the "freezing" of the Soj dynamics observed in filamentous cells. Our approach underlines the importance of incorporating stochastic effects when modelling spatiotemporal protein dynamics inside cells.

q-bio.SC