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Konstantinos Moutselos

Publications and source records attributed to Konstantinos Moutselos.

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Conditioning noise is a free regularizer for LoRA fine-tuning: no pathology encoder required for diffusion-based artifact detection in histopathology

Diffusion-based artifact detectors score whole-slide image patches by reconstruction error under a model fine-tuned on clean tissue. We show that conditioning this fine-tuning on random Gaussian embeddings -- resampled at every step from approx. 200 KB of precomputed embedding statistics, with no encoder, no cache, and no change to inference -- consistently widens the clean/artifact separation. A four-step ablation chain shows the benefit requires neither content (shuffled real embeddings), provenance (synthetic Gaussians), a tuned intensity (flat across an 8x variance range), nor per-patch identity (fresh per-step noise); a LoRA-dropout control shows the conditioning pathway specifically, not generic weight perturbation, carries the effect. Patch-level gains of +0.25-0.48 Cohen's d replicate across nine trainings; honest leave-one-slide-out evaluation clears a pre-registered bar in 2/2 seeds; and two pre-registered external endpoints on a 281-case set confirm pooled Delta F1 = +0.0073 (95% CI) and +0.0129 (97.5% CI, two-look corrected). We release the full evaluation protocol, including measured seed noise and selection-optimism pricing.

eess.IV

Reliable Benchmarking of Artifact Detection in Computational Pathology: A Reproducibility and Uncertainty Analysis

Background and Objective: Quality control is a prerequisite for whole-slide image analysis, yet the benchmarks on which quality-control methods are compared share four properties that make their reported differences hard to interpret: few independent slides, annotation concentrated in a minority of them, pooled ratio metrics with no closed-form standard error, and a single inherited train/test partition. We propose a reliability protocol for such benchmarks. Methods: The protocol quantifies four sources of variability - test-set sampling, training stochasticity, partition composition, and undocumented preprocessing - a claim is reportable only if it survives all four; three of the four cost minutes of compute. We apply it to an independent reconstruction of a published diffusion-based artifact detector, evaluated on the original 24-slide partition and against a supervised baseline. Results: The method's central mechanism reproduces: the auxiliary contrastive term improves pooled F1 from 0.673 to 0.688 and replicates under a second seed (+0.0156, p = 0.031; +0.0190, p = 0.005), although it acts on pen marking rather than the artifact types cited to motivate it. Its comparative claims do not: differences between design variants, and against the supervised baseline, fall inside the uncertainty of the evaluation. Four of 24 slides carry 70% of scored annotated pixels, giving an effective sample size of 6.2, and the inherited partition sits at the 7th percentile. An unreported tissue-restriction step excludes 41.4% of out-of-focus annotation against 2.6% of air bubble; such a gate is confounded with blur by construction. Conclusions: Small-cohort benchmarks support far weaker conclusions than current reporting implies. The four checks are cheap enough to accompany any evaluation on such a resource and separate reproducible effects from differences the evaluation cannot resolve.

cs.CV

Zero-Shot Generative De-identification: Inversion-Free Flow for Privacy-Preserving Skin Image Analysis

The secure analysis of dermatological images in clinical environments is fundamentally restricted by the critical trade-off between patient privacy and the preservation of diagnostic fidelity. Traditional de-identification techniques often degrade essential pathological markers, while state-of-the-art generative approaches typically require computationally intensive inversion processes or extensive task-specific fine-tuning, limiting their feasibility for real-time deployment. This study introduces a zero-shot generative de-identification framework that utilizes an inversion-free pipeline for privacy-preserving medical image analysis. By leveraging Rectified Flow Transformers (FlowEdit), the proposed method achieves high-fidelity identity transformation in less than 20 seconds without requiring pathology-specific training or labeled datasets. We introduce a novel "segment-by-synthesis" mechanism that generates counterfactual "healthy" and "pathological" digital twin pairs to isolate clinical signals from biometric identifiers in a zero-shot manner. Our approach specifically utilizes the CIELAB color space to decouple erythema-related pathological signals from semantic noise and individual skin characteristics. Pilot validation on high-resolution clinical samples demonstrates robust stability in preserving pathological features, achieving an Intersection over Union (IoU) stability exceeding 0.67, while ensuring rigorous de-identification. These results suggest that the proposed zero-shot, inversion-free approach provides a scalable and efficient solution for secure data sharing and collaborative biomedical research, bypassing the need for large-scale annotated medical datasets while aligning with data protection standards.

cs.CV

Zero-shot Segmentation of Skin Conditions: Erythema with Edit-Friendly Inversion

This study proposes a zero-shot image segmentation framework for detecting erythema (redness of the skin) using edit-friendly inversion in diffusion models. The method synthesizes reference images of the same patient that are free from erythema via generative editing and then accurately aligns these references with the original images. Color-space analysis is performed with minimal user intervention to identify erythematous regions. This approach significantly reduces the reliance on labeled dermatological datasets while providing a scalable and flexible diagnostic support tool by avoiding the need for any annotated training masks. In our initial qualitative experiments, the pipeline successfully isolated facial erythema in diverse cases, demonstrating performance improvements over baseline threshold-based techniques. These results highlight the potential of combining generative diffusion models and statistical color segmentation for computer-aided dermatology, enabling efficient erythema detection without prior training data.

cs.CV

Setting a Baseline for long-shot real-time Player and Ball detection in Soccer Videos

Players and ball detection are among the first required steps on a football analytics platform. Until recently, the existing open datasets on which the evaluations of most models were based, were not sufficient. In this work, we point out their weaknesses, and with the advent of the SoccerNet v3, we propose and deliver to the community an edited part of its dataset, in YOLO normalized annotation format for training and evaluation. The code of the methods and metrics are provided so that they can be used as a benchmark in future comparisons. The recent YOLO8n model proves better than FootAndBall in long-shot real-time detection of the ball and players on football fields.

cs.CV