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Kun Zhao

Publications and source records attributed to Kun Zhao.

At least 19 recordsLinked to original sources

Remarkable Enhancement of High Harmonic Generation from Superhard Material under High Pressure

High harmonic generation (HHG) in solids offers a pathway to develop compact extreme ultraviolet (EUV) sources crucial for attosecond science and advanced spectroscopy. Here, we demonstrate theoretically that high pressure dramatically enhances HHG in superhard hexagonal tungsten nitride (h-WN6). Compared with solid-state systems at ambient pressure, the reshaped electronic environment under high pressure leads to a unique band-gap widening in h-WN6, which raises the material's damage threshold, allowing the use of stronger laser fields and enabling access to higher-energy bands. This pressure-induced band-gap widening offers a promising strategy to overcome the cutoff limitation of solid-state EUV light sources.

physics.optics

Longitudinal Bayesian Learning of Continuous Disease Position across the Alzheimer's Disease Continuum

Alzheimer's disease (AD) progresses as a continuous biological process, whereas most existing neuroimaging-based artificial intelligence methods remain limited to discrete diagnosis or clinical score prediction from cross-sectional imaging. In this work, we propose Disease Continuum Positioning (DCP), a longitudinal Bayesian Learning framework that continuously estimates disease severity from longitudinal diffusion tensor imaging (DTI). Specifically, DCP models disease severity as a low-dimensional probabilistic latent variable by jointly integrating longitudinal observations with weak clinical supervision, from which the proposed Disease Continuum Score (DCS) is derived to quantify an individual's position along the Alzheimer's disease continuum together with its associated uncertainty. Extensive experiments on the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort demonstrate that DCP consistently outperforms representative disease progression methods. More importantly, comprehensive validation analyses show that DCS accurately characterizes disease severity, exhibits strong clinical relevance, preserves longitudinal disease evolution, and predicts future disease conversion. These results suggest that DCS provides a quantitative imaging-derived representation for continuous assessment of Alzheimer's disease progression beyond conventional diagnostic labels and clinical scores.

cs.LG

All in One: Generative Modeling as Mean-Field Game Design

Mean-field games (MFGs) offer a unifying lens on continuous-time generative modeling: a cost tuple recovering twelve prominent models---Continuous Normalizing Flows, OT-Flow, Score-based Models, Schr\"{o}dinger Bridges, and more---as special cases of one variational problem. Yet two dimensions of this space remain entirely unexplored: the interaction term $\mathcal{I}$ is set to zero in many existing models, and the rich family of MFG solvers has never been applied to generative modeling. We address both gaps with MFGLab an open-source PyTorch library whose primary API is the cost tuple: all twelve models are specified by four composable cost functions, and the training loop, log-Jacobian, and reverse-ODE sampler are shared automatically. We additionally propose DI-Flow, a novel cost design that uses a differentiable entropy functional to encourage mode coverage, and provide learning-based MFG solvers that substantially outperform neural training on stochastic-dynamics rows. Experiments on two 2-D benchmarks confirm that the unified API is lossless relative to hand-coded implementations.

cs.LG

Multi-Agent Privacy Game in Federated Learning: A Unified Mean-Field View

Federated learning enables collaborative model training across distributed clients without centralising their data, yet privacy remains a persistent concern because the shared model updates can leak information about local datasets. Existing privacy-preserving methods either inject calibrated noise into client updates, limiting their composition guarantees, or formulate client privacy choices as a multi-agent game whose Nash equilibrium becomes intractable as the number of clients grows. We bridge these two lines of work by formulating privacy-preserving federated learning as a mean-field privacy game: each client strategically chooses its own privacy budget while interacting with the population only through a single mean-field statistic. The mean-field limit yields a tractable equilibrium for arbitrarily many clients, accommodates heterogeneous client preferences, and inherits an exponentially decaying privacy guarantee through a log-Sobolev contraction. The framework recovers the entropic privacy baseline as the homogeneous special case and the multi-agent privacy game as the finite-population case. Experiments on quadratic regression, logistic regression, and MNIST demonstrate that the proposed framework attains the privacy-utility trade-off of the entropic baseline while delivering a personalized privacy guarantee that the homogeneous baseline cannot express.

cs.LG

How Does Urban Context Relate to Residential Building Health? A Vision-POI Fusion Framework for Building-Level Housing Inspection

Housing-level urban physical examination is essential for identifying residential building problems and supporting targeted urban renewal. Existing automated inspection studies primarily rely on individual images and rarely examine whether surrounding urban functional context can provide supplementary information for building-level assessment. This study proposes a vision-POI fusion framework that combines multi-view visual inspection with POI-derived neighborhood context for residential building health assessment. The empirical dataset covers 92 old residential communities, 3,237 residential buildings, and 25,608 field-acquired inspection images in Qingdao, China, encompassing seven categories of housing-related issues. First, multiple object detection models are evaluated to extract issue locations, categories, and confidence scores from individual images. The image-level outputs are subsequently aggregated across multiple views to construct interpretable building-level representations. Second, POI features are extracted within 500m, 1,000m, and 1,500m neighborhood buffers to characterize surrounding functional environments. Pearson and Spearman correlation analyses, combined with false discovery rate correction, are used to identify candidate contextual features. Finally, visual and POI features are integrated using a cost-sensitive Random Forest classifier under community-isolated spatial cross-validation. The results show that multi-view aggregation provides the main performance improvement, increasing the building-level Macro-F1 from 60.84% under Direct Detection to 74.95%. Incorporating POI context further increases Macro-F1 to 76.79%, although the additional gain is modest and category-dependent. POI information therefore functions as a supplementary contextual prior rather than a substitute for direct visual evidence or a causal determinant of building condition.

cs.CV

Stability of vertically charged steady magnetic field in 3D incompressible magneto-micropolar fluids without magnetic and angular viscosity in a strip domain

This paper intends to understand the regularity and stability problem on the 3D incompressible magneto-micropolar equations with zero magnetic and angular viscosities in a strip domain. The magneto-micropolar system models the electrically conducting micropolar fluid in the presence of a magnetic field. The lack of magnetic diffusion and angular dissipation makes it impossible to prove even small data global well-posedness result, let alone general large data global regularity. This paper presents a steady-state setup around which any perturbations can be shown to be globally regular and stable. More precisely, any small perturbation near a steady magnetic field perpendicular to the horizontal boundary leads to a unique global classical solution. In addition, the solution is shown to converge to the steady state at an almost exponential rate as time goes to infinity. These appear to be the very first rigorous global results on the magneto-micropolar equations concerned here.

math.AP

Artemis: Anatomy-Resolved inTervention for Eliminating Multimodal NeuroImage confounderS

Multimodal neuroimaging, integrating functional connectivity from fMRI and structural connectivity from DTI, enables non-invasive analysis of brain networks using graph neural networks. However, demographic factors such as age and sex systematically confound the relationship between brain connectivity and clinical outcomes, causing GNNs to exploit spurious shortcuts rather than learning causally invariant representations. While recent causal GNN methods introduce causality at the graph-modeling level, their causal mechanisms remain domain-agnostic without accounting for the real-world confounders inherent in clinical neuroimaging data. Moreover, brain networks are constructed from atlas-based parcellations where each region exhibits distinct sensitivity to demographic factors, necessitating region-aware adjustment. We propose Artemis, a region-level causal framework that bridges this gap with causal intervention at each brain region independently by learning region-specific confounder representations with lightweight parameters. Our adjustment comprehensively utilized the multimodal functional and structural features for graph reasoning as a plug-in module compatible with arbitrary GNN backbones. Experiments on three benchmarks, ADNI for disease diagnosis, OASIS for dementia staging, and HCP for sex classification, demonstrate consistent improvements over representative GNN-based baselines. Multiple supporting experiments further demonstrate statistical significance and neuroscientific interpretability.

cs.LG

Boundary symmetry breaking via logistic damping in a chemotaxis-growth system

We establish global stability for a chemotaxis-growth model with logarithmic sensitivity under dynamic Dirichlet boundary conditions on a 1D domain. We analyze both parabolic-parabolic and parabolic-hyperbolic systems. The key challenge is handling time-dependent boundary data for the unknown functions. We overcome this by introducing dynamic reference profiles which suitably interpolate boundary values. Using an expanded entropy functional measuring deviation from these profiles, we prove energy estimates the uniform boundedness of solutions and global asymptotic stability of perturbations.

math.AP

Listen, Look, Drive: Coupling Audio Instructions for User-aware VLA-based Autonomous Driving

Vision Language Action (VLA) models promise an open-vocabulary interface that can translate perceptual ambiguity into semantically grounded driving decisions, yet they still treat language as a static prior fixed at inference time. As a result, the model must infer continuously shifting objectives from pixels alone, yielding delayed or overly conservative maneuvers. We argue that effective VLAs for autonomous driving need an online channel in which users can influence driving with specific intentions. To this end, we present EchoVLA, a user-aware VLA that couples camera streams with in situ audio instructions. We augment the nuScenes dataset with temporally aligned, intent-specific speech commands generated by converting ego-motion descriptions into synthetic audios. Further, we compose emotional speech-trajectory pairs into a multimodal Chain-of-Thought (CoT) for fine-tuning a Multimodal Large Model (MLM) based on Qwen2.5-Omni. Specifically, we synthesize the audio-augmented dataset with different emotion types paired with corresponding driving behaviors, leveraging the emotional cues embedded in tone, pitch, and speech tempo to reflect varying user states, such as urgent or hesitant intentions, thus enabling our EchoVLA to interpret not only the semantic content but also the emotional context of audio commands for more nuanced and emotionally adaptive driving behavior. In open-loop benchmarks, our approach reduces the average L2 error by $59.4\%$ and the collision rate by $74.4\%$ compared to the baseline of vision-only perception. More experiments on nuScenes dataset validate that EchoVLA not only steers the trajectory through audio instructions, but also modulates driving behavior in response to the emotions detected in the user's speech.

eess.AS

FigEx2: Visual-Conditioned Panel Detection and Captioning for Scientific Compound Figures

Scientific compound figures combine multiple labeled panels into a single image, and downstream pretraining and retrieval require panel-aligned visual-text pairs. However, in a PubMed Central (PMC)-scale crawl of 346,567 compound figures, 16.3% have no caption and are discarded by existing caption-decomposition pipelines. We propose FigEx2, a visual-conditioned framework that takes only a compound figure as input and jointly produces labeled panel boxes and panel-wise captions. FigEx2 introduces an Entity-Attention Kullback-Leibler (KL) regularizer that aligns the detector's cross-attention with scientific entities annotated for each panel, providing a stable conditioning signal that also improves localization, and applies Group Relative Policy Optimization (GRPO) with a panel-level Entity-F1 reward to optimize scientific faithfulness. We curate BioSci-Fig-Cap for in-domain supervision and contribute physics and chemistry test suites for cross-disciplinary evaluation. FigEx2 achieves 0.751 mAP@0.5:0.95 on BioSci-Fig-Cap, and outperforms Qwen3-VL-8B by 6.80 Entity-F1 on MedICaT for captioning. It also transfers zero-shot to out-of-distribution domains. The source code is available at https://github.com/Huang-AI4Medicine-Lab/FigEx2.

cs.CV

HERO: Hierarchical Evidential Reasoning Optimization for Radiology Report Generation via Reason-then-Summarize

Multimodal Large Language Models (MLLMs) have substantially advanced Radiology Report Generation (RRG), yet aligning them through reinforcement learning (RL) remains challenging due to heterogeneous medical supervision. Vanilla Group Relative Policy Optimization (GRPO) assigns uniform credit across the entire generation, leading to segment interference, token dilution, and evidence--diagnosis decoupling, which exacerbates clinical hallucinations. We propose HERO (Hierarchical Evidential Reasoning Optimization), a factorized policy optimization framework that aligns heterogeneous supervision with three optimization granularities. HERO separately optimizes reasoning, diagnosis, and evidence grounding through complementary segment-, token-, and completion-level optimization with a heterogeneous reward formulation covering diagnostic accuracy, reasoning quality, and think--answer consistency. Experiments on MIMIC-CXR and IU-Xray show that HERO outperforms strong supervised and reinforcement learning baselines, achieving state-of-the-art clinical efficacy while producing more evidence-grounded and think--answer-consistent reports, thereby substantially mitigating clinical hallucinations.

cs.LG

Unveiling Explicit Patterns: Exact Steady States and Stability in a Confined Chemotaxis Model

Inspired by Carrillo-Li-Wang's work [Proc. London Math. Soc., 2021] on stationary solutions to the singular Keller-Segel system, this paper presents a novel family of explicit steady-state solutions for the same model on a bounded interval, expressed in terms of trigonometric and hyperbolic functions. Under Dirichlet boundary conditions and within a biologically stable parameter regime, these solutions, including singular types such as secant and cosecant, are rigorously derived and analyzed. Their stability is established via energy methods, yielding precise thresholds for pattern persistence. These results provide valuable benchmarks for numerical validation and offer insights into boundary-driven pattern formation.

math.AP

R-GenIMA: Integrating Neuroimaging and Genetics with Interpretable Multimodal AI for Alzheimer's Disease Progression

Early detection of Alzheimer's disease (AD) requires models capable of integrating macro-scale neuroanatomical alterations with micro-scale genetic susceptibility, yet existing multimodal approaches struggle to align these heterogeneous signals. We introduce R-GenIMA, an interpretable multimodal large language model that couples a novel ROI-wise vision transformer with genetic prompting to jointly model structural MRI and single nucleotide polymorphisms (SNPs) variations. By representing each anatomically parcellated brain region as a visual token and encoding SNP profiles as structured text, the framework enables cross-modal attention that links regional atrophy patterns to underlying genetic factors. Applied to the ADNI cohort, R-GenIMA achieves state-of-the-art performance in four-way classification across normal cognition (NC), subjective memory concerns (SMC), mild cognitive impairment (MCI), and AD. Beyond predictive accuracy, the model yields biologically meaningful explanations by identifying stage-specific brain regions and gene signatures, as well as coherent ROI-Gene association patterns across the disease continuum. Attention-based attribution revealed genes consistently enriched for established GWAS-supported AD risk loci, including APOE, BIN1, CLU, and RBFOX1. Stage-resolved neuroanatomical signatures identified shared vulnerability hubs across disease stages alongside stage-specific patterns: striatal involvement in subjective decline, frontotemporal engagement during prodromal impairment, and consolidated multimodal network disruption in AD. These results demonstrate that interpretable multimodal AI can synthesize imaging and genetics to reveal mechanistic insights, providing a foundation for clinically deployable tools that enable earlier risk stratification and inform precision therapeutic strategies in Alzheimer's disease.

cs.LG

Why Text Prevails: Vision May Undermine Multimodal Medical Decision Making

With the rapid progress of large language models (LLMs), advanced multimodal large language models (MLLMs) have demonstrated impressive zero-shot capabilities on vision-language tasks. In the biomedical domain, however, even state-of-the-art MLLMs struggle with basic Medical Decision Making (MDM) tasks. We investigate this limitation using two challenging datasets: (1) three-stage Alzheimer's disease (AD) classification (normal, mild cognitive impairment, dementia), where category differences are visually subtle, and (2) MIMIC-CXR chest radiograph classification with 14 non-mutually exclusive conditions. Our empirical study shows that text-only reasoning consistently outperforms vision-only or vision-text settings, with multimodal inputs often performing worse than text alone. To mitigate this, we explore three strategies: (1) in-context learning with reason-annotated exemplars, (2) vision captioning followed by text-only inference, and (3) few-shot fine-tuning of the vision tower with classification supervision. These findings reveal that current MLLMs lack grounded visual understanding and point to promising directions for improving multimodal decision making in healthcare.

cs.CV

Transformed $\ell_1$ Regularizations for Robust Principal Component Analysis: Toward a Fine-Grained Understanding

Robust Principal Component Analysis (RPCA) aims to recover a low-rank structure from noisy, partially observed data that is also corrupted by sparse, potentially large-magnitude outliers. Traditional RPCA models rely on convex relaxations, such as nuclear norm and $\ell_1$ norm, to approximate the rank of a matrix and the $\ell_0$ functional (the number of non-zero elements) of another. In this work, we advocate a nonconvex regularization method, referred to as transformed $\ell_1$ (TL1), to improve both approximations. The rationale is that by varying the internal parameter of TL1, its behavior asymptotically approaches either $\ell_0$ or $\ell_1$. Since the rank is equal to the number of non-zero singular values and the nuclear norm is defined as their sum, applying TL1 to the singular values can approximate either the rank or the nuclear norm, depending on its internal parameter. We conduct a fine-grained theoretical analysis of statistical convergence rates, measured in the Frobenius norm, for both the low-rank and sparse components under general sampling schemes. These rates are comparable to those of the classical RPCA model based on the nuclear norm and $\ell_1$ norm. Moreover, we establish constant-order upper bounds on the estimated rank of the low-rank component and the cardinality of the sparse component in the regime where TL1 behaves like $\ell_0$, assuming that the respective matrices are exactly low-rank and exactly sparse. Extensive numerical experiments on synthetic data and real-world applications demonstrate that the proposed approach achieves higher accuracy than the classic convex model, especially under non-uniform sampling schemes.

stat.ML

Blueprint First, Model Second: A Framework for Deterministic LLM Workflow

While powerful, the inherent non-determinism of large language model (LLM) agents limits their application in structured operational environments where procedural fidelity and predictable execution are strict requirements. This limitation stems from current architectures that conflate probabilistic, high-level planning with low-level action execution within a single generative process. To address this, we introduce the \textsc{Source Code Agent} framework, a new paradigm built on the ``Blueprint First, Model Second'' philosophy that decouples workflow logic from the generative model. An expert-defined operational procedure is first codified into a source code-based Execution Blueprint, which is then executed by a deterministic engine. The LLM is strategically invoked as a specialized tool to handle bounded, complex sub-tasks within the workflow, but never to decide the workflow's path. We evaluate on the TravelPlanner benchmark for constraint-aware travel planning. The \textsc{Source Code Agent} achieves a 35.56\% final pass rate, a 97.6\% improvement over the state-of-the-art ATLAS baseline (18.00\%) on the same Claude-Sonnet-4 backbone. Critically, it reduces constraint violations by 96.0\% (11 vs 275) while improving execution efficiency by 27.1\% (10.2$\pm$0.7 steps vs 14.0). Two production incident-diagnosis deployments and additional results on ScienceWorld and ALFWorld confirm that the architecture transfers beyond travel planning to procedurally well-defined, constraint-intensive workflows. Our work enables the verifiable and reliable deployment of autonomous agents in applications governed by strict procedural logic.

cs.SE

DRE: An Effective Dual-Refined Method for Integrating Small and Large Language Models in Open-Domain Dialogue Evaluation

Large Language Models (LLMs) excel at many tasks but struggle with ambiguous scenarios where multiple valid responses exist, often yielding unreliable results. Conversely, Small Language Models (SLMs) demonstrate robustness in such scenarios but are susceptible to misleading or adversarial inputs. We observed that LLMs handle negative examples effectively, while SLMs excel with positive examples. To leverage their complementary strengths, we introduce SLIDE (Small and Large Integrated for Dialogue Evaluation), a method integrating SLMs and LLMs via adaptive weighting. Building on SLIDE, we further propose a Dual-Refinement Evaluation (DRE) method to enhance SLM-LLM integration: (1) SLM-generated insights guide the LLM to produce initial evaluations; (2) SLM-derived adjustments refine the LLM's scores for improved accuracy. Experiments demonstrate that DRE outperforms existing methods, showing stronger alignment with human judgment across diverse benchmarks. This work illustrates how combining small and large models can yield more reliable evaluation tools, particularly for open-ended tasks such as dialogue evaluation.

cs.CL

Pattern formation in a vasculogenesis model

This paper investigates steady state solutions of a vasculogenesis model governed by coupled partial differential equations in a bounded two dimensional domain. Explicit steady state solutions are analytically constructed, and their stability is rigorously analyzed under prescribed initial and boundary conditions. By employing energy method, we prove that these solutions exhibit local asymptotic stability when specific parametric criteria are satisfied. The analysis establishes a direct connection between the stability thresholds and the system's diffusion coefficient, offering quantitative insights into the mechanisms governing pattern formation. These results provide foundational theoretical advances for understanding self organization in chemotaxis driven biological systems, particularly vasculogenesis.

math.AP