Kunkun Zhang | Searcharxiv

arXiv2026

Cross-Anesthetic ECoG State Decoding Fails at the Decision Threshold, Not the Representation

Decoders of anesthetic state from cortical activity fail across drug classes, most notoriously ketamine, but reported accuracy cannot say whether the neural representation or only the decision threshold has failed; we separate the two in a controlled preparation with ground-truth labels. We decoded awake versus anesthetized from mouse electrocorticography (the 250-Hz-bandlimited local field potential, sampled at 1875 Hz) under leave-one-anesthetic-out evaluation across five mechanistically distinct anesthetics (isoflurane, dexmedetomidine, ketamine, propofol, and midazolam), comparing a spatially blind band-power decoder, covariance/Riemannian representations, and Riemannian domain adaptation, with all statistics at the session level and mouse-level cluster bootstrapping for the ketamine fold. The representation transfers: band-power ranks awake versus anesthetized at a session AUROC of at least 0.96 on every held-out drug, ketamine included (0.980, cluster confidence interval 0.821 to 1.000). The failure is confined to the threshold: across three representations the ketamine ranking is near-invariant while its balanced accuracy swings from chance to high, and a permutation test is significant for ranking (p = 0.0025) but not for fixed-threshold accuracy (p = 0.3795). Riemannian domain adaptation is net-negative. A causal, label-free threshold anchored to the subject's own pre-induction baseline fixes ketamine (balanced accuracy 0.50 to 0.85) and dominates domain adaptation. Because the ketamine test sessions come from three mice that also contribute training drugs, this is within-subject cross-drug transfer; we do not claim population-level transfer across subjects. In cross-drug state decoding the actionable failure is calibration, not representation.

q-bio.QM↗

arXiv2023

Decentralized Local Updates with Dual-Slow Estimation and Momentum-based Variance-Reduction for Non-Convex Optimization

Decentralized learning (DL) has recently employed local updates to reduce the communication cost for general non-convex optimization problems. Specifically, local updates require each node to perform multiple update steps on the parameters of the local model before communicating with others. However, most existing methods could be highly sensitive to data heterogeneity (i.e., non-iid data distribution) and adversely affected by the stochastic gradient noise. In this paper, we propose DSE-MVR to address these problems.Specifically, DSE-MVR introduces a dual-slow estimation strategy that utilizes the gradient tracking technique to estimate the global accumulated update direction for handling the data heterogeneity problem; also for stochastic noise, the method uses the mini-batch momentum-based variance-reduction technique.We theoretically prove that DSE-MVR can achieve optimal convergence results for general non-convex optimization in both iid and non-iid data distribution settings. In particular, the leading terms in the convergence rates derived by DSE-MVR are independent of the stochastic noise for large-batches or large partial average intervals (i.e., the number of local update steps). Further, we put forward DSE-SGD and theoretically justify the importance of the dual-slow estimation strategy in the data heterogeneity setting. Finally, we conduct extensive experiments to show the superiority of DSE-MVR against other state-of-the-art approaches.

cs.DC↗