arXiv subjects

Kyle Lam

Publications and source records attributed to Kyle Lam.

10 recordsLinked to original sources

arXiv2026

CaseWeaver: A Multi-Agent Framework for Multimodal Virtual Clinical Case Generation

Clinical diagnosis relies on consistent multimodal data collected from the same patient throughout the disease course, yet such data are difficult to acquire at scale because of collection costs, missing modalities, fragmented systems, and longitudinal follow-ups. Existing synthetic-data approaches largely focus on individual modalities or vision-language dual modalities at report-level generation. Little work has been done to construct synthetic data with consistent patient backgrounds, coherent disease trajectories, and interrelated modality-specific evidence at a complete clinical case level. We introduce CaseWeaver, a multi-agent framework built around a timeline-anchored Latent Clinical Case Graph (LCCG). The LCCG organizes patient context, latent disease states, clinical events, and expected observations in a shared patient-level representation. Modality-agents use scoped observation subgraphs and clinical protocols to generate evidence including clinical records, laboratory results, physiological signals, and medical images. We evaluate clinical inferability using a calibrated AgentClinic protocol and case diversity using Virtual Case Diversity (VCD) score. CaseWeaver outperformed general-model and agentic-workflow baselines on both metrics, producing more diverse and coherent multimodal virtual clinical cases.

cs.MA↗

arXiv2026

MEDSYN: Benchmarking Multi-EviDence SYNthesis in Complex Clinical Cases for Multimodal Large Language Models

Multimodal large language models (MLLMs) have shown great potential in medical applications, yet existing benchmarks inadequately capture real-world clinical complexity. We introduce MEDSYN, a multilingual, multimodal benchmark of highly complex clinical cases with up to 7 distinct visual clinical evidence (CE) types per case. Mirroring clinical workflow, we evaluate 18 MLLMs on differential diagnosis (DDx) generation and final diagnosis (FDx) selection. While top models often match or even outperform human experts on DDx generation, all MLLMs exhibit a much larger DDx--FDx performance gap compared to expert clinicians, indicating a failure mode in synthesis of heterogeneous CE types. Ablations attribute this failure to (i) overreliance on less discriminative textual CE ($\it{e.g.}$, medical history) and (ii) a cross-modal CE utilization gap. We introduce Evidence Sensitivity to quantify the latter and show that a smaller gap correlates with higher diagnostic accuracy. Finally, we demonstrate how it can be used to guide interventions to improve model performance. We will open-source our benchmark and code.

cs.CL↗

arXiv2025

Recognizing Pneumonia in Real-World Chest X-rays with a Classifier Trained with Images Synthetically Generated by Nano Banana

We trained a classifier with synthetic chest X-ray (CXR) images generated by Nano Banana, the latest AI model for image generation and editing, released by Google. When directly applied to real-world CXRs having only been trained with synthetic data, the classifier achieved an AUROC of 0.923 (95% CI: 0.919 - 0.927), and an AUPR of 0.900 (95% CI: 0.894 - 0.907) in recognizing pneumonia in the 2018 RSNA Pneumonia Detection dataset (14,863 CXRs), and an AUROC of 0.824 (95% CI: 0.810 - 0.836), and an AUPR of 0.913 (95% CI: 0.904 - 0.922) in the Chest X-Ray dataset (5,856 CXRs). These external validation results on real-world data demonstrate the feasibility of this approach and suggest potential for synthetic data in medical AI development. Nonetheless, several limitations remain at present, including challenges in prompt design for controlling the diversity of synthetic CXR data and the requirement for post-processing to ensure alignment with real-world data. However, the growing sophistication and accessibility of medical intelligence will necessitate substantial validation, regulatory approval, and ethical oversight prior to clinical translation.

cs.CV↗

arXiv2025

Current validation practice undermines surgical AI development

Surgical data science (SDS) is rapidly advancing, yet clinical adoption of artificial intelligence (AI) in surgery remains limited, with inadequate validation as an important contributing factor. Existing validation practices often neglect the temporal and hierarchical structure of intraoperative videos, yielding misleading or clinically irrelevant results. We introduce a comprehensive catalogue of validation pitfalls in AI-based surgical video analysis, derived from a multi-stage Delphi process with 92 international experts. Pitfalls span three categories: (1) data, (2) metric selection/configuration, and (3) aggregation and reporting. A systematic review of surgical AI papers reveals that these pitfalls are widespread. Experiments on surgical video datasets show that ignoring temporal and hierarchical data structures can understate uncertainty, obscure critical failure modes, and alter algorithm rankings. To address these shortcomings, we provide consensus-based best practices compiled. Together, this work provides an evidence-based framework for rigorous validation of surgical video analysis algorithms, guiding benchmarking, reporting, regulatory review, and clinical translation.

q-bio.OT↗

arXiv2025

Emerging Cyber Attack Risks of Medical AI Agents

Large language models (LLMs)-powered AI agents exhibit a high level of autonomy in addressing medical and healthcare challenges. With the ability to access various tools, they can operate within an open-ended action space. However, with the increase in autonomy and ability, unforeseen risks also arise. In this work, we investigated one particular risk, i.e., cyber attack vulnerability of medical AI agents, as agents have access to the Internet through web browsing tools. We revealed that through adversarial prompts embedded on webpages, cyberattackers can: i) inject false information into the agent's response; ii) they can force the agent to manipulate recommendation (e.g., healthcare products and services); iii) the attacker can also steal historical conversations between the user and agent, resulting in the leak of sensitive/private medical information; iv) furthermore, the targeted agent can also cause a computer system hijack by returning a malicious URL in its response. Different backbone LLMs were examined, and we found such cyber attacks can succeed in agents powered by most mainstream LLMs, with the reasoning models such as DeepSeek-R1 being the most vulnerable.

cs.CR↗

arXiv2025

The Local Galactic Transient Survey Applied to an Optical Search for Directed Intelligence

We discuss our transient search for directed energy systems in local galaxies, with calculations indicating the ability of modest searches to detect optical Search for Extraterrestrial Intelligence (SETI) sources in the closest galaxies. Our analysis follows Lubin (2016) where a messenger civilization follows a beacon strategy we call "intelligent targeting." We plot the required laser time to achieve an SNR of 10 and find the time for a blind transmission to target all stars in the Milky Way to be achievable for local galactic civilizations. As high cadence and sky coverage is the pathway to enable such a detection, we operate the Local Galactic Transient Survey (LGTS) targeting M31 (the Andromeda Galaxy), the Large Magellanic Cloud (LMC), and the Small Magellanic Cloud (SMC) via Las Cumbres Observatory's (LCO) network of 0.4 m telescopes. We explore the ability of modest searches like the LGTS to detect directed pulses in optical and near-infrared wavelengths from Extraterrestrial Intelligence (ETI) at these distances and conclude a civilization utilizing less powerful laser technology than we can construct in this century is readily detectable with the LGTS's observational capabilities. Data processing of 30,000 LGTS images spanning 5 years is in progress with the TRansient Image Processing Pipeline (TRIPP; Thomas et al. (2025)).

astro-ph.IM↗

arXiv2025

TRIPP: A General Purpose Data Pipeline for Astronomical Image Processing

We present the TRansient Image Processing Pipeline (TRIPP), a transient and variable source detection pipeline that employs both difference imaging and light curve analysis techniques for astronomical data. Additionally, we demonstrate TRIPP's rapid analysis capability by detecting transient candidates in near-real time. TRIPP was tested using image data of the supernova SN2023ixf and from the Local Galactic Transient Survey (LGTS, Thomas et al. (2025)) collected by the Las Cumbres Observatory's (LCO) network of 0.4 m telescopes. To verify the methods employed by TRIPP, we compare our results to published findings on the photometry of SN2023ixf. Additionally, we report the ability of TRIPP to detect transient signals from optical Search for Extra Terrestrial Intelligence (SETI) sources.

astro-ph.IM↗

arXiv2024

Compound Mutations in the Abl1 Kinase Cause Inhibitor Resistance by Shifting DFG Flip Mechanisms and Relative State Populations

The intrinsic dynamics of most proteins are central to their function. Protein tyrosine kinases such as Abl1 undergo significant conformational changes that modulate their activity in response to different stimuli. These conformational changes constitute a conserved mechanism for self-regulation that dramatically impacts kinases' affinities for inhibitors. Few studies have attempted to extensively sample the pathways and elucidate the mechanisms that underlie kinase inactivation. Seeking to bridge this knowledge gap, we present a thorough analysis of the ``DFG flip'' inactivation pathway in Abl1 kinase. By leveraging the power of the Weighted Ensemble methodology, which accelerates sampling without the use of biasing forces, we have comprehensively simulated DFG flip events in Abl1 and its inhibitor-resistant variants, revealing a rugged landscape punctuated by potentially druggable intermediate states. Through our strategy, we successfully simulated dozens of uncorrelated DFG flip events distributed along two principal pathways, identified the molecular mechanisms that govern them, and measured their relative probabilities. Further, we show that the compound Glu255Lys/Val Thr315Ile Abl1 variants owe their inhibitor resistance phenotype to an increase in the free energy barrier associated with completing the DFG flip. This barrier stabilizes Abl1 variants in conformations that can lead to loss of binding for Type-II inhibitors such as Imatinib or Ponatinib. Finally, we contrast our Abl1 observations with the relative state distributions and propensity for undergoing a DFG flip of evolutionarily-related protein tyrosine kinases with diverging Type-II inhibitor binding affinities. Altogether, we expect that our work will be of significant importance for protein tyrosine kinase inhibitor discovery.

physics.bio-ph↗

arXiv2023

Large AI Models in Health Informatics: Applications, Challenges, and the Future

Large AI models, or foundation models, are models recently emerging with massive scales both parameter-wise and data-wise, the magnitudes of which can reach beyond billions. Once pretrained, large AI models demonstrate impressive performance in various downstream tasks. A prime example is ChatGPT, whose capability has compelled people's imagination about the far-reaching influence that large AI models can have and their potential to transform different domains of our lives. In health informatics, the advent of large AI models has brought new paradigms for the design of methodologies. The scale of multi-modal data in the biomedical and health domain has been ever-expanding especially since the community embraced the era of deep learning, which provides the ground to develop, validate, and advance large AI models for breakthroughs in health-related areas. This article presents a comprehensive review of large AI models, from background to their applications. We identify seven key sectors in which large AI models are applicable and might have substantial influence, including 1) bioinformatics; 2) medical diagnosis; 3) medical imaging; 4) medical informatics; 5) medical education; 6) public health; and 7) medical robotics. We examine their challenges, followed by a critical discussion about potential future directions and pitfalls of large AI models in transforming the field of health informatics.

cs.AI↗

arXiv2020

Surgical Data Science -- from Concepts toward Clinical Translation

Recent developments in data science in general and machine learning in particular have transformed the way experts envision the future of surgery. Surgical Data Science (SDS) is a new research field that aims to improve the quality of interventional healthcare through the capture, organization, analysis and modeling of data. While an increasing number of data-driven approaches and clinical applications have been studied in the fields of radiological and clinical data science, translational success stories are still lacking in surgery. In this publication, we shed light on the underlying reasons and provide a roadmap for future advances in the field. Based on an international workshop involving leading researchers in the field of SDS, we review current practice, key achievements and initiatives as well as available standards and tools for a number of topics relevant to the field, namely (1) infrastructure for data acquisition, storage and access in the presence of regulatory constraints, (2) data annotation and sharing and (3) data analytics. We further complement this technical perspective with (4) a review of currently available SDS products and the translational progress from academia and (5) a roadmap for faster clinical translation and exploitation of the full potential of SDS, based on an international multi-round Delphi process.

cs.CY↗