arXiv subjects

Kyongtae Tyler Bae

Publications and source records attributed to Kyongtae Tyler Bae.

3 recordsLinked to original sources

arXiv2026

Controllable Diffusion-Based Lesion Inpainting for Scalable Histopathology Data Augmentation

Expert-annotated training data remains the critical bottleneck for AI in histopathology, particularly for rare pathologies where even dozens of cases may be unavailable. While data augmentation offers a solution, existing methods fail to generate sufficiently realistic lesion morphologies that preserve tissue-specific architectures. Here we present PathoGen, a diffusion-based generative model enabling controllable, high-fidelity lesion inpainting into benign histopathology images. We validate PathoGen across four datasets representing kidney, skin, breast, and prostate pathology. Quantitative assessment confirms PathoGen outperforms state-of-the-art baselines in image fidelity and distributional similarity. Evaluation by six expert pathologists revealed that synthetic images by PathoGen were only marginally distinguished from real tissue image slightly above chance (57.75% accuracy), demonstrating strong perceptual realism of PathoGen-generated lesions. PathoGen achieved the highest win rate (35.4%) when pathologists ranked generation quality against all baselines. Crucially, augmenting training sets with PathoGen-synthesized lesions improves segmentation Dice scores by up to 0.18 compared to traditional augmentations, with maximum benefit in data-scarce regimes. By simultaneously generating realistic morphology and pixel-level annotations, PathoGen effectively addresses both data scarcity and annotation cost, two critical bottlenecks in computational pathology development.

cs.CV↗

arXiv2026

ChemCLIP: Bridging Organic and Inorganic Anticancer Compounds Through Contrastive Learning

The discovery of anticancer therapeutics has traditionally treated organic small molecules and metal-based coordination complexes as separate chemical domains, limiting knowledge transfer despite their shared biological objectives. This disparity is particularly pronounced in available data, with extensive screening databases for organic compounds compared to only a few thousand characterized metal complexes. Here, we introduce ChemCLIP, a dual-encoder contrastive learning framework that bridges this organic-inorganic divide by learning unified representations based on shared anticancer activities rather than structural similarity. We compiled complementary datasets comprising 44,854 unique organic compounds and 5,164 unique metal complexes, standardized across 60 cancer cell lines. By training parallel encoders with activity-aware hard negative mining, we mapped structurally distinct compounds into a shared 256-dimensional embedding space where biologically similar compounds cluster together regardless of chemical class. We systematically evaluated four molecular encoding strategies: Morgan fingerprints, ChemBERTa, MolFormer, and Chemprop, through quantitative alignment metrics, embedding visualizations, and downstream classification tasks. Morgan fingerprints achieved superior performance with an average alignment ratio of 0.899 and downstream classification AUCs of 0.859 (inorganic) and 0.817 (organic). This work establishes contrastive learning as an effective strategy for unifying disparate chemical domains and provides empirical guidance for encoder selection in multi-modal chemistry applications, with implications extending beyond anticancer drug discovery to any scenario requiring cross-domain chemical knowledge transfer.

cs.LG↗

arXiv2024

AutoPET III Challenge: PET/CT Semantic Segmentation

In this study, we implemented a two-stage deep learning-based approach to segment lesions in PET/CT images for the AutoPET III challenge. The first stage utilized a DynUNet model for coarse segmentation, identifying broad regions of interest. The second stage refined this segmentation using an ensemble of SwinUNETR, SegResNet, and UNet models. Preprocessing involved resampling images to a common resolution and normalization, while data augmentation techniques such as affine transformations and intensity adjustments were applied to enhance model generalization. The dataset was split into 80% training and 20% validation, excluding healthy cases. This method leverages multi-stage segmentation and model ensembling to achieve precise lesion segmentation, aiming to improve robustness and overall performance.

eess.IV↗