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L. Campo-Deaño

Publications and source records attributed to L. Campo-Deaño.

4 recordsLinked to original sources

Magnetorheological Characterization of Blood Analogues Seeded with Paramagnetic Particles

Magnetic particle under external fields can be useful in various medical applications, gaining access to the whole body if deployed in the bloodstream. Localised drug delivery, haemorrhage control, and cancer treatment are among the applications that have the potential to become revolutionary therapies. Despite this interest, a magnetorheological characterisation of particle-seeded blood has yet to be achieved. In this work, we evaluate the magnetorheological response of blood analogues seeded with paramagnetic particles in different concentrations, under the effects of a uniform, density-varying magnetic field. Through steady shear experiments, we encounter the usual magnetically-induced shear thinning response, and oscillatory shear results point toward significant alterations in the fluids' microstructure. However, experimental limitations make it difficult to accurately evaluate the oscillatory shear response of such rheologically subtle fluids, limiting both the quality and quantity of achievable information. Despite experimental limitations, our results demonstrate that magnetic fields can induce marked and quantifiable rheological changes in seeded blood analogues. The framework established here provides a foundation for future studies on real blood samples and for the design of magnetically responsive biomedical systems.

physics.flu-dyn↗

Pressure shifts in pulsatile shear: A microfluidic method to probe the normal stress response of complex fluids

A microfluidic approach to probing the first normal stress difference from single-point pressure measurements in transient shear flows is presented. Using an original experimental design, we examine the near-zero-mean pulsatile flow of polymeric solutions in a straight microchannel at low Reynolds and Womersley numbers. An important aspect of this work is that the enhanced fluid elastic stresses can be efficiently determined via the pressure shift measured from pressure-controlled pulsatile shear experiments. We find a scaling law that collapses pressure-shift data from viscoelastic fluids of different molecular weights onto a single master curve that can then be used to predict this phenomenology. Taken together, these results could help shed light on our understanding of the non-linear normal stress responses in time-dependent flows.

physics.flu-dyn↗

Effects of non-parallelism on standard and magnetorheological measurements

Aiming towards the magnetorheological characterisation of whole human blood, we evaluated the suitability of our experimental setup for steady shear measurements with low-viscosity fluids. Previous measurements with a rotational rheometer equipped with a magnetorheological cell returned low and inconsistent apparent-viscosity values. In this work, a parametric study was conducted, experimentally and numerically, to evaluate the possible error sources and define an experimentally reliable window. Steady shear measurements were carried out with Newtonian fluids using two geometries: parallel-plates at different gap heights, and cone-plate. A clear decrease in measured viscosity with parallel-plate gap reduction was found, along with a slight overestimation of the cone-plate. Numerical results corroborated the experimental observations, pointing towards a small inclination of the bottom plate (between 0.1° and 0.3°). The numerical study has also shown that geometry non-parallelism can lead to significant flow alterations, particularly for cone-plate geometries where contraction/expansion flow can be generated, critically deviating from the canonical Couette flow and provoking non-negligible errors. Additional experimental and numerical work was conducted to evaluate the effects of the non-parallelism on magnetorheological measurements. The geometrical asymmetry results in severe alterations of the microstructural dynamics, possibly leading to an underestimation of the magnetorheological response. This work has shown that geometry non-parallelism can have critical repercussions on simple shear flows, with fundamentally different implications from a general gap-error, and can be identified through comparative measurements with Newtonian fluids in different geometries (parallel-plates and cone-plate)

physics.flu-dyn↗

On flow disturbances caused by pressure taps in highly elastic flows around a microfluidic cylinder

The objective of this work is to characterise the onset of laterally asymmetric flow of viscoelastic solutions around a confined microfluidic cylinder, which was encountered in a recent study [Rodrigues et al., $\textit{J. Non-Newton. Fluid Mech.}$ $\textbf{289}$, 104406 (2020)]. To this end, two non-Newtonian fluids were employed in the same micro-geometry. Two microchannels were studied, both with a cylinder of diameter 75 $\mathrmμ$m, aspect ratio (channel height over width) of 0.37 and blockage ratio (cylinder diameter over channel width) of 0.28, differing only on the width of the pressure taps, located 500 $\mathrmμ$m up- and downstream from the respective cylinder face, on opposing walls. The working fluids consist of two poly(ethylene oxide) (PEO) solutions: a weakly shear-thinning elastic fluid and an elastic shear-thinning fluid. Micro-Particle Image Velocimetry ($\mathrmμ$PIV) and streak imaging techniques were used to evaluate the flow over a Weissenberg number range: $100\leq Wi\leq500$, while maintaining a low Reynolds number, $Re<1$. The elastic shear-thinning solution showed laterally asymmetric flow past the cylinder with both pressure tap designs, while with the weakly shear-thinning solution asymmetric flow was only observed with the wider pressure tap intake. In both cases, the fluids preferentially chose the cylinder/wall gap opposing the upstream pressure tap, which was found to influence the flow greatly, seemingly associated with time-dependent flow and possibly the lateral flow asymmetry itself. This work brings to light the necessary compromise between optimal pressure tap design for quality pressure measurements and minimal flow interference, due to the increased susceptibility of elastic microfluidic flows to flow perturbations.

physics.flu-dyn↗