arXiv subjects

L. Julián Lechuga López

Publications and source records attributed to L. Julián Lechuga López.

4 recordsLinked to original sources

arXiv2026

Data-Driven Priors for Uncertainty-Aware Risk Prediction of Clinical Deterioration using Multimodal Data

Safe predictions are a crucial requirement for integrating predictive models into clinical decision support systems. One approach to improving trustworthiness is to enable models to express uncertainty about individual predictions. However, current machine learning models frequently lack reliable uncertainty estimation, hindering real-world deployment. This limitation is particularly evident in multimodal settings, where models must effectively integrate heterogeneous information. In this work, we propose MedCertAIn, a predictive uncertainty framework that leverages multimodal clinical data to improve model performance and reliability for in-hospital mortality risk prediction as an indicator of patient deterioration. We design data-driven priors over neural network parameters using a hybrid strategy that considers cross-modal similarity in self-supervised latent representations and modality-specific data corruptions. We train and evaluate the models with such priors using clinical time-series and chest X-ray images from the publicly available datasets MIMIC-IV and MIMIC-CXR. Our results show that MedCertAIn achieves competitive predictive performance and substantial gains in selective prediction compared with the evaluated deterministic and stochastic baselines. These findings highlight the promise of data-driven priors in advancing robust, uncertainty-aware AI tools for high-stakes clinical applications. Our implementation is publicly available at: https://github.com/jlaitue/medcertain.

cs.LG↗

arXiv2026

An Empirical Analysis of Calibration and Selective Prediction in Multimodal Clinical Condition Classification

As artificial intelligence systems move toward clinical deployment, ensuring reliable prediction behavior is fundamental for safety-critical decision-making tasks. One proposed safeguard is selective prediction, where models can defer uncertain predictions to human experts for review. In this work, we empirically evaluate the reliability of uncertainty-based selective prediction in multilabel clinical condition classification using multimodal ICU data. Across a range of state-of-the-art unimodal and multimodal models, we find that selective prediction can substantially degrade performance despite strong standard evaluation metrics. This failure is driven by severe class-dependent miscalibration, whereby models assign high uncertainty to correct predictions and low uncertainty to incorrect ones, particularly for underrepresented clinical conditions. Our results show that commonly used aggregate metrics can obscure these effects, limiting their ability to assess selective prediction behavior in this setting. Taken together, our findings characterize a task-specific failure mode of selective prediction in multimodal clinical condition classification and highlight the need for calibration-aware evaluation to provide strong guarantees of safety and robustness in clinical AI.

cs.LG↗

arXiv2026

The Invisibility Hypothesis: Promises of AGI and the Future of the Global South

Discussions surrounding Artificial General Intelligence have largely focused on technical feasibility, timelines, and existential risk, often treating its social impact as being the same across different populations. Less attention has been paid to how advanced AI systems may interact with existing global inequalities. This paper examines the implications of AGI for people in the Global South, arguing that the availability of highly autonomous, general-purpose cognitive systems does not guarantee equitable outcomes. We establish that, as scientific discovery, economic coordination, and governance become increasingly automated, the relevance of human individuals may become conditional on access to infrastructure, institutional inclusion, and geopolitical circumstances rather than skills or intelligence. Under this setting, the Global South faces different pathways: in the best case, geographic location is no longer relevant as AGI fully democratizes access to knowledge and essential services for everyone in the globe; in the worst case, existing structural constraints are severely amplified, rendering already marginalized populations not merely economically invisible, but functionally irrelevant to global systems. We ground this analysis in empirical signals from contemporary AI deployment and extend to potential trajectories, highlighting both risk and opportunity pathways for Latin America, Africa, and South Asia.

cs.CY↗

arXiv2025

Uncertainty Quantification for Machine Learning in Healthcare: A Survey

Uncertainty Quantification (UQ) is pivotal in enhancing the robustness, reliability, and interpretability of Machine Learning (ML) systems for healthcare, optimizing resources and improving patient care. Despite the emergence of ML-based clinical decision support tools, the lack of principled quantification of uncertainty in ML models remains a major challenge. Current reviews have a narrow focus on analyzing the state-of-the-art UQ in specific healthcare domains without systematically evaluating method efficacy across different stages of model development, and despite a growing body of research, its implementation in healthcare applications remains limited. Therefore, in this survey, we provide a comprehensive analysis of current UQ in healthcare, offering an informed framework that highlights how different methods can be integrated into each stage of the ML pipeline including data processing, training and evaluation. We also highlight the most popular methods used in healthcare and novel approaches from other domains that hold potential for future adoption in the medical context. We expect this study will provide a clear overview of the challenges and opportunities of implementing UQ in the ML pipeline for healthcare, guiding researchers and practitioners in selecting suitable techniques to enhance the reliability, safety and trust from patients and clinicians on ML-driven healthcare solutions.

cs.LG↗