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L. Mosca

Publications and source records attributed to L. Mosca.

At least 19 recordsLinked to original sources
arXiv2022

Halting hyaluronidase activity with hyaluronan-based nanohydrogels: development of versatile injectable formulations

Hyaluronan (HA) is among the most used biopolymers for viscosupplementation and cosmetic applications. However, the current injectable HA-based formulations present relevant limitations: I) unmodified HA is quickly degraded by endogenous hyaluronidases (HAase), resulting in short lasting properties; II) cross-linked HA, although shows enhanced stability against HAase, often contains toxic chemical cross-linkers. As such, herein, we present biocompatible self-assembled hyaluronan-cholesterol nanohydrogels (HA-CH NHs) able to bind to HAase and inhibit the enzyme activity in vitro, more efficiently than currently marketed HA-based cross-linked formulations (e.g. JonexaTM). HA-CH NHs inhibit HAase through a mixed mechanism, by which NHs bind to HAase with an affinity constant 7-fold higher than that of HA. Similar NHs, based on gellan-cholesterol, evidenced no binding to HAase, neither inhibition of the enzyme activity, suggesting this effect might be due to the specific binding of HA-CH to the active site of the enzyme. Therefore, HA-CH NHs were engineered into injectable hybrid HA mixtures or physical hydrogels, able to halt the enzymatic degradation of HA.

cond-mat.soft↗
arXiv2013

A Very Intense Neutrino Super Beam Experiment for Leptonic CP Violation Discovery based on the European Spallation Source Linac: A Snowmass 2013 White Paper

Very intense neutrino beams and large neutrino detectors will be needed in order to enable the discovery of CP violation in the leptonic sector. We propose to use the proton linac of the European Spallation Source currently under construction in Lund, Sweden to deliver, in parallel with the spallation neutron production, a very intense, cost effective and high performance neutrino beam. The baseline program for the European Spallation Source linac is that it will be fully operational at 5 MW average power by 2022, producing 2 GeV 2.86 ms long proton pulses at a rate of 14 Hz. Our proposal is to upgrade the linac to 10 MW average power and 28 Hz, producing 14 pulses/s for neutron production and 14 pulses/s for neutrino production. Furthermore, because of the high current required in the pulsed neutrino horn, the length of the pulses used for neutrino production needs to be compressed to a few $μ$s with the aid of an accumulator ring. A long baseline experiment using this Super Beam and a megaton underground Water Cherenkov detector located in existing mines 300-600 km from Lund will make it possible to discover leptonic CP violation at 5 $σ$ significance level in up to 50% of the leptonic Dirac CP-violating phase range. This experiment could also determine the neutrino mass hierarchy at a significance level of more than 3 $σ$ if this issue will not already have been settled by other experiments by then. The mass hierarchy performance could be increased by combining the neutrino beam results with those obtained from atmospheric neutrinos detected by the same large volume detector. This detector will also be used to measure the proton lifetime, detect cosmological neutrinos and neutrinos from supernova explosions. Results on the sensitivity to leptonic CP violation and the neutrino mass hierarchy are presented.

hep-ex↗
arXiv2013

Future large-scale water-Cherenkov detector

MEMPHYS (MEgaton Mass PHYSics) is a proposed large-scale water-Cherenkov experiment to be performed deep underground. It is dedicated to nucleon decay searches and the detection of neutrinos from supernovae, solar, and atmospheric neutrinos, as well as neutrinos from a future beam to measure the CP violating phase in the leptonic sector and the mass hierarchy. This paper provides an overview of the latest studies on the expected performance of MEMPHYS in view of detailed estimates of its physics reach, mainly concerning neutrino beams.

physics.ins-det↗
arXiv2013

Study of the performance of a large scale water-Cherenkov detector (MEMPHYS)

MEMPHYS (MEgaton Mass PHYSics) is a proposed large-scale water Cherenkov experiment to be performed deep underground. It is dedicated to nucleon decay searches, neutrinos from supernovae, solar and atmospheric neutrinos, as well as neutrinos from a future Super-Beam or Beta-Beam to measure the CP violating phase in the leptonic sector and the mass hierarchy. A full simulation of the detector has been performed to evaluate its performance for beam physics. The results are given in terms of "Migration Matrices" of reconstructed versus true neutrino energy, taking into account all the experimental effects.

hep-ex↗
arXiv2009

The LAGUNA design study- towards giant liquid based underground detectors for neutrino physics and astrophysics and proton decay searches

The feasibility of a next generation neutrino observatory in Europe is being considered within the LAGUNA design study. To accommodate giant neutrino detectors and shield them from cosmic rays, a new very large underground infrastructure is required. Seven potential candidate sites in different parts of Europe and at several distances from CERN are being studied: Boulby (UK), Canfranc (Spain), Fréjus (France/Italy), Pyhäsalmi (Finland), Polkowice-Sieroszowice (Poland), Slanic (Romania) and Umbria (Italy). The design study aims at the comprehensive and coordinated technical assessment of each site, at a coherent cost estimation, and at a prioritization of the sites within the summer 2010.

physics.ins-det↗
arXiv2007

Large underground, liquid based detectors for astro-particle physics in Europe: scientific case and prospects

This document reports on a series of experimental and theoretical studies conducted to assess the astro-particle physics potential of three future large-scale particle detectors proposed in Europe as next generation underground observatories. The proposed apparatus employ three different and, to some extent, complementary detection techniques: GLACIER (liquid Argon TPC), LENA (liquid scintillator) and MEMPHYS (\WC), based on the use of large mass of liquids as active detection media. The results of these studies are presented along with a critical discussion of the performance attainable by the three proposed approaches coupled to existing or planned underground laboratories, in relation to open and outstanding physics issues such as the search for matter instability, the detection of astrophysical- and geo-neutrinos and to the possible use of these detectors in future high-intensity neutrino beams.

hep-ph↗
arXiv2007

Identification of backgrounds in the EDELWEISS-I dark matter search experiment

This paper presents our interpretation and understanding of the different backgrounds in the EDELWEISS-I data sets. We analyze in detail the several populations observed, which include gammas, alphas, neutrons, thermal sensor events and surface events, and try to combine all data sets to provide a coherent picture of the nature and localisation of the background sources. In light of this interpretation, we draw conclusions regarding the background suppression scheme for the EDELWEISS-II phase.

astro-ph↗
arXiv2006

Measurement of the response of heat-and-ionization germanium detectors to nuclear recoils

The heat quenching factor Q' (the ratio of the heat signals produced by nuclear and electron recoils of equal energy) of the heat-and-ionization germanium bolometers used by the EDELWEISS collaboration has been measured. It is explained how this factor affects the energy scale and the effective quenching factor observed in calibrations with neutron sources. This effective quenching effect is found to be equal to Q/Q', where Q is the quenching factor of the ionization yield. To measure Q', a precise EDELWEISS measurement of Q/Q' is combined with values of Q obtained from a review of all available measurements of this quantity in tagged neutron beam experiments. The systematic uncertainties associated with this method to evaluate Q' are discussed in detail. For recoil energies between 20 and 100 keV, the resulting heat quenching factor is Q' = 0.91+-0.03+-0.04, where the two errors are the contributions from the Q and Q/Q' measurements, respectively. The present compilation of Q values and evaluation of Q' represent one of the most precise determinations of the absolute energy scale for any detector used in direct searches for dark matter.

astro-ph↗
arXiv2006

MEMPHYS:A large scale water Cerenkov detector at Fréjus

A water Čerenkov detector project, of megaton scale, to be installed in the Fréjus underground site and dedicated to nucleon decay, neutrinos from supernovae, solar and atmospheric neutrinos, as well as neutrinos from a super-beam and/or a beta-beam coming from CERN, is presented and compared with competitor projects in Japan and in the USA. The performances of the European project are discussed, including the possibility to measure the mixing angle $θ_{13}$ and the CP-violating phase $δ$.

hep-ex↗
arXiv2005

Final results of the EDELWEISS-I dark matter search with cryogenic heat-and-ionization Ge detectors

The final results of the EDELWEISS-I dark matter search using cryogenic heat-and-ionization Ge detectors are presented. The final data sample corresponds to an increase by a factor five in exposure relative to the previously published results. A recoil energy threshold of 13 keV or better was achieved with three 320g detectors working simultaneously over four months of stable operation. Limits on the spin-independent cross-section for the scattering of a WIMP on a nucleon are derived from an accumulated fiducial exposure of 62 kg.d.

astro-ph↗
arXiv2005

Sensitivity of the EDELWEISS WIMP search to spin-dependent interactions

The EDELWEISS collaboration is searching for WIMP dark matter using natural Ge cryogenic detectors. The whole data set of the first phase of the experiment contains a fiducial exposure of 4.8 kg.day on Ge-73, the naturally present (7.8%), high-spin Ge isotope. The sensitivity of the experiment to the spin-dependent WIMP-nucleon interactions is evaluated using the model-independent framework proposed by Tovey et al.

astro-ph↗
arXiv2002

Improved Exclusion Limits from the EDELWEISS WIMP Search

The EDELWEISS experiment has improved its sensitivity for the direct search for WIMP dark matter. In the recoil energy range relevant for WIMP masses below 10 TeV/c2, no nuclear recoils were observed in the fiducial volume of a heat-and-ionization cryogenic Ge detector operated in the low-background environment of the Laboratoire Souterrain de Modane in the Frejus Tunnel, during an effective exposure of 7.4 kg.days. This result is combined with the previous EDELWEISS data to derive a limit on the cross-section for spin-independent interaction of WIMPs and nucleons as a function of WIMP mass, using standard nuclear physics and astrophysical assumptions. This limit excludes at more than 99.8%CL a WIMP candidate with a mass of 44 GeV/c2 and a cross-section of 5.4 x 10-6 pb, as reported by the DAMA collaboration. A first sample of supersymmetric models are also excluded at 90%CL.

astro-ph↗
arXiv2001

Study and suppression of anomalous fast events in inorganic scintillators for dark matter searches

The status of dark matter searches with inorganic scintillator detectors at Boulby mine is reviewed and the results of tests with a CsI(Tl) crystal are presented. The objectives of the latter experiment were to study anomalous fast events previously observed and to identify ways to remove this background. Clear indications were found that these events were due to surface contamination of crystals by alphas, probably from radon decay. A new array of unencapsulated NaI(Tl) crystals immersed either in liquid paraffin or pure nitrogen atmosphere is under construction at Boulby. Such an approach allows complete control of the surface of the crystals and the ability to remove any surface contamination. First data from the unencapsulated NaI(Tl) do not show the presence of anomalous fast events.

hep-ex↗
arXiv2001

First Results of the EDELWEISS WIMP Search using a 320 g Heat-and-Ionization Ge Detector

The EDELWEISS collaboration has performed a direct search for WIMP dark matter using a 320 g heat-and-ionization cryogenic Ge detector operated in a low-background environment in the Laboratoire Souterrain de Modane. No nuclear recoils are observed in the fiducial volume in the 30-200 keV energy range during an effective exposure of 4.53 kg.days. Limits for the cross-section for the spin-independent interaction of WIMPs and nucleons are set in the framework of the Minimal Supersymmetric Standard Model (MSSM). The central value of the signal reported by the experiment DAMA is excluded at 90% CL.

astro-ph↗
arXiv2001

Dark Matter Search in the EDELWEISS experiment

The EDELWEISS Dark Matter Search uses low-temperature Ge detectors with heat and ionisation read-out to identify nuclear recoils induced by elastic collisions with WIMPs from the galactic halo. Preliminary results obtained with 320g bolometers are described. After a few weeks of data taking, data accumulated with one of these detectors already allow to reach the upper part of the DAMA region. Prospects for the present run and the second stage of the experiment, EDELWEISS-II, using an innovative reversed cryostat allowing data taking with 100 detectors, are briefly described.

astro-ph↗
arXiv2001

The EDELWEISS Experiment : Status and Outlook

The EDELWEISS Dark Matter search uses low-temperature Ge detectors with heat and ionisation read- out to identify nuclear recoils induced by elastic collisions with WIMPs from the galactic halo. Results from the operation of 70 g and 320 g Ge detectors in the low-background environment of the Modane Underground Laboratory (LSM) are presented.

astro-ph↗
arXiv2001

Dark Matter Search in the Edelweiss Experiment

Preliminary results obtained with 320g bolometers with simultaneous ionization and heat measurements are described. After a few weeks of data taking, data accumulated with one of these detectors are beginning to exclude the upper part of the DAMA region. Prospects for the present run and the second stage of the experiment, EDELWEISS-II, using an innovative reversed cryostat allowing data taking with 100 detectors, are briefly described.

astro-ph↗