arXiv subjects

L. Tayebi

Publications and source records attributed to L. Tayebi.

3 recordsLinked to original sources

arXiv2026

Drug-delivery Ca-Mg silicate scaffolds encapsulated in PLGA

The aim of this work is to develop dual-functional scaffolds for bone tissue regeneration and local antibiotic delivery applications. In this respect, bioresorbable bredigite (Ca7MgSi4O16) porous scaffolds were fabricated by a foam replica method, loaded with vancomycin hydrochloride and encapsulated in poly lactic-co-glycolic acid (PLGA) coatings. Field emission scanning electron microscopy, Archimedes porosimetry and Fourier-transform infrared spectroscopy were used to characterize the structure of the scaffolds. The drug delivery kinetics and cytocompatibility of the prepared scaffolds were also studied in vitro. The bare sample exhibited a burst release of vancomycin and low biocompatibility with respect to dental pulp stem cells based on the MTT assay due to the fast bioresorption of bredigite. While keeping the desirable characteristics of pores for tissue engineering, the biodegradable PLGA coatings modified the drug release kinetics, buffered physiological pH and hence improved the cell viability of the vancomycin-loaded scaffolds considerably.

physics.bio-ph↗

arXiv2026

Controlled drug delivery from chitosan-coated heparin-loaded nanopores anodically grown on nitinol shape-memory alloy

Nitinol (NiTi shape-memory alloy) is an interesting candidate in various medical applications like dental, orthopedic, and cardiovascular devices, owing to its unique mechanical behaviors and proper biocompatibility. The aim of this work is the local controlled delivery of a cardiovascular drug, heparin, loaded onto nitinol treated by electrochemical anodizing and chitosan coating. In this regard, the structure, wettability, drug release kinetics, and cell cytocompatibility of the specimens were analyzed in vitro. The two-stage anodizing process successfully developed a regular nanoporous layer of Ni-Ti-O on nitinol, which considerably decreased the sessile water contact angle and induced hydrophilicity. The application of the chitosan coatings controlled the release of heparin mainly by a diffusional mechanism, where the drug release mechanisms were evaluated by the Higuchi, first-order, zero-order, and Korsmeyer-Pepass models. Human umbilical cord endothelial cells (HUVECs) viability assay also showed the non-cytotoxicity of the samples, so that the best performance was found for the chitosan-coated samples. It is concluded that the designed drug delivery systems are promising for cardiovascular, particularly stent applications.

physics.bio-ph↗

arXiv2025

Toward reducing the formation temperature of diopside via wet-chemical synthesis routes using chloride precursors

Reducing the formation temperature of single-phase multioxides is one of the classic challenges in ceramic processing, including wet-chemical synthesis routes. Toward pursuing this aim for diopside (MgCaSi2O6), the merit of different sol-gel and coprecipitation processes using the related chloride precursors followed by calcination was compared from the viewpoints of crystallinity and homogeneity. In accordance to the results, the use of the sol-gel techniques, directed with/without an alkaline catalyst, gave rise to the unfavorable creation of multiphase and low-crystallinity structures. Regarding the coprecipitation methods, the one-step addition of a precipitant agent is accompanied by an indirect low-temperature formation of nano-diopside, while a direct crystallization into this phase was explored in the dropwise condition, albeit with a lower crystallinity. Thus, by employing a suitable synthesis processing, it is feasible to take control of a wide range of nanoparticulate diopside-based structures achieved after a low-temperature calcination.

cond-mat.mtrl-sci↗